王西西;陈青;陈鸿军;朱鸿飞;李金祥;郭晓宇;

• 1:中国农业科学院北京畜牧兽医研究所
• 2:北京农学院农业部华北都市农业重点实验室
• 3:中国农业科学院上海兽医研究所
• 4:中国农业科学院

摘要(Abstract)：

非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)感染家猪和欧洲野猪后引起的烈性、出血性传染病,死亡率高达100%。病毒针对宿主天然免疫系统的逃逸是造成病毒持续感染的重要策略,在长期进化过程中,ASFV编码表达多种免疫逃逸蛋白以拮抗宿主免疫反应。已往研究对ASFV编码免疫逃逸蛋白进行了诸多报道,但是对其具体免疫逃逸分子机制研究仍不够深入。本文概括总结已有ASFV免疫逃逸蛋白在拮抗宿主天然免疫反应中的作用,以期为后续基因缺失疫苗研究和疫病防控提供相关借鉴。

关键词(KeyWords)： 非洲猪瘟病毒(ASFV);天然免疫;免疫逃逸蛋白;分子机制

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(项目号:2017YFD0502302),题目:烈性外来动物疫病防控技术研发~~

作者(Authors): 王西西;陈青;陈鸿军;朱鸿飞;李金祥;郭晓宇;

DOI: 10.13242/j.cnki.bingduxuebao.003456

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