张洪亮;金铭;赵越;王凤雪;马晶;温永俊;单虎;

• 1:内蒙古农业大学兽医学院农业部动物疾病临床诊疗技术重点实验室
• 2:青岛农业大学动物医学院山东省预防兽医学重点实验室

摘要(Abstract)：

非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种动物烈性传染病,发病率和死亡率高,是世界动物卫生组织(OIE)规定的强制报告疫病,我国将其列为一类动物疫病。由于缺乏临床可用的疫苗等预防手段,该病在非洲、东欧、北高加索、俄罗斯等范围内蔓延,并于2018年8月传入我国,对我国养猪业造成了重大经济损失。本文总结了ASFV免疫学和疫苗研究的现状,阐述了其病毒结构与蛋白功能、感染与免疫机制,分别介绍了ASFV灭活疫苗、减毒活疫苗、基因工程疫苗的研究进展,以期对非洲猪瘟疫苗的开发起到借鉴作用。

关键词(KeyWords)： 非洲猪瘟(ASF);非洲猪瘟病毒(ASFV);免疫学;疫苗

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(项目号:2016YFD0500707-7),题目:猪繁殖障碍性疾病鉴别诊断技术研究;; 内蒙古农业大学高层次人才引进项目(项目号:NDGCC2016-22);; 山东省现代农业产业技术体系生猪创新团队首席兼疫病控制岗位专家(项目号:SDAIT-08-01)~~

作者(Authors): 张洪亮;金铭;赵越;王凤雪;马晶;温永俊;单虎;

DOI: 10.13242/j.cnki.bingduxuebao.003557

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