2018~2020年广西边境地区手足口病流行特征及病原学分析Epidemiological Characteristics and Etiological Analyses of Hand,Foot and Mouth Disease in the Guangxi Border Area of China from 2018 to 2020
冀天娇;居昱;程文隽;陈敏玫;张勇;肖金波;张珂艺;刘宏图;许文波;
摘要(Abstract):
手足口病(Hand,foot and mouth disease,HFMD)是一种由肠道病毒引起的儿童常见传染病,近年来在亚太地区尤其是东南亚地区发生了多起HFMD的大暴发,而我国广西壮族自治区与越南接壤,往来密切。为了解其边境地区HFMD的流行概况和病原学构成,比较该地区病原优势基因型与相邻地区的变异与进化关系。本研究选取与越南接壤的百色、崇左、防城港作为研究对象,收集其2018-2020年HFMD疫情资料进行流行病学分析,并随机采集这三个地市的375份手足口病患儿的临床标本进行荧光定量PCR鉴定,对阳性毒株进行VP1编码区基因扩增及测定,获得的序列与GenBank上下载的各基因型/亚型的代表序列构建系统发生树。结果显示2018-2020年,广西边境地区的报告发病数、重症数、重症比例(重症/发病)和重症率均呈下降趋势,5岁以下儿童为主要发病人群,除2020年以外,其发病流行曲线呈典型的双峰分布。病原谱分析显示,整体上以其他EV为优势循环血清型,且CVA6、CVA16、CVA10和EVA71为该地区的优势病原。同时,2018-2020年期间广西边境流行的EVA71、CVA16、CVA6和CVA10的优势基因亚型分别为C4a、B1b、D3a和C2,且与东南亚临近国家同基因型的流行株具有较近的亲缘关系,提示病毒共同循环进化。而边境地区环境复杂、人员往来密切,因此加强边境地区手足口病的监测及预警系统的建设是西南边境地区手足口病防控的关键。
关键词(KeyWords): 手足口病;边境地区;流行特征;病原学特点
基金项目(Foundation): “十三五”科技重大专项(项目号:2018ZX10101002-004-006),题目:“一带一路”重要传染病流行规律和预警应对技术研究-东南亚地区手足口防控技术推广应用;“十三五”科技重大专项(项目号:2018ZX10201002-003-003),题目:手足口病流行特征及变异变迁规律的研究~~
作者(Authors): 冀天娇;居昱;程文隽;陈敏玫;张勇;肖金波;张珂艺;刘宏图;许文波;
DOI: 10.13242/j.cnki.bingduxuebao.004109
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