姜子玮;李晨辉;赵颖;付温爽;赵铁军;金志刚;

• 1:浙江师范大学化学与生命科学学院

摘要(Abstract)：

新型冠状病毒(Severe acute respiratory syndromes coronavirus 2,SARS-CoV-2)感染引发的新型冠状病毒肺炎(Corona Virus Disease 19,COVID-19)目前正在全球范围内对公众健康和安全造成重大威胁。冠状病毒的核衣壳(Nucleocapsid,N)蛋白主要作为病毒关键结构蛋白,负责与病毒基因组RNA结合组装成核衣壳,并进一步与膜(Membrane,M)蛋白结合组装成病毒体(Virion)。此外,N蛋白兼具调节蛋白功能,在抑制宿主天然免疫反应以及通过结合复制-转录复合体(Replication transcription complex,RTC)促进病毒转录和复制等过程中也发挥了重要作用。最近一些研究相继揭示了SARS-CoV-2 N蛋白具有与RNA或其他蛋白发生液-液相分离(Liquid-liquid phase separation,LLPS)的能力,并且N蛋白的相分离正逐渐被证实在其发挥结构蛋白和调节蛋白功能的过程中均具有重要作用。本文主要就SARS-CoV-2 N蛋白相分离的最新研究成果进行综述,并就N蛋白相分离作为治疗COVID-19的潜在药物靶点加以讨论。

关键词(KeyWords)： 新型冠状病毒(SARS-CoV-2);核衣壳蛋白;病毒复制;药物靶点;相分离

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（项目号：31970173），题目：Hippo-YAP信号通路在人类T细胞白血病1型病毒致癌中的作用及其分子机制研究;国家自然科学基金（项目号：31970755），题目：Hedgehog信号通路与应激颗粒的交互作用及其功能研究;; 浙江省自然科学基金（项目号：LY21C010001），题目：TGF-beta信号通路促进人类T细胞白血病1型病毒侵染的作用及其机制研究;浙江省自然科学基金（项目号：LY21C120001），题目：Hedgehog信号通路蛋白Rusc2对神经模式形成的调控;; 金华市科技局重点项目（项目号：2021-3-146），题目：靶向新型冠状病毒SARS-CoV-2 N蛋白的抗病毒药物研发及应用评价~~

作者(Authors): 姜子玮;李晨辉;赵颖;付温爽;赵铁军;金志刚;

DOI: 10.13242/j.cnki.bingduxuebao.004086

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