2014～2015年重庆市手足口病的流行病学及病原学特征The Epidemiology and Etiology Characteristics of Hand-foot-mouth Disease in Chongqing,China,2014～2015
顾新蕊,赵华,冀天娇,李勤,凌华,祝双利,张勇,杨倩,宋洋,黄为,许文波
摘要(Abstract)：
通过对2014~2015年重庆市手足口病(Hand-foot-mouth disease,HFMD)的流行病学、肠道病毒(Enterovirus,EV)病原构成和肠道病毒71型(Enterovirus A71,EV-A71)VP1区编码基因分析,为制定重庆市HFMD防控策略提供科学依据。2014~2015年全市报告HFMD共100176例,其中重症284例,死亡37例;全市39个区县(自治县)均有病例报告,且主城区报告发病率(298.83/10万)显著高于郊区(103.37/10万),5岁及以下的儿童占报告发病数95.64%,3岁及以下占83.21%,每年的4~7月为发病高峰期,每年的10~11月为发病小高峰期。重症和死亡病例在3岁和5岁及以下的年龄组中分别占86.97%、94.59%和96.83%、100%。其中重症病例主要集中在万州区、梁平县、涪陵区3个区县中,占全部重症病例的74.65%;死亡病例分布广泛,散在17个区县内。7503份HFMD临床标本的EV核酸检测结果,EV-A71、CV-A16、非EV-A71/CV-A16其他EV分别占23.54%、33.21%、43.25%;非EV-A71/CV-A16的其他EV成为导致重庆市HFMD的优势病原,但重症和死亡病例仍以EV-A71为绝对优势病原。对55株2014年和2015年重庆EV-A71代表毒株VP1编码序列测定和分析,提示54株均属于C4a,1株属于B5。本研究为重庆市制订HFMD防控策略,降低EV-A71引起的重症和死亡提供了重要的流行病学和病原学基础资料。
关键词(KeyWords)： 手足口病;重庆;重症;肠道病毒71型;流行病学;病原学
基金项目(Foundation): 重庆市医学科研计划项目(项目号:20142112),题目:重庆市手足口病死亡病例的病原学特征及病毒基因变异研究
作者(Author): 顾新蕊,赵华,冀天娇,李勤,凌华,祝双利,张勇,杨倩,宋洋,黄为,许文波
DOI: 10.13242/j.cnki.bingduxuebao.003066
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