朱紫祥,魏建超,史子学,吴开宝,马志永

• 1:中国农业科学院上海兽医研究所兽医公共卫生学实验室
• 2:南京农业大学动物医学院

摘要(Abstract)：

ISG15(Interferon stimulated gene 15,ISG15)蛋白是由干扰素诱导产生的一种泛素样蛋白分子,分子量大小约为15kD。ISG15同泛素分子相类似可以被共价结合于其他蛋白分子上,这种现象称为ISG化(ISGylation)现象。ISG化系统包括ISG15、UBE1L、UBCH8和HERC5四类蛋白分子,协同完成ISG化过程。ISG15及ISG化系统在抗病毒反应中具有重要作用。近几年对于ISG15的抗病毒作用和机制的研究已经有了很大的突破,ISG15的抗病毒作用也越来越受到人们重视,了解清楚ISG15抗病毒机制对于研制新的抗病毒药物及提出新的抗病毒策略具有重要意义。本文对ISG15在不同种病毒中的抗病毒机制研究进展进行了简要综述。

关键词(KeyWords)： ISG15;ISG化;抗病毒作用

Abstract:

Keywords:

基金项目(Foundation): 转基因生物新品种培育科技重大专项(2009ZX08010-022B);; 上海市基础研究重点项目(10JC1417300)

作者(Author): 朱紫祥,魏建超,史子学,吴开宝,马志永

DOI: 10.13242/j.cnki.bingduxuebao.002246

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