黎俊宏,嵇红,樊欢,李琼,王凤鸣,姚萍,单军

• 1:常州市疾病预防控制中心检测检验中心
• 2:江苏省疾病预防控制中心

摘要(Abstract)：

分析江苏省2015年柯萨奇病毒A组16型(CA16)分离株VP1基因特征。对江苏省2015年分离得到的20株CA16毒株进行VP1区基因扩增和扩增产物测序,并应用Mega 6.0和DNA Star软件对其构建基因进化树并分析核苷酸和氨基酸同源性。20株CA16分离株VP1核苷酸和氨基酸同源性分别为88.2%~100.0%和98.0%~100.0%;与A型国际原型株G10核苷酸和氨基酸同源性分别为75.3%~77.4%和90.6%~92.3%;与B1型代表株核苷酸和氨基酸同源性分别为88.3%~98.4%和96.3%~100.0%;与B2型代表株核苷酸和氨基酸同源性分别为88.4%~90.8%和96.6%~100.0%。20株CA16分离株基因亚型均为B1型,其中19株为B1b型,1株为B1a型,并有1个B1b传播链。江苏省2015年CA16分离株属于B1基因亚型,存在B1a和B1b两个进化分支共同进化和循环,其中以B1b为绝对优势流行株。

关键词(KeyWords)： 手足口病;柯萨奇病毒A组16型;VP1;B1

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年基金(项目号:81402732),题目:重症手足口病后遗症队列随访及其病原演变的特征性研究

作者(Author): 黎俊宏,嵇红,樊欢,李琼,王凤鸣,姚萍,单军

DOI: 10.13242/j.cnki.bingduxuebao.003063

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