潘力;罗瑞;王涛;罗玉子;孙元;仇华吉;

• 1:中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室

摘要(Abstract)：

非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种致死率可高达100%的猪烈性传染病。ASF的传播方式复杂多样,目前无商品化疫苗可用,仅能依靠检疫结合扑杀进行防控,严重威胁全球养猪及相关行业的健康发展。阻碍ASF疫苗研发的主要因素是ASFV的基因型众多、结构复杂,以及对ASFV致病和免疫逃逸机制的认识不足。本文从基因组学、转录组学、蛋白质组学和代谢组学等层面多角度综述ASFV的生物学特性及其致病和免疫逃逸机制,以期揭开ASF这个"杀手"的神秘面纱,为ASFV的致病机制研究和ASF的防控提供参考。

关键词(KeyWords)： 非洲猪瘟病毒;基因组学;转录组学;蛋白质组学;代谢组学

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（项目号：U20A2060），题目：辽宁省非洲猪瘟流行关键风险因素识别、病毒演化与毒力变化的分子机制;国家自然科学基金项目（项目号：32072854），题目：非洲猪瘟病毒毒力相关新基因的鉴定及其调控病毒毒力的机制~~

作者(Authors): 潘力;罗瑞;王涛;罗玉子;孙元;仇华吉;

DOI: 10.13242/j.cnki.bingduxuebao.004055

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