郝好杰;余宝成;胡章立;袁建辉;关武祥;

• 1:韩山师范学院
• 2:中国科学院武汉病毒研究所
• 3:深圳大学生命与海洋科学学院
• 4:深圳市南山区疾病预防控制中心

摘要(Abstract)：

早在60多年前科学家已经发现RNA化学修饰的存在，但直到近年来关于RNA修饰功能的研究才得到广泛关注及蓬勃发展，其中病毒RNA修饰的功能成为了病毒学研究领域新的热点。目前已有150多种RNA修饰被发现，这些修饰在调控RNA结构、剪接、核运输、翻译、稳定性等多种生物过程中发挥重要作用。目前病毒RNA修饰中最受关注的7种化学修饰包括N6-甲基腺苷（m6A）、5-甲基胞苷（m5C）、N1-甲基腺苷（m1A）、N7-甲基鸟苷（m7G）、N4-乙酰胞苷（ac4C）、假尿苷（Ψ）和核糖甲基化（Nm）。本文介绍了细胞中的修饰系统，讨论了当前各种修饰的检测方法并对这些修饰在病毒复制中的功能进行了归纳总结。此外，我们提出了病毒RNA修饰未来可能的一些研究方向。

关键词(KeyWords)： RNA化学修饰;病毒感染;甲基化修饰;乙酰化修饰;假尿嘧啶

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（项目号：32000114）,题目：N4-acetylcytidine调控肠病毒71型复制的分子机制~~

作者(Authors): 郝好杰;余宝成;胡章立;袁建辉;关武祥;

DOI: 10.13242/j.cnki.bingduxuebao.220182

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