张雨薇,程安春,汪铭书

• 1:四川农业大学动物医学院禽病防治研究中心
• 2:四川农业大学预防兽医研究所
• 3:四川农业大学动物疫病与人类健康四川省重点实验室

摘要(Abstract)：

疱疹病毒VP16蛋白是疱疹病毒重要的皮层蛋白,参与病毒立即早期基因转录的激活、病毒在宿主细胞内的装配与释放等过程,与许多病毒蛋白和宿主蛋白都存在蛋白相互作用,且部分疱疹病毒VP16具有去泛素活性以及帮助病毒抵御宿主免疫的功能。本文将以疱疹病毒VP16蛋白的结构特点为基础来阐述VP16的功能及其复杂的相互作用,为深入研究疱疹病毒的成熟过程以及VP16涉及的相互作用提供参考。

关键词(KeyWords)： 疱疹病毒;VP16蛋白;转录激活域;病毒装配;蛋白相互作用

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划(项目号:2015BAD12B05);; 国家现代农业(水禽)产业技术体系专项(项目号:CARS-43-8),题目:免疫抑制病与新疫苗;; 国家自然科学基金(项目号:31272545),题目:鸭瘟病毒皮层蛋白UL14在病毒成熟和免疫逃避中的作用机制;; 四川省创新团队重点项目(项目号:2014NZ0030/2016JPT0004),题目:肉鸭现代化产业链关键技术研究集成与示范项目

作者(Author): 张雨薇,程安春,汪铭书

DOI: 10.13242/j.cnki.bingduxuebao.003082

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