丁国永,王志玉,高璐,姜宝法

• 1:泰山医学院公共卫生学院
• 2:山东大学公共卫生学院

摘要(Abstract)：

埃博拉病毒可引起人类高致命性流行性出血热暴发,至今没有预防和治疗的疫苗和药物。作为埃博拉病毒包膜唯一的表面蛋白,包膜糖蛋白是一种多功能蛋白质,在病毒的吸附和穿入宿主细胞、致病性、下调宿主细胞表面蛋白质表达和增加病毒装配和出芽过程中起着至关重要的作用;同时包膜糖蛋白是保护性免疫的主要目标,是诱导产生中和抗体的最理想抗原。本文就近五年埃博拉病毒包膜糖蛋白的基因结构、致病机制和免疫原性方面的研究进展做简要回顾。

关键词(KeyWords)： 埃博拉病毒;包膜糖蛋白;致病机制;免疫原性

Abstract:

Keywords:

基金项目(Foundation): 国家重大科学研究计划(编号2012CB955502)

作者(Author): 丁国永,王志玉,高璐,姜宝法

DOI: 10.13242/j.cnki.bingduxuebao.002370

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