于永忠;吴志军;朱战波;潘求真;崔玉东;

• 1:黑龙江八一农垦大学生命科学技术学院细胞生物学实验室
• 2:黑龙江八一农垦大学动物科学学院预防兽医学实验室

摘要(Abstract)：

羊传染性脓疱皮炎(Contagious ecthyma)俗称羊口疮(Orf)是由羊口疮病毒(Orf virus,ORFV)引起的一种人畜共患传染病。ORFV是痘病毒科副痘病毒属的代表性成员之一,具有鲜明而独特的种属特征。在进化过程中,病毒捕获一系列免疫调节/致病性相关基因,通过各种表达产物协同性地限制宿主的免疫清除效应,以庇护种群的增殖和病毒粒子成熟。本文综述了ORFV的分子特征,着重分析了病毒主动干预宿主免疫应答、设计免疫逃逸的分子机制。明确病毒的免疫调节/致病性元件及其效应途径,有利于加深对ORFV生物学特性的理解,同时有利于针对Orf建立有效的防制。

关键词(KeyWords)： 羊口疮病毒;分子特征;免疫调节剂;免疫逃逸

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(31172353);; 国家转基因生物新品种培育科技重大专项(2009ZX08010-020B)

作者(Authors): 于永忠;吴志军;朱战波;潘求真;崔玉东;

DOI: 10.13242/j.cnki.bingduxuebao.002277

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