王欢;丁铲;廖瑛;

• 1:中国农业科学院上海兽医研究所

摘要(Abstract)：

冠状病毒家族成员众多,主要感染哺乳动物和禽鸟类,给人类和动物的健康带来了极大危害。病毒对细胞表面受体的结合和内吞方式,决定病毒的宿主范围、组织嗜性和发病机理;此外,研究病毒的入胞途径不仅有助于我们认识病毒的生活周期,还对病毒性感染的预防和治疗具有重要意义。本文总结归纳了近十年来冠状病毒入胞途径的研究进展:多数冠状病毒可通过网格蛋白依赖型内吞、小窝蛋白依赖型内吞、巨胞饮以及网格蛋白/小窝蛋白非依赖型内吞途径进入细胞,到达早期内体、晚期内体或溶酶体等处发生膜融合,释放病毒基因组进入细胞质。病毒的内吞途径可作为广谱抗病毒药物设计的靶点。

关键词(KeyWords)： 冠状病毒;受体;内吞作用;抗病毒药物

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(项目号：31772724),题目：应激颗粒作为抗病毒天然免疫信号枢纽的研究;; 中国农业科学院上海兽医研究所中央级公益性科研院所基本科研业务费专项资金项目(项目号：2017JB05),题目：传染性支气管炎病毒的入胞方式和脱壳位点的研究~~

作者(Authors): 王欢;丁铲;廖瑛;

DOI: 10.13242/j.cnki.bingduxuebao.003586

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