孙西魁,刘兴龙,冯立强

• 1:华侨大学生物医学学院
• 2:呼吸疾病国家重点实验室中国科学院广州生物医药与健康研究院

摘要(Abstract)：

人腺病毒感染常导致急性呼吸道疾病、结膜炎、肠胃炎甚至重症肺炎。目前,临床上尚无特效抗腺病毒药物。建立可支持腺病毒感染/致病的动物模型对于腺病毒致病机制研究及制定抗腺病毒策略至关重要。目前某些腺病毒的感染受体尚未阐明,以及临床上常见的B种腺病毒无法感染啮齿类动物,影响了对此类腺病毒感染的研究。此外,人腺病毒具有宿主范围的种属特异性,在感染的其它种属的动物细胞中由于宿主范围限制因子的存在,而不能有效复制、增殖,严重阻碍了对腺病毒体内致病机制的研究。本文综述了近年来人腺病毒感染受体、宿主范围限制因子以及感染模型等方面的进展,以期为新型腺病毒感染/致病动物模型的研究提供参考。

关键词(KeyWords)： 人腺病毒(HAdV);受体;宿主范围的种属特异性;动物模型

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(项目号:31470892),题目:新型流感病毒载体艾滋病疫苗诱导新膜免疫反应的作用及机制研究;; 广州市科技计划(项目号:201504010032),题目:人腺病毒和流感病毒动物模型的建立及应用研究

作者(Author): 孙西魁,刘兴龙,冯立强

DOI: 10.13242/j.cnki.bingduxuebao.003081

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