陆小凡,李莉,夏欢,吴昊,粟斌,张彤

• 1:艾滋病研究北京市重点实验室首都医科大学附属北京佑安医院
• 2:感染中心首都医科大学附属北京佑安医院

摘要(Abstract)：

干细胞样记忆型T细胞(Stem memory T cells,Tscm)是最早期分化的、存活时间最长的一类记忆型T细胞。这类细胞具有自我更新及多能分化等干细胞特性,其在抗肿瘤中具有重要的作用,在HIV-1感染中的作用也开始成为研究热点。本文对Tscm细胞的特点、CD4+Tscm细胞在HIV-1病毒储藏库中的重要性及CD8+Tscm细胞抗病毒作用的最新研究进行介绍。了解并充分利用Tscm细胞的特性及其在HIV-1感染中的作用,将有助于开发以Tscm为靶点的HIV-1疫苗及免疫治疗新方法,为HIV-1的防控及功能性治愈提供新的策略。

关键词(KeyWords)： 干细胞样记忆型T细胞;病毒储藏库;抗病毒作用;人获得性免疫缺陷病毒(HIV-1)

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(项目号:81501732),题目:干细胞样记忆型T细胞在HIV-1患者免疫重建中的作用;; 北京市医院管理局临床医学发展专项经费(项目号:ZY201401),题目:“扬帆”计划;; 艾滋病研究北京市重点实验室(BZ0089)

作者(Author): 陆小凡,李莉,夏欢,吴昊,粟斌,张彤

DOI: 10.13242/j.cnki.bingduxuebao.003079

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