2024 06 v.40 1453-1461
MOV10在细胞生物学与抗病毒功能中的研究进展
基金项目(Foundation):
吉林省自然科学基金（项目号：20230101172JC）,题目：天然免疫限制因子MOV10限制狂犬病病毒复制的分子机制研究~~
邮箱(Email):
zhanghaili@jlu.edu.cn;
DOI:
10.13242/j.cnki.bingduxuebao.004598
中文作者单位:
吉林大学动物医学学院人畜共患传染病重症诊治全国重点实验室;
摘要(Abstract):
莫洛尼白血病病毒10(Moloney leukemia virus 10, MOV10)是一种广泛存在于生物中的RNA解旋酶，是DICER-AGO介导的miRNA通路中无膜细胞器P-Bodies的重要组成蛋白，在肿瘤侵袭、胚胎发育、转座子逆转录等方面发挥作用。近年来又发现，MOV10可作为天然免疫限制因子，在病毒感染过程中，通过自身的结构特征或者参与到干扰素通路等方式来调控病毒的复制。本文主要阐述了MOV10的发现、结构特征、生物学功能，重点综述了MOV10在抗病毒功能方面的相关作用与机制，以期为MOV10抗病毒机制的阐明及今后的研究方向提供一定的参考。
关键词(KeyWords):
MOV10;miRNA通路;抗病毒机制
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参考文献
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004598
中图分类号:R373
引用信息:
[1]柳永赛,宋雨濛,王化磊等.MOV10在细胞生物学与抗病毒功能中的研究进展[J].病毒学报,2024,40(06):1453-1461.DOI:10.13242/j.cnki.bingduxuebao.004598.
基金信息:
吉林省自然科学基金（项目号：20230101172JC）,题目：天然免疫限制因子MOV10限制狂犬病病毒复制的分子机制研究~~
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