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埃博拉病毒(Ebola virus)是丝状病毒科的一员,可导致埃博拉出血热,致死率达25%~90%不等。2014年暴发的埃博拉疫情席卷了西非各地,极高的致死率引起了全世界的恐慌。鉴于埃博拉病毒严重威胁人类公共健康,科学研究毫无懈怠,多种疫苗如rVSV-ZEBOV和ChAd3-ZEBOV等已经进入临床试验阶段,多种药物如TKMEbola和ZMapp等已用于埃博拉患者的紧急治疗。本文总结了近期埃博拉疫苗和药物的最新研究进展。
Abstract:The Ebola virus belongs to the Filovirus family,which causes Ebola hemorrhagic fever(mortality,25%-90%).An outbreak of infection by the Ebola virus is sweeping across West Africa,leading to high mortality and worldwide panic.The Ebola virus has caused a serious threat to public health,so intensive scientific studies have been carried out.Several vaccines(e.g.,rVSV-ZEBOV,ChAd3-ZEBOV)have been put into clinical trials and antiviral drugs(e.g.,TKM-Ebola,ZMAPP)have been administered in the emergency setting to patients infected by the Ebola virus.Here,recent advances in vaccines and drugs against the Ebola virus are reviewed.
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基本信息:
DOI:10.13242/j.cnki.bingduxuebao.002698
中图分类号:R392
引用信息:
[1]朱祥,尧晨光,魏艳红,等.埃博拉疫苗和药物研究进展[J].病毒学报,2015,31(03):287-292.DOI:10.13242/j.cnki.bingduxuebao.002698.
基金信息:
湖北工业大学启动基金(Nr.337.193);; “十二五”国家科技重大专项项目基金(2012ZX10004503-008)
2015-05-29
2015-05-29
2015-05-29