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2017, 05, v.33 774-779
溶瘤病毒联合小分子抑制剂应用于肿瘤治疗的研究进展
基金项目(Foundation):
邮箱(Email):
DOI: 10.13242/j.cnki.bingduxuebao.003206
发布时间: 2017-07-26
出版时间: 2017-07-26
网络发布时间: 2017-07-26
摘要:

溶瘤病毒因具有选择性杀伤肿瘤细胞的特性,已成为目前较有前景的肿瘤治疗类药物。溶瘤病毒疗法的安全性和有效性在临床中已得到证实,但由于恶性肿瘤高度的异质性和复杂性使得溶瘤病毒单药治疗肿瘤的效果受限,因此溶瘤病毒联合其他肿瘤治疗药物一起协同治疗肿瘤将是未来肿瘤治疗的重要发展方向之一,有望为肿瘤的治疗带来新的突破。新近研究表明,不同的小分子抑制剂可通过多种机制控制肿瘤生长,其在体外协同溶瘤病毒能达到更优的肿瘤治疗效果。本文就目前溶瘤病毒联合小分子抑制剂治疗肿瘤的研究进展进行综述。

Abstract:

Due to thier characteristic feature of selectively killing cancer cells,oncolytic virus has been considered one of the promising agents for cancer treatment.The safety and efficacy of oncolytic virotherapy has been proved in multiple clinical trials.But so far oncolytic virus has been demonstrated limited efficacy as single therapeutic agent in the clinical setting of malignant cancer with high heterogeneity and complexity.Combination treatment of oncolytic virus and other anti-cancer drugs could be an important research direction in the future,which is expected to bring new therapeutic options for cancer patients.Recent research has demonstrated that small molecule inhibitors can target cancer cells by different mechanisms.Combination of small molecule inhibitors with oncolytic virus may result in synergistic antitumor effects both in vivo and in vitro.We summarize current progress of combination therapy using oncolytic virus and small molecule inhibitors for cancer treatment.

参考文献

[1]Ledford H.Cancer-fighting viruses win approval[J].Nature,2015,526(7575):622-623.

[2]Fukuhara H,Ino Y,Todo T.Oncolytic virus therapy:A new era of cancer treatment at dawn[J].Cancer Sci,2016,107(10):1373-1379.

[3]Russell S J,Peng K W,Bell J C.Oncolytic virotherapy[J].Nat Biotechnol,2012,30(7):658-670.

[4]Ilkow C S,Swift S L,Bell J C,Diallo J S.From scourge to cure:tumour-selective viral pathogenesis as a new strategy against cancer[J].PLoS Pathog,2014,10(1):e1003836.

[5]Huang J H,Zhang S N,Choi K J,Choi I K,Kim J H,Lee M,Kim H,Yun C O.Therapeutic and tumor-specific immunity induced by combination of dendritic cells and oncolytic adenovirus expressing IL-12and 4-1BBL[J].Mol Ther,2009,18(2):264-274.

[6]Beug S T,Tang V A,Lacasse E C,Cheung H H,Beauregard C E,Brun J,Nuyens J P,Earl N,St-Jean M,Holbrook J.Smac mimetics and innate immune stimuli synergize to promote tumor death[J].Nat Biotechnol,2014,32(2):182-190.

[7]Cassady K A,Haworth K B,Jackson J,Markert J M,Cripe T P.To infection and beyond:the multi-pronged anti-cancer mechanisms of oncolytic viruses[J].Viruses,2016,8(2):43.

[8]Patel M R,Kratzke R A.Oncolytic virus therapy for cancer:the first wave of translational clinical trials[J].Translational Research,2013,161(4):355.

[9]Ikeda K,Wakimoto H,Ichikawa T,Jhung S,Hochberg F H,Louis D N,Chiocca E A.Complement depletion facilitates the infection of multiple brain tumors by an intravascular,replication-conditional herpes simplex virus mutant[J].J Virol,2000,74(10):4765-4775.

[10]Xu Z,Tian J,Smith J S,Byrnes A P.Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors,natural antibodies,and complement[J].J Virol,2008,82(23):11705-11713.

[11]Marchini A,Scott E M,Rommelaere J.Overcoming barriers in oncolytic virotherapy with HDAC inhibitors and immune checkpoint blockade[J].Viruses,2016,8(1):9.

[12]Aurelian L.Oncolytic viruses as immunotherapy:progress and remaining challenges[J].Onco Targets Ther,2016,9:2627.

[13]Allazikani B,Banerji U,Workman P.Combinatorial drug therapy for cancer in the post-genomic era[J].Nat Biotechnol,2012,30(7):679-692.

[14]Lavanya V,Mohamed A A A,Ahmed N,Rishi A K,Jamal S.Small molecule inhibitors as emerging cancer therapeutics[J].2014,1(3):39-46.

[15]Ottolinoperry K,Diallo J S,Lichty B D,Bell J C,Mccart J A.Intelligent design:combination therapy with oncolytic viruses[J].Mol Ther,2010,18(18):251-263.

[16]Arora A,Scholar E M.Role of tyrosine kinase inhibitors in cancer therapy[J].J Pharmacol Exp Ther,2005,315(315):971-979.

[17]Laurent A,Rose Y,Morris S,Jaquith J.Protein kinase inhibitors[J].2017.

[18]Bex A.Adjuvant sunitinib in renal-cell carcinoma[J].New Engl J Med,2017,376(9):893.

[19]Hou W,Chen H,Rojas J,Sampath P,Thorne S H.Oncolytic vaccinia virus demonstrates antiangiogenic effects mediated by targeting of VEGF[J].Int J Cancer,2014,135(5):1238-1246.

[20]Jha B K,Dong B,Nguyen C T,Polyakova I,Silverman R H.Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy[J].Mol Ther,2013,21(9):1749.

[21]News.Phase 2Study of JX-594for liver cancer[J].Jaapa.

[22]Yoo S Y,Badrinath N,Woo H Y,Heo J.Oncolytic Virus-based immunotherapies for hepatocellular carcinoma[J].Mediators Inflamm,2017,2017:12.

[23]Fu X,Tao L,Rivera A,Zhang X.Rapamycin enhances the activity of oncolytic herpes simplex virus against tumor cells that are resistant to virus replication[J].Int J Cancer,2011,129(6):1503-1510.

[24]Alain T,Lun X,Martineau Y,Sean P,Pulendran B,Petroulakis E,Zemp F J,Lemay C G,Roy D,Bell J C.Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production[J].Proc Natl Acad Sci U S A,2010,107(4):1576-1581.

[25]Tu Y,Chen C,Pan J,Xu J,Zhou Z G,Wang C Y.The Ubiquitin proteasome pathway(UPP)in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis[J].Int J Clin Exp Pathol,2012,5(8):726-738.

[26]Carew J S,Espitia C M,Zhao W,Kelly K R,Coffey M,Freeman J W,Nawrocki S T.Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer[J/OL].Cell Death Dis,2013,4(7):e728.

[27]Diallo J,Betton B,N,Peant B,Lessard L,Le-Page C,Bertrand R,Mes-Masson A,Saad F.Enhanced killing of androgen-independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors[J].Br J Cancer,2008,99(10):1613.

[28]Yarde D N,Nace R A,Russell S J.Oncolytic vesicular stomatitis virus and bortezomib are antagonistic against myeloma cells in vitro but have additive anti-myeloma activity in vivo[J].Exp Hematol,2013,41(12):1038-1049.

[29]Boozari B,Mundt B,Woller N,Strüver N,Gürlevik E,Schache P,Kloos A,Knocke S,Manns M P,Wirth T C.Antitumoural immunity by virus-mediated immunogenic apoptosis inhibits metastatic growth of hepatocellular carcinoma[J].Gut,2010,59(10):1416.

[30]Forbes N E,Krishnan R,Diallo J S.Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses[J].Front Oncol,2014,4:191.

[31]Thorne S H,Negrin R S,Contag C H.Synergistic antitumor effects of immune cell-viral biotherapy[J].Science,2006,311(5768):1780.

[32]Liu C,Erlichman C,Mcdonald C J,Ingle J N,Zollman P,Iankov I,Russell S J,Galanis E.Heat shock protein inhibitors increase the efficacy of measles virotherapy[J].Gene Ther,2008,15(14):1024-1034.

[33]Magnani L,Eeckhoute J,Lupien M.Pioneer factors:Directing transcriptional regulators within the chromatin environment[J].Trends Genet,2011,27(11):465.

[34]Forbes N E,Abdelbary H,Lupien M,Bell J C,Diallo J S.Exploiting tumor epigenetics to improve oncolytic virotherapy[J].Front Genet,2013,4:184.

[35]Nguyên L A,Abdelbary H,Arguello M,Leveille S,Bell J C,Hiscott J.322Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis[J].Cytokine,2008,105(39):14981-14986.

[36]Liu T C,Branco P C,Rabkin S D,Martuza R L.Trichostatin A and oncolytic hsv combination therapy shows enhanced antitumoral and antiangiogenic effects[J].Mol Ther,2008,16(6):1041-1047.

[37]Alvarezbreckenridge C A,Yu J,Price R,Wei M,Wang Y,Nowicki M O,Ha Y P,Bergin S,Hwang C,Fernandez S A.The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon[J].J Virol,2012,86(8):4566-4577.

[38]Cedar H,Bergman Y.Linking DNA methylation and histone modification:patterns and paradigms[J].Nat Rev Genet,2009,10(5):295-304.

[39]Okemoto K,Kasai K,Wagner B,Haseley A,Meisen H,Bolyard C,Mo X,Wehr A,Lehman A,Fernandez S.DNA demethylating agents synergize with oncolytic HSV1against malignant gliomas[J].Clin Cancer Res,2013,19(21):5952-5959.

基本信息:

DOI:10.13242/j.cnki.bingduxuebao.003206

中图分类号:R730.5

引用信息:

[1]陈琴,黄承浩,夏宁邵.溶瘤病毒联合小分子抑制剂应用于肿瘤治疗的研究进展[J].病毒学报,2017,33(05):774-779.DOI:10.13242/j.cnki.bingduxuebao.003206.

发布时间:

2017-07-26

出版时间:

2017-07-26

网络发布时间:

2017-07-26

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