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诺如病毒(Norovirus,NoV)目前是流行病毒性胃肠炎最常见病原之一。该病原体流行株多变、致病剂量低、极易传播且缺乏理想的疫苗,致使全球范围内因NoV引起的胃肠炎频繁暴发,近年来其感染发病率呈明显增加的趋势。掌握NoV的结构特征及蛋白功能对预防NoV引起的流行性胃肠炎具有重要意义。本文对NoV的衣壳蛋白的功能及其基因组特征的研究现状做一综述。
Abstract:Norovirus(NoV)is one of the most predominant viral agents of acute gastroenteritis at present. With the diversity of variants,low disease-causing doses,easy transmissibility,and no approved vaccines,it is hard to manage NoV burden around the world. In recent years,the infections of NoV have increased popularity among human beings. Efforts to understand the characteristic of NoV and the function of the capsid protein are regarded as a promising approach to prevent the infection. This review aims to summarize the function of the capsid protein of NoV as well as its characteristic of the genome.
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基本信息:
DOI:10.13242/j.cnki.bingduxuebao.003891
中图分类号:R373.2
引用信息:
[1]廖颖茵,薛亮,高珺珊,等.诺如病毒分子结构特征及其衣壳蛋白功能研究进展[J].病毒学报,2021,37(02):459-464.DOI:10.13242/j.cnki.bingduxuebao.003891.
基金信息:
国家自然科学基金青年基金(项目号:31701717),题目:衣壳蛋白关键氨基酸突变对食源性诺如病毒GII.17型流行性的影响及分子机制研究; 广东省自然科学基金(项目号:2017A030313169),题目:诺如病毒衣壳蛋白在病毒样颗粒体外表达中的调控作用; 广东省科学院2019年建设国内一流研究机构专项-百名青年人才培养专项(项目号:2019GDASYL-0104008),题目:食源性诺如病毒衣壳蛋白特征性抗原表位的分子变异机制研究~~