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过去的几十年中，大多数病毒性新发传染病都由野生动物来源的病原体所引起，其中就包括冠状病毒。在所有公认的宿主中，蝙蝠（翼手目）被认为是冠状病毒的储存宿主，储蓄着大量古老且多样的冠状病毒。尽管啮齿目动物通常被视为传播病原体的另一关键类群，目前却很少有综述针对其所携带的冠状病毒进行介绍并评估潜在的威胁。为此，本文总结了近年来啮齿目冠状病毒流行情况的研究进展，探讨了两种人类冠状病毒的出现与啮齿目动物之间的联系，在分析了啮齿目独特的宿主习性以及相关冠状病毒的分子特征后，对该来源的冠状病毒的人兽共患病潜力进行了评估。
Abstract：In the past few decades, most emerging infectious diseases were caused by pathogens from wildlife, including coronaviruses. Among all recognized hosts, bats(Chiroptera) are considered as the natural reservoir for coronaviruses, as they harbored a large number of ancient and genetically diverse coronaviruses. Although rodents(Rodentia) are generally considered as remarkable Order for zoonotic transmission, little reviews have been conducted to introduce the rodent-associated coronaviruses and assess their potential threat. This review summarized the latest research on the prevalence of rodent-associated coronaviruses(RCoV) and discussed the clues between the emergence of two human coronaviruses and RCoVs. By analyzing the distinct host habits and the molecular characteristics of the RCoVs, the zoonosis potential of RCoVs were assessed.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004299
中图分类号:S852.65
引用信息:
[1]梁杰超,王嘉.啮齿目动物宿主——冠状病毒的另一个潘多拉魔盒？[J].病毒学报,2023,39(05):1474-1483.DOI:10.13242/j.cnki.bingduxuebao.004299.
基金信息:
广东省科技专项资金（项目号：2019ST042）;题目：基于大数据分析的病原诊断和防治;广东省科技专项资金（项目号：210804126870918）;题目：病毒性新发传染病的研究与防治~~