首都医科大学附属北京地坛医院肝病二科;北京大学地坛教学医院肝病二科;
本研究旨在探索原发性胆汁性胆管炎(Primary biliary cholangitis, PBC)患者经熊去氧胆酸(Ursodeoxycholic acid, UDCA)治疗对新冠病毒感染及临床结局的影响。符合PBC诊断标准的患者入组,按照患者是否接受UDCA治疗分为两组:经UDCA治疗组和未经UDCA治疗组。收集患者PBC诊断相关资料、治疗信息等临床资料,观察新冠病毒感染患者感染率、发病及预后指标。共收集1137例自身免疫性肝病患者,筛选出569例PBC患者,其中56例患者在随访期间丢失,513例患者完成了随访,包括女性402例,男性111例,平均年龄58.17±11.03岁。UDCA治疗组和非UDCA治疗组分别406例、107例。UDCA治疗组中治疗PBC的激素使用率(11.08%)显著高于非UDCA治疗组(2.80%)(χ~2=6.845, P=0.009)。总人群新冠病毒感染率为80.90%,感染者的年龄(57.08±10.84)显著低于未感染者(62.78±10.69)(t=4.691, P<0.001),未感染者UDCA的使用率(87.76%)显著高于感染患者(77.11%)(χ~2=5.444, P=0.020),并且UDCA治疗者的新冠病毒感染率(80.79%)显著低于非UDCA治疗者(88.78%)(χ~2=5.444, P=0.020),单因素和多因素Logistic回归分析显示,年龄(OR=1.053,P<0.001,95%CI(1.029-1.077))和UDCA的使用率(OR=2.218,P=0.022,95%CI (1.115-4.059))与新冠病毒感染率较低有关。在新冠病毒感染患者中,UDCA治疗组中女性新冠病毒感染者的比例高于男性(82.81%vs. 17.19%, P<0.001),UDCA治疗组新冠病毒感染恢复时间显著长于非UDCA治疗组(9.63±6.80 vs. 7.46±3.58, P=0.003)。无论是否经UDCA治疗,所有新冠病毒感染患者均好转。PBC患者UDCA的使用与新冠病毒感染的低发生率相关,接受UDCA治疗的患者感染后的恢复时间更长。
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基本信息:
DOI:10.13242/j.cnki.bingduxuebao.004644
中图分类号:R575.7;R511
引用信息:
[1]曹卫华,王诗雨,张子昱等.经UDCA治疗原发性胆汁性胆管炎患者的新冠病毒感染临床特征研究[J].病毒学报,2025,41(01):16-22.DOI:10.13242/j.cnki.bingduxuebao.004644.
基金信息:
国家重点研发计划项目(项目号:2022YFC2603500,2022YFC2603505),题目:高等级生物安全实验室个体防护装备关键技术研究与应用示范; 北京市医院管理局临床医学发展专项经费资助项目(项目号:XMLX 202127),题目:干扰素治疗获得功能性治愈的慢性乙型肝炎患者持续应答及复发相关因素的研究; 北京市医院管理中心消化内科学科协同发展中心(项目号:XXZ0302),题目:非酒精性脂肪肝组织学对终点时间的预测研究; 首都健康研发专项(项目号:2022-1-2172),题目:慢性乙型肝炎经治低病毒血症患者的优化治疗及临床结局研究; 北京市卫健委高层次公共卫生技术人才建设项目(项目号:学科带头人-03-26)~~