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铁死亡是一种铁依赖的，以脂质过氧化物积累为特征的程序性细胞死亡方式。近年来，铁死亡在多种病理生理过程中的调控作用逐渐被揭示。在病毒感染领域，多种病毒可通过诱导铁死亡来影响其感染进程，为深入理解病毒—宿主相互作用机制开辟了新的研究方向。本文基于最新研究进展，系统性地阐述了以下内容：（1）铁死亡的分子特征及其关键调控通路；（2）不同类型病毒感染诱导铁死亡的特异性调控机制。旨在深入解析病毒和铁死亡之间的调控关系，为开发靶向铁死亡通路的抗病毒治疗策略提供重要的理论参考。
Abstract：Ferroptosis is an iron-dependent form of programmed cell death characterized by the accumulation of lipid peroxides. In recent years, its regulatory roles in diverse pathophysiological processes have been increasingly recognized. In the context of viral infections, many viruses can induce ferroptosis to modulate their infection processes, thereby opening new avenues for understanding virus–host interactions. Based on the latest research advances, this review systematically addresses the following aspects:(1) the molecular features of ferroptosis and its key regulatory pathways, and(2) the virus type – specific mechanisms by which viral infections induce ferroptosis. This work aims to elucidate the regulatory interplay between viruses and ferroptosis and to provide theoretical insights for developing antiviral therapeutic strategies targeting ferroptosis pathways.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.250189
中图分类号:R511
引用信息:
[1]柴超杰,程治蓉,吴晓宇,等.铁死亡在病毒感染致病机制中的调控作用[J].病毒学报,2026,42(02):683-692.DOI:10.13242/j.cnki.bingduxuebao.250189.
基金信息:
陕西省重点研发计划项目（项目号：2025SF-YBXM-419）,题目：日本脑炎病毒在小鼠脑组织的时序性分布与小鼠发病特征行为的相关性研究~~
2025-06-18
2025
2025-09-09
2025-10-21
2025
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2025-10-22
2025-10-22
2025-10-22