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噬菌体能够裂解特定的细菌，在农业、畜牧业和医学中的病原体诊断和治疗中发挥作用。炭疽芽孢杆菌和蜡样芽孢杆菌是引发炭疽和食物中毒的病原菌，可对人体产生危害。本文就炭疽芽孢杆菌噬菌体和蜡样芽孢杆菌噬菌体的分离鉴定及其应用现状等方面进行简要综述，以期扩展人们对致病性芽孢杆菌噬菌体的了解。
Abstract：Phages can lyse specific bacteria and play a role in the diagnosis and treatment of pathogens in agriculture, animal husbandry and medicine. Bacillus anthracis and Bacillus cereus are pathogenic bacteria responsible for anthrax and food poisoning, respectively, posing significant risks to human health. This paper provides a brief review on the isolation, identification and current applications of Bacillus anthracis phages and Bacillus cereus phages, aiming to enhance understanding of phage targeting pathogenic spore-forming bacteria.
[1]张小妹，林建涵，阮士龙，等.控制细菌生物膜感染的可替代策略-噬菌体疗法[J].食品安全质量检测学报，2023,14(21):55-62. DOI:10. 19812/j. cnki. jfsq11-5956/ts. 2023. 2
[2] Fortier LC, Sekulovic O. Importance of prophages to evolution and virulence of bacterial pathogens[J].Virulence, 2013, 4(5):354-365. DOI:10. 4161/viru. 24498
[3] Dion MB, Oechslin F, Moineau S. Phage diversity,genomics and phylogeny[J]. Nat Rev Microbiol. 2020;18(3):125-138. DOI:10. 1038/s41579-019-0311-5
[4]程晓薇，田伟，李相安.噬菌体在细菌性疾病治疗中的研究进展[J].山东畜牧兽医，2023,44(09):83-86.DOI:10. 3969/j. issn. 1007-1733. 2023. 09. 028
[5]中国噬菌体研究联盟，中国微生物学会医学微生物学与免疫学专业委员会，中国生物工程学会噬菌体技术专业委员会，等.预防及治疗用噬菌体质量标准专家共识[J].中国生物工程杂志，2024,44(1):152-158.DOI:10. 13523/j. cb. 2310037.
[6]世界卫生组织著．上海市供水调度监测中心，上海交通大学译，饮用水水质准则第4版．上海交通大学出版社．2014. 12.177-178
[7] Ivanova N, Sorokin A, Anderson I, et al. Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. Nature. 2003;423(6935):87-91. doi:10. 1038/nature01582
[8]王岙，张炜煜，张立夫，等.炭疽芽孢杆菌检测实验室生物安全风险评估与控制[J].中国卫生工程学，2024,23(05):717-720. DOI:10. 19937/j. issn. 1671-4199. 2024. 05. 046.
[9]杨艳华，吕鹏，陈克平.蜡样芽孢杆菌主要毒素及检测方法的研究进展[J].生命科学研究，2021,25(06):471-478+487.DOI:10. 16605/j.cnki.1007-7847. 2021. 04. 0147
[10]黄虎翔，王辉，张万明.解淀粉芽孢杆菌对婴幼儿潜在致病性的研究[J].临床儿科杂志，2010,28(2):190-192. DOI:10. 3969/j. issn. 1000-3606. 2010. 02. 024..
[11]Ghelardi E, Celandroni F, Salvetti S, et al. Bacillus thuringiensis pulmonary infection:critical role for bacterial membrane-damaging toxins and host neutrophils[J]. Microbes Infect. 2007;9(5):591-598. DOI:10. 1016/j. micinf. 2007. 02. 001
[12]Kamal SM, Rashid AK, Bakar MA, et al. Anthrax:an update[J]. Asian Pac J Trop Biomed. 2011;1(6):496-501. DOI:10. 1016/S2221-1691(11)60109-3
[13]闻玉梅.现代医学微生物学[M].上海：上海医科大学出版社，1999:441-448.
[14]Datta KK, Singh J. Anthrax[J]. Indian J Pediatr.2002;69(1):49-56. doi:10. 1007/BF02723777
[15]雷连成.炭疽杆菌生物战剂的研究现状[C]//中国畜牧兽医学会家畜传染病分会，解放军军需大学.人畜共患传染病防治研究新成果汇编.解放军军需大学军事兽医系；，2004:8.
[16]Kalamas AG. Anthrax[J]. Anesthesiol Clin North Am. 2004; 22(3):533-vii. DOI:10. 1016/j.atc. 2004. 05. 009
[17]Young JA, Collier RJ. Anthrax toxin:receptor binding, internalization, pore formation, and translocation[J]. Annu Rev Biochem. 2007;76:243-265.DOI:10. 1146/annurev.biochem. 75. 103004. 142728
[18]Bann JG. Anthrax toxin protective antigen--insights into molecular switching from prepore to pore[J]. Protein Sci. 2012;21(1):1-12. DOI:10. 1002/pro. 752
[19]Piggot PJ, Hilbert DW. Sporulation of Bacillus subtilis[J]. Curr Opin Microbiol. 2004;7(6):579-586. DOI:10. 1016/j. mib. 2004. 10. 001
[20]龚慧.猪源益生芽孢杆菌的筛选及发酵工艺研究[D].洛阳：河南科技大学，2014.
[21]Beattie S H, Williams A G. Detection of toxins[M].Encyclopedia of Food Microbiology, 2000, 141-149.
[22]陆湘华，崔昌，王远萍，等.蜡样芽孢杆菌食物中毒的研究进展[J].传染病信息，2015(4):251-254. DOI:10. 3969/j. issn. 1007-8134. 2015. 04. 017.
[23]种婷.蜡样芽孢杆菌呕吐毒素Cereulide研究进展[J].现代食品，2022,28(10):61-63. DOI:10. 16736/j. cnki.cn41-1434/ts. 2022. 10. 017.
[24]王霄晔，任婧寰，王哲，等. 2017年全国食物中毒事件流行特征分析[J].疾病监测，2018,33(5):359-364.DOI:10. 3784/j. issn. 1003-9961. 2018. 05. 004..
[25]胡金宇，王锐. 2010—2019年全国细菌性食物中毒事件流行病学特征分析[J].中国食品卫生杂志，2023,35(08):1225-1230. DOI:10. 13590/j. cjfh. 2023. 08. 014
[26]Bennett SD, Walsh KA, Gould LH. Foodborne disease outbreaks caused by Bacillus cereus, Clostridium perfringens, and Staphylococcus aureus--United States,1998-2008[J]. Clin Infect Dis. 2013;57(3):425-433.DOI:10. 1093/cid/cit244
[27]傅杰青.究竟是谁发现了噬菌体？[J].自然辩证法通讯，1985(06):50-54+80. DOI:CNKI:SUN:ZRBT. 0. 1985-06-008
[28]Cowles PB. A Bacteriophage for B. anthracis[J]. J Bacteriol. 1931;21(3):161-166. DOI:10. 1128/jb. 21. 3. 161-166. 1931
[29]BROWN ER, CHERRY WB. Specific identification of Bacillus anthracis by means of a variant bacteriophage[J]. J Infect Dis. 1955;96(1):34-39. DOI:10. 1093/infdis/96. 1. 34
[30]Inal JM, Karunakaran KV. phi 20, a temperate bacteriophage isolated from Bacillus anthracis exists as a plasmidial prophage[J]. Curr Microbiol. 1996;32(4):171-175. DOI:10. 1007/s002849900030
[31]Walter MH, Baker DD. Three Bacillus anthracis bacteriophages from topsoil[J]. Curr Microbiol. 2003;47(1):55-58. DOI:10. 1007/s00284-002-3899-y
[32]Schuch R, Pelzek AJ, Kan S, et al. Prevalence of Bacillus anthracis-like organisms and bacteriophages in the intestinal tract of the earthworm Eisenia fetida[J].Appl Environ Microbiol. 2010;76(7):2286-2294.DOI:10. 1128/AEM. 02518-09
[33]Kan S, Fornelos N, Schuch R, et al. Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on Bacillus anthracis[J]. J Bacteriol. 2013;195(19):4355-4364. DOI:10. 1128/JB. 00655-13
[34]Alkalay S, Sternberg S, Coppenhagen-Glazer S, et al.Complete Genome Sequences of Three Bacillus anthracis Bacteriophages[J]. Genome Announc. 2018;6(1):e01164-17. Published 2018 Jan 4. DOI:10. 1128/genomeA. 01164-17
[35]Hassim A, Lekota KE, van Dyk DS, et al. A Unique Isolation of a Lytic Bacteriophage Infected Bacillus anthracis Isolate from Pafuri, South Africa.Microorganisms. 2020;8(6):932. Published 2020 Jun20. doi:10. 3390/microorganisms8060932
[36]Nakonieczna A, Rutyna P, Fedorowicz M, et al. Three Novel Bacteriophages, J5a, F16Ba, and z1a, Specific for Bacillus anthracis, Define a New Clade of Historical Wbeta Phage Relatives. Viruses. 2022;14(2):213.Published 2022 Jan 21. doi:10. 3390/v14020213
[37]董树林，张守让，孙建鑫，等.炭疽杆菌噬菌体AP631株的分离和鉴定[J].微生物学报，1979,19(02):218-219. DOI:10. 13343/j. cnki. wsxb. 1979. 02. 012.
[38]王秉翔，张守让，虞雪梅，等.炭疽芽孢杆菌噬菌体AP631的生物学特性检测[J].病毒学报，1992(02):193-194. DOI:CNKI:SUN:BDXB. 0. 1992-02-018.
[39]董树林，王秉翔．炭疽[M]．西安：陕西科学技术出版社，2004:79-87.
[40]Makky S, Dawoud A, Safwat A, et al. The bacteriophage decides own tracks:When they are with or against the bacteria. Curr Res Microb Sci. 2021;2:100050. Published 2021 Jul 31. DOI:10. 1016/j.crmicr. 2021. 100050
[41]张慧娟，刘东立，贺莉，等. AP631炭疽噬菌体裂解蜡样芽胞杆菌的发现和鉴定[J].中国人兽共患病学报，2016,32(6):507-511. DOI:10. 3969/j. issn. 1002-2694. 2016. 06. 001.
[42]Li L, Zhang H, Jin H, et al. Identification and characterization of two Bacillus anthracis bacteriophages[J]. Arch Virol. 2024;169(7):134. Published 2024Jun 5. doi:10. 1007/s00705-024-06005-7
[43]Schofield DA, Westwater C. Phage-mediated bioluminescent detection of Bacillus anthracis[J]. J Appl Microbiol. 2009;107(5):1468-1478. doi:10. 1111/j. 1365-2672. 2009. 04332. x
[44]Schofield DA, Sharp NJ, Vandamm J, et al. Bacillus anthracis diagnostic detection and rapid antibiotic susceptibility determination using′bioluminescent′reporter phage[J]. J Microbiol Methods. 2013;95(2):156-161. doi:10. 1016/j. mimet. 2013. 08. 013
[45]Reiman RW, Atchley DH, Voorhees KJ. Indirect detection of Bacillus anthracis using real-time PCR to detect amplified gamma phage DNA[J]. J Microbiol Methods. 2007;68(3):651-653. doi:10. 1016/j.mimet. 2006. 11. 004
[46]Fujinami Y, Hirai Y, Sakai I, et al. Sensitive detection of Bacillus anthracis using a binding protein originating from gamma-phage[J]. Microbiol Immunol. 2007;51(2):163-169. doi:10. 1111/j. 1348-0421. 2007.tb03894. x
[47]Cox CR, Jensen KR, Mondesire RR, Voorhees KJ.Rapid detection of Bacillus anthracis by γ phage amplification and lateral flow immunochromatography. J Microbiol Methods. 2015;118:51-56. doi:10. 1016/j.mimet. 2015. 08. 011
[48]Braun P, Rupprich N, Neif D, et al. Enzyme-Linked Phage Receptor Binding Protein Assays(ELPRA)Enable Identification of Bacillus anthracis Colonies.Viruses. 2021;13(8):1462. Published 2021 Jul 27.doi:10. 3390/v13081462
[49]袁文源，林焱，朱伟云.一种实验室去除噬菌体制剂内毒素方法的建立[J].病毒学报，2024,40(04):823-829. DOI:10. 13242/j. cnki. bingduxuebao. 004492.
[50]Kwiatek M, Parasion S, Nakonieczna A. Therapeutic bacteriophages as a rescue treatment for drug-resistant infections-an in vivo studies overview[J]. J Appl Microbiol. 2020;128(4):985-1002. doi:10. 1111/jam. 14535
[51]Carter MQ, Pham A, Du WX, et al. Differential induction of Shiga toxin in environmental Escherichia coli O145:H28 strains carrying the same genotype as the outbreak strains. Int J Food Microbiol. 2021;339:109029. DOI:10. 1016/j. ijfoodmicro. 2020. 109029
[52]Ding B, Li Q, Guo M, et al. Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice. Front Microbiol.2018;9:1553. Published 2018 Jul 23. doi:10. 3389/fmicb. 2018. 01553
[53]Lin J, Du F, Long M, et al. Limitations of Phage Therapy and Corresponding Optimization Strategies:A Review. Molecules. 2022;27(6):1857. Published2022 Mar 13. doi:10. 3390/molecules27061857
[54]Schuch R, Nelson D, Fischetti VA. A bacteriolytic agent that detects and kills Bacillus anthracis. Nature.2002;418(6900):884-889. doi:10. 1038/nature01026
[55]Heselpoth RD, Owens JM, Nelson DC. Quantitative analysis of the thermal stability of the gamma phage endolysin PlyG:a biophysical and kinetic approach to assaying therapeutic potential. Virology. 2015;477:125-132. doi:10. 1016/j. virol. 2014. 11. 003
[56]李晓静，张豪，付学奇，等.炭疽杆菌噬菌体裂解酶基因在大肠杆菌中的表达及鉴定[J].生物工程学报，2005(02):216-219. DOI:10. 13345/j. cjb. 2005. 02. 010.
[57]Kikkawa HS, Ueda T, Suzuki S, et al.Characterization of the catalytic activity of the gammaphage lysin, PlyG, specific for Bacillus anthracis.FEMS Microbiol Lett. 2008;286(2):236-240. doi:10. 1111/j. 1574-6968. 2008. 01280. x
[58]Yoong P, Schuch R, Nelson D, et al. PlyPH, a bacteriolytic enzyme with a broad pH range of activity and lytic action against Bacillus anthracis. J Bacteriol.2006; 188(7):2711-2714. doi:10. 1128/JB. 188. 7. 2711-2714. 2006
[59]Mundra RV, Mehta KK, Wu X, et al. Enzyme-driven Bacillus spore coat degradation leading to spore killing[J]. Biotechnol Bioeng. 2014;111(4):654-663. doi:10. 1002/bit. 25132
[60]Park S, Jun SY, Kim CH, et al. Characterisation of the antibacterial properties of the recombinant phage endolysins AP50-31 and LysB4 as potent bactericidal agents against Bacillus anthracis. Sci Rep. 2018;8(1):18. Published 2018 Jan 8. doi:10. 1038/s41598-017-18535-z
[61]Schuch R, Pelzek AJ, Nelson DC, et al. The PlyB Endolysin of Bacteriophage vB_BanS_Bcp1 Exhibits Broad-Spectrum Bactericidal Activity against Bacillus cereus Sensu Lato Isolates[J]. Appl Environ Microbiol.2019;85(9):e00003-19. Published 2019 Apr 18. DOI:10. 1128/AEM. 00003-19
[62]Nakonieczna A, Topolska-Wo?A，?obocka M. New bacteriophage-derived lysins, LysJ and LysF, with the potential to control Bacillus anthracis[J]. Appl Microbiol Biotechnol. 2024;108(1):76. DOI:10. 1007/s00253-023-12839-z
[63]Nakonieczna A, Abramowicz K, Kwiatek M, et al.Lysins as a powerful alternative to combat Bacillus anthracis. Appl Microbiol Biotechnol. 2024;108(1):366. Published 2024 Jun 8. DOI:10. 1007/s00253-024-13194-3
[64]Schuch R, Fischetti VA. Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis:implications for evolution of environmental fitness and antibiotic resistance[J]. J Bacteriol. 2006;188(8):3037-3051. doi:10. 1128/JB. 188. 8. 3037-3051. 2006
[65]Fulmer P A. Susceptibility of Bacillus anthracis to Gamma and Cherry bacteriophage[D]. Louisiana State University, Baton Rouge, La, 2003.
[66]Gillis A, Mahillon J. Phages preying on Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis:past, present and future. Viruses. 2014;6(7):2623-2672. Published 2014 Jul 9. DOI:10. 3390/v6072623
[67]Minakhin L, Semenova E, Liu J, et al. Genome sequence and gene expression of Bacillus anthracis bacteriophage Fah. J Mol Biol. 2005;354(1):1-15.DOI:10. 1016/j. jmb. 2005. 09. 052
[68]Nagy E, Prágai B, Ivánovics G. Characteristics of phage AP50, an RNA phage containing phospholipids. J Gen Virol. 1976;32(1):129-132. DOI:10. 1099/0022-1317-32-1-129
[69]Lee WJ, Billington C, Hudson JA, et al. Isolation and characterization of phages infecting Bacillus cereus. Lett Appl Microbiol. 2011;52(5):456-464. doi:10. 1111/j. 1472-765X. 2011. 03023. x
[70]方媛，季秀玲，张琦，等.一株蜡样芽孢杆菌低温噬菌体的分离及生物学特征[J].中国微生态学杂志，2013,25(07):745-749. DOI:10. 13381/j. cnki.cjm. 2013. 07. 001
[71]Ji X, Zhang C, Fang Y, et al. Isolation and characterization of glacier VMY22, a novel lytic coldactive bacteriophage of Bacillus cereus. Virol Sin. 2015;30(1):52-58. doi:10. 1007/s12250-014-3529-4
[72]Na H, Kong M, Ryu S. Characterization of LysPBC4,a novel Bacillus cereus-specific endolysin of bacteriophage PBC4. FEMS Microbiol Lett. 2016;363(12):fnw092. DOI:10. 1093/femsle/fnw092
[73]Peng Q, Yuan Y. Characterization of a novel phage infecting the pathogenic multidrug-resistant Bacillus cereus and functional analysis of its endolysin. Appl Microbiol Biotechnol. 2018;102(18):7901-7912. doi:10. 1007/s00253-018-9219-7
[74]Kong L, Ding Y, Wu Q, et al. Genome sequencing and characterization of three Bacillus cereus-specific phages,DK1, DK2, and DK3. Arch Virol. 2019;164(7):1927-1929. DOI:10. 1007/s00705-019-04258-1
[75]Li C, Yuan X, Li N, et al. Isolation and Characterization of Bacillus cereus Phage vB_BcePDLc1 Reveals the Largest Member of theΦ29-Like Phages[J]. Microorganisms. 2020;8(11):1750.Published 2020 Nov 7. DOI:10. 3390/microorganisms8111750
[76]Ruan C, Niu X, Xiong G, et al. Phenotypic and genotypic characterization of the new Bacillus cereus phage SWEP1. Arch Virol. 2021;166(11):3183-3188. DOI:10. 1007/s00705-021-05222-8
[77]Huang Z, Yuan X, Zhu Z, et al. Isolation and characterization of Bacillus cereus bacteriophage DZ1and its application in foods. Food Chem. 2024;431:137128. DOI:10. 1016/j. foodchem. 2023. 137128
[78]Smeesters PR, Drèze PA, Bousbata S, et al.Characterization of a novel temperate phage originating from a cereulide-producing Bacillus cereus strain. Res Microbiol. 2011;162(4):446-459. doi:10. 1016/j.resmic. 2011. 02. 009
[79]Lee YD, Park JH. Genome organization of temperate phage 11143 from emetic Bacillus cereus NCTC11143.J Microbiol Biotechnol. 2012;22(5):649-653. doi:10. 4014/jmb. 1110. 10065
[80]Ahmed R, Sankar-Mistry P, Jackson S, et al. Bacillus cereus phage typing as an epidemiological tool in outbreaks of food poisoning[J]. Journal of Clinical Microbiology, 1995, 33(3):636-640. DOI:10. 1128/JCM. 33. 3. 636-640. 1995.
[81]Ripp S. Bacteriophage-based pathogen detection[A]//BelkinS, GuMB. Whole Cell Sensing System II:Applications[M]. Berlin:Springer,2009,118:65-84
[82]Kong M, Sim J, Kang T, et al. A novel and highly specific phage endolysin cell wall binding domain for detection of Bacillus cereus. Eur Biophys J. 2015;44(6):437-446. doi:10. 1007/s00249-015-1044-7
[83]Yuan X, Zhu Z, Huang Z, et al. Engineered lytic phage of Bacillus cereus and its application in milk. Int J Food Microbiol. 2023; 405:110339. DOI:10. 1016/j.ijfoodmicro. 2023. 110339
[84]Park J, Yun J, Lim JA, et al. Characterization of an endolysin, LysBPS13, from a Bacillus cereus bacteriophage[J]. FEMS Microbiology Letters, 2012(1):76-83. DOI:10. 1111/j. 1574-6968. 2012. 02578. x.
[85]Son B, Yun J, Lim JA, et al. Characterization of LysB4, an endolysin from the Bacillus cereus-infecting bacteriophage B4. BMC Microbiol. 2012;12:33.Published 2012 Mar 15. doi:10. 1186/1471-2180-12-33
[86]Kong M, Na H, Ha NC, et al. LysPBC2, a Novel Endolysin Harboring a Bacillus cereus Spore Binding Domain. Appl Environ Microbiol. 2019;85(5):e02462-18. Published 2019 Feb 20. doi:10. 1128/AEM. 02462-18
[87]Lee JH, Shin H, Son B, et al. Characterization and complete genome sequence of a virulent bacteriophage B4 infecting food-borne pathogenic Bacillus cereus.Arch Virol. 2013;158(10):2101-2108. doi:10. 1007/s00705-013-1719-2
[88]Kong M, Ryu S. Bacteriophage PBC1 and its endolysin as an antimicrobial agent against Bacillus cereus. Appl Environ Microbiol. 2015;81(7):2274-2283. doi:10. 1128/AEM. 03485-14
[89]朱云，张旭华，马强，等.噬菌体生物活性物质及其应用研究进展[J].医学动物防制，2023,39(11):1113-1118. DOI:10. 7629/yxdwfz202311022.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.240152
中图分类号:Q939.48
引用信息:
[1]秦欣雨,于彬彬,王鹏,等.致病性芽孢杆菌噬菌体的分离鉴定及其应用现状[J].病毒学报,2025,41(04):1076-1086.DOI:10.13242/j.cnki.bingduxuebao.240152.
基金信息:
云南省科技厅科技计划项目（项目号：202305AD160011）,题目：技术创新人才培养对象项目钟佑宏; 大理州科技计划项目（项目号：D2022ZA0116）,题目：一株新分炭疽噬菌体生物学特性及其基因组研究~~