2013 01 v.29 71-75
埃博拉病毒侵染细胞机制的研究进展
基金项目(Foundation):
东南大学教学改革研究项目(2010-079);;
东南大学大学生科研训练(SRTP)项目(11412003)
邮箱(Email):
DOI:
10.13242/j.cnki.bingduxuebao.002354
中文作者单位:
东南大学医学院;
摘要(Abstract):
埃博拉病毒能在人类和非人灵长类中引起严重的埃博拉出血热,病死率可高达90%,并且目前还没有针对埃博拉病毒有效的疫苗或者是治疗手段。面对埃博拉病毒带来的挑战,针对埃博拉病毒的相关研究已经成为病毒学的热点问题。其中,关于埃博拉病毒侵染细胞机制的科学研究对于开发病毒疫苗以及新型治疗药物有非常关键的作用。因此,本综述拟就埃博拉病毒侵染细胞机制方面的研究进展进行总结。
关键词(KeyWords):
埃博拉病毒;;感染机制;;研究进展
| 5,737 | 16 | 40 |
| 下载次数 | 被引频次 | 阅读次数 |
参考文献
[1]Ascenzi P,Bocedi A,Heptonstall J,et al.Ebolavirusand Marburgvirus:insight the Filoviridae family[J].Mol Aspects Med,2008,29(3):151-185.
[2]Qiu X,Alimonti J B,Melito P L,et al.Characteriza-tion of Zaire ebolavirus glycoprotein-specific monoclonalantibodies[J].Clin Immunol,2011,141(2):218-227.
[3]Kuhn J H,Becker S,Ebihara H,et al.Proposal for arevised taxonomy of the family Filoviridae:classifica-tion,names of taxa and viruses,and virus abbreviations[J].Arch Virol,2010,155(12):2083-2103.
[4]Leroy E M,Becquart P,Wauquier N,et al.Evidencefor Ebola virus superantigen activity[J].J Virol,2011,85(8):4041-4042.
[5]Nanbo A,Imai M,Watanabe S,et al.Ebolavirus is in-ternalized into host cells via macropinocytosis in a viralglycoprotein-dependent manner[J/OL].PLoS Pathog,2010,6(9):e1001121.
[6]Halfmann P,Kim J H,Ebihara H,et al.Generation ofbiologically contained Ebola viruses[J].Proc Natl AcadSci U S A,2008,105(4):1129-1133.
[7]Wool-Lewis R J,Bates P.Characterization of Ebola vi-rus entry by using pseudotyped viruses:identification ofreceptor-deficient cell lines[J].J Virol,1998,72(4):3155-3160.
[8]Martinez O,Leung L W,Basler C F.The role of anti-gen-presenting cells in filoviral hemorrhagic fever:Gapsin current knowledge[J].Antiviral Res,2012,93(3):416-428.
[9]Radoshitzky S R,Warfield K L,et al.Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebo-lavirus cell entry[J].J Virol,2011,85(17):8502-8513.
[10]Geisbert T W,Feldmann H.Recombinant vesicularstomatitis virus-based vaccines against Ebola and Mar-burg virus infections[J].J Infect Dis,2011,204Suppl3:S1075-1081.
[11]Sanchez A.Analysis of filovirus entry into vero e6cells,using inhibitors of endocytosis,endosomal acidi-fication,structural integrity,and cathepsin(B and L)activity[J].J Infect Dis,2007,196Suppl 2:S251-258.
[12]Aleksandrowicz P,Marzi A,Biedenkopf N,et al.Ebola virus enters host cells by macropinocytosis andclathrin-mediated endocytosis[J].J Infect Dis,2011,204Suppl 3:S957-967.
[13]Mercer J,Helenius A.Virus entry by macropinocyto-sis[J].Nat Cell Biol,2009,11(5):510-520.
[14]Swanson J A.Shaping cups into phagosomes andmacropinosomes[J].Nat Rev Mol Cell Biol,2008,9(8):639-649.
[15]Shimojima M,Takada A,Ebihara H,et al.Tyro3family-mediated cell entry of Ebola and Marburg viru-ses[J].J Virol,2006,80(20):10109-10116.
[16]姚鹏程,叶恭银.网格蛋白介导的内吞作用机制[J].生命科学研究,2003,7(2):22-25.
[17]Empig C J,Goldsmith M A.Association of the caveolavesicular system with cellular entry by filoviruses[J].J Virol,2002,76(10):5266-5270.
[18]Bhattacharyya S,Warfield K L,Ruthel G,et al.Ebolavirus uses clathrin-mediated endocytosis as an entrypathway[J].Virology,2010,401(1):18-28.
[19]Saeed M F,Kolokoltsov A A,Albrecht T,et al.Cel-lular entry of ebola virus involves uptake by a macropi-nocytosis-like mechanism and subsequent traffickingthrough early and late endosomes[J/OL].PLoSPathog,2010,6(9):e1001110.
[20]Lim J P,Gleeson P A.Macropinocytosis:an endocyticpathway for internalising large gulps[J].ImmunolCell Biol,2011,89(8):836-843.
[21]Richter T,Floetenmeyer M,Ferguson C,et al.High-resolution 3Dquantitative analysis of caveolar ultra-structure and caveola-cytoskeleton interactions[J].Traffic,2008,9(6):893-909.
[22]Traub L M.Clathrin couture:fashioning distinctivemembrane coats at the cell surface[J/OL].PLoS Biol,2009,7(9):e1000192.
[23]Bale S,Liu T,Li S,Wang Y,et al.Ebola Virus Gly-coprotein Needs an Additional Trigger,beyond Prote-olytic Priming for Membrane Fusion[J/OL].PLoSNegl Trop Dis,2011,5(11):e1395.
[24]Schornberg K,Matsuyama S,Kabsch K,et al.Role ofendosomal cathepsins in entry mediated by the Ebolavirus glycoprotein[J].J Virol,2006,80(8):4174-4178.
[25]Brecher M,Schornberg K L,Delos S E,et al.Cathep-sin Cleavage Potentiates the Ebola Virus Glycoproteinto Undergo a Subsequent Fusion Relevant Conforma-tional Change[J].J Virol,2011,86(1):364-72.
[26]Chandran K,Sullivan N J,Felbor U,et al.Endosomalproteolysis of the Ebola virus glycoprotein is necessaryfor infection[J].Science,2005,308(5728):1643-1645.
[27]Martinez O,Johnson J,Manicassamy B,et al.ZaireEbola virus entry into human dendritic cells is insensi-tive to cathepsin L inhibition[J].Cell Microbiol,2010,12(2):148-157.
[28]Carette J E,Raaben M,Wong A C,et al.Ebola virusentry requires the cholesterol transporter Niemann-Pick C1[J].Nature,2011,477(7364):340-343.
[29]Cote M,Misasi J,Ren T,et al.Small molecule inhibi-tors reveal Niemann-Pick C1is essential for Ebolavirus infection[J].Nature,2011,477(7364):344-348.
[30]Chan S Y,Empig C J,Welte F J,et al.Folate recep-tor-alpha is a cofactor for cellular entry by Marburgand Ebola viruses[J].Cell,2001,106(1):117-126.
[31]Simmons G,Rennekamp A J,Chai N,et al.Folatereceptor alpha and caveolae are not required for Ebolavirus glycoprotein-mediated viral infection[J].J Virol,2003,77(24):13433-13438.
[32]Takada A.Filovirus tropism:cellular molecules forviral entry[J].Front Microbiol,2012,3:34.
[33]Pourrut X,Kumulungui B,Wittmann T,et al.Thenatural history of Ebola virus in Africa[J].MicrobesInfect,2005,7(7-8):1005-1014.
[2]Qiu X,Alimonti J B,Melito P L,et al.Characteriza-tion of Zaire ebolavirus glycoprotein-specific monoclonalantibodies[J].Clin Immunol,2011,141(2):218-227.
[3]Kuhn J H,Becker S,Ebihara H,et al.Proposal for arevised taxonomy of the family Filoviridae:classifica-tion,names of taxa and viruses,and virus abbreviations[J].Arch Virol,2010,155(12):2083-2103.
[4]Leroy E M,Becquart P,Wauquier N,et al.Evidencefor Ebola virus superantigen activity[J].J Virol,2011,85(8):4041-4042.
[5]Nanbo A,Imai M,Watanabe S,et al.Ebolavirus is in-ternalized into host cells via macropinocytosis in a viralglycoprotein-dependent manner[J/OL].PLoS Pathog,2010,6(9):e1001121.
[6]Halfmann P,Kim J H,Ebihara H,et al.Generation ofbiologically contained Ebola viruses[J].Proc Natl AcadSci U S A,2008,105(4):1129-1133.
[7]Wool-Lewis R J,Bates P.Characterization of Ebola vi-rus entry by using pseudotyped viruses:identification ofreceptor-deficient cell lines[J].J Virol,1998,72(4):3155-3160.
[8]Martinez O,Leung L W,Basler C F.The role of anti-gen-presenting cells in filoviral hemorrhagic fever:Gapsin current knowledge[J].Antiviral Res,2012,93(3):416-428.
[9]Radoshitzky S R,Warfield K L,et al.Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebo-lavirus cell entry[J].J Virol,2011,85(17):8502-8513.
[10]Geisbert T W,Feldmann H.Recombinant vesicularstomatitis virus-based vaccines against Ebola and Mar-burg virus infections[J].J Infect Dis,2011,204Suppl3:S1075-1081.
[11]Sanchez A.Analysis of filovirus entry into vero e6cells,using inhibitors of endocytosis,endosomal acidi-fication,structural integrity,and cathepsin(B and L)activity[J].J Infect Dis,2007,196Suppl 2:S251-258.
[12]Aleksandrowicz P,Marzi A,Biedenkopf N,et al.Ebola virus enters host cells by macropinocytosis andclathrin-mediated endocytosis[J].J Infect Dis,2011,204Suppl 3:S957-967.
[13]Mercer J,Helenius A.Virus entry by macropinocyto-sis[J].Nat Cell Biol,2009,11(5):510-520.
[14]Swanson J A.Shaping cups into phagosomes andmacropinosomes[J].Nat Rev Mol Cell Biol,2008,9(8):639-649.
[15]Shimojima M,Takada A,Ebihara H,et al.Tyro3family-mediated cell entry of Ebola and Marburg viru-ses[J].J Virol,2006,80(20):10109-10116.
[16]姚鹏程,叶恭银.网格蛋白介导的内吞作用机制[J].生命科学研究,2003,7(2):22-25.
[17]Empig C J,Goldsmith M A.Association of the caveolavesicular system with cellular entry by filoviruses[J].J Virol,2002,76(10):5266-5270.
[18]Bhattacharyya S,Warfield K L,Ruthel G,et al.Ebolavirus uses clathrin-mediated endocytosis as an entrypathway[J].Virology,2010,401(1):18-28.
[19]Saeed M F,Kolokoltsov A A,Albrecht T,et al.Cel-lular entry of ebola virus involves uptake by a macropi-nocytosis-like mechanism and subsequent traffickingthrough early and late endosomes[J/OL].PLoSPathog,2010,6(9):e1001110.
[20]Lim J P,Gleeson P A.Macropinocytosis:an endocyticpathway for internalising large gulps[J].ImmunolCell Biol,2011,89(8):836-843.
[21]Richter T,Floetenmeyer M,Ferguson C,et al.High-resolution 3Dquantitative analysis of caveolar ultra-structure and caveola-cytoskeleton interactions[J].Traffic,2008,9(6):893-909.
[22]Traub L M.Clathrin couture:fashioning distinctivemembrane coats at the cell surface[J/OL].PLoS Biol,2009,7(9):e1000192.
[23]Bale S,Liu T,Li S,Wang Y,et al.Ebola Virus Gly-coprotein Needs an Additional Trigger,beyond Prote-olytic Priming for Membrane Fusion[J/OL].PLoSNegl Trop Dis,2011,5(11):e1395.
[24]Schornberg K,Matsuyama S,Kabsch K,et al.Role ofendosomal cathepsins in entry mediated by the Ebolavirus glycoprotein[J].J Virol,2006,80(8):4174-4178.
[25]Brecher M,Schornberg K L,Delos S E,et al.Cathep-sin Cleavage Potentiates the Ebola Virus Glycoproteinto Undergo a Subsequent Fusion Relevant Conforma-tional Change[J].J Virol,2011,86(1):364-72.
[26]Chandran K,Sullivan N J,Felbor U,et al.Endosomalproteolysis of the Ebola virus glycoprotein is necessaryfor infection[J].Science,2005,308(5728):1643-1645.
[27]Martinez O,Johnson J,Manicassamy B,et al.ZaireEbola virus entry into human dendritic cells is insensi-tive to cathepsin L inhibition[J].Cell Microbiol,2010,12(2):148-157.
[28]Carette J E,Raaben M,Wong A C,et al.Ebola virusentry requires the cholesterol transporter Niemann-Pick C1[J].Nature,2011,477(7364):340-343.
[29]Cote M,Misasi J,Ren T,et al.Small molecule inhibi-tors reveal Niemann-Pick C1is essential for Ebolavirus infection[J].Nature,2011,477(7364):344-348.
[30]Chan S Y,Empig C J,Welte F J,et al.Folate recep-tor-alpha is a cofactor for cellular entry by Marburgand Ebola viruses[J].Cell,2001,106(1):117-126.
[31]Simmons G,Rennekamp A J,Chai N,et al.Folatereceptor alpha and caveolae are not required for Ebolavirus glycoprotein-mediated viral infection[J].J Virol,2003,77(24):13433-13438.
[32]Takada A.Filovirus tropism:cellular molecules forviral entry[J].Front Microbiol,2012,3:34.
[33]Pourrut X,Kumulungui B,Wittmann T,et al.Thenatural history of Ebola virus in Africa[J].MicrobesInfect,2005,7(7-8):1005-1014.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.002354
中图分类号:R373.9
引用信息:
[1]石明,沈宇清.埃博拉病毒侵染细胞机制的研究进展[J].病毒学报,2013,29(01):71-75.DOI:10.13242/j.cnki.bingduxuebao.002354.
基金信息:
东南大学教学改革研究项目(2010-079);; 东南大学大学生科研训练(SRTP)项目(11412003)
暂无数据