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肠道病毒可导致多种疾病,严重损害机体健康。为抵抗病毒侵染,宿主会利用细胞凋亡清除被感染的细胞和病毒。肠道病毒在与宿主细胞的斗争中,进化出了平衡细胞凋亡的策略以利于自身的复制和传播。本文讨论了几种肠道病毒调节细胞凋亡的途径,为进一步阐明肠道病毒急性感染相关机制和抗病毒药物的研发提供了理论基础。
Abstract:Enteroviruses can cause a variety of diseases that may seriously damage the health of the organism.To resist viral infestation, hosts use apoptosis to remove infected cells and viruses. In their struggle with host cells, enteroviruses have evolved strategies to balance apoptosis to facilitate their own replication and propagation. This paper discusses some pathways by which several enteroviruses regulate apoptosis, aiming to provide a theoretical basis for further elucidation of the mechanism associated with acute infection by enteroviruses and development of antiviral drugs.
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基本信息:
DOI:10.13242/j.cnki.bingduxuebao.004502
中图分类号:R373.2
引用信息:
[1]张哲,王涛,王志云.肠道病毒与细胞凋亡的关系[J].病毒学报,2023,39(06):1731-1739.DOI:10.13242/j.cnki.bingduxuebao.004502.