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HIV-Tat蛋白是由HIV-1病毒感染细胞后分泌的反式转录激活因子,在HIV感染神经损害中发挥重要作用,是引起艾滋病相关脑病的重要致病因子。自噬即自我吞噬,主要作用是供给机体营养,但异常自噬则引起细胞死亡。HIV-Tat蛋白可以诱导神经细胞自噬,从而使细胞死亡,但引起自噬的机制及信号转导通路不清楚。本文主要从HIV-Tat蛋白诱导神经细胞自噬的机制、信号转导通路等方面进行综述,旨在为进一步研究HIV-Tat蛋白与细胞自噬的关系及寻找新的治疗药物靶点提供参考。
Abstract：The Tat protein of human immunodeficiency virus type-1(HIV-Tat protein),as a transactivator of transcription,is released from HIV-1-infected cells.HIV-Tat protein plays an important part in the pathogenesis of HIV-associated neurocognitive disorders."Autophagy"is a critical mechanism that ensures the appropriate homeostasis and function of cells.However,extensive or inappropriate activation of autophagy results in autophagic cell death.Several studies have shown that HIV-Tat protein can induce autophagy in neuron cells,but the mechanism of regulation and signaling pathways are not known.Here,the mechanism of regulation and signaling pathways of autophagy by HIV-Tat that induce neurotoxicity are reviewed to provide reference materials for the further study of HIV-Tat protein and autophagy.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.003133
中图分类号:R512.91
引用信息:
[1]李娟,杨根梦,仝品芬,等.HIV-Tat蛋白诱导神经细胞自噬的研究进展[J].病毒学报,2017,33(02):269-273.DOI:10.13242/j.cnki.bingduxuebao.003133.
基金信息:
国家科技支撑计划项目(2014BA101B01),题目:实验用树鼩的标准化研究和人类重大疾病树鼩模型创建与应用集成示范;; 国家自然科学基金项目(81560303),题目:Nrf2通路在MA与HIV-Tat蛋白协同诱导多巴胺能神经元自噬中的作用及机制;; 云南省科技厅-昆明医科大学应用基础研究联合专项(2013FB127),题目:氧化应激在MA与HIV-Tat蛋白协同诱导多巴胺能神经元自体吞噬中的作用及分子机制;; 昆明医科大学毒品滥用法医病理学科技创新团队(CXTD201604)
2017-03-29
2017-03-29
2017-03-29