427 | 3 | 64 |
下载次数 | 被引频次 | 阅读次数 |
呼吸道合胞病毒是所有2岁以下儿童感染的重要病原,近年来多项研究表明,呼吸道合胞病毒感染与脂质代谢关系密切,在肺炎的致病机制中发挥重要作用,该文综述脂质在呼吸道合胞病毒生命周期中的重要性及呼吸道合胞病毒感染与脂质代谢的相互作用。
Abstract:Respiratory syncytial virus(RSV) is an important pathogen in all children under 2 years old. In recent years, many studies have shown that respiratory syncytial virus infection is closely related to lipid metabolism and plays an important role on the pathogenesis of pneumonia. This article reviews the importance of lipids in the life cycle of respiratory syncytial virus and the interaction between respiratory syncytial virus infection and lipid metabolism.
[1] Machado V B, Marostica de Sa J, Miranda Prado A K,Alves de Toledo K, Regasini L O, Pereira de Souza F,Caruso I P, Fossey M A. Biophysical and flavonoidbinding studies of the G protein ectodomain of group A human respiratory syncytial virus[J/OL]. Heliyon,2019, 5(3):e01394. DOI:10.1016/j. heliyon. 2019.e01394.
[2] Shan J, Qian W, Shen C, Lin L, Xie T, Peng L, Xu J, Yang R, Ji J, Zhao X. High-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice[J/OL]. RSC Adv,2018, 8(51):29368-29377. DOI:10.1039/c8ra05640d.
[3] Mazzon M, Mercer J. Lipid interactions during virus entry and infection[J/OL]. Cell Microbiol, 2014, 16(10):1493-1502. DOI:10.1111/cmi.12340.
[4] San-Juan-Vergara H, Sampayo-Escobar V, Reyes N,Cha B, Pacheco-Lugo L, Wong T, Peeples M E,Collins P L, Castano M E, Mohapatra S S. Cholesterolrich microdomains as docking platforms for respiratory syncytial virus in normal human bronchial epithelial cells[J/OL]. J Virol, 2012, 86(3):1832-1843. DOI:10.1128/JVI.06274-11.
[5] Brown G, Jeffree C E, McDonald T, Rixon H W,Aitken J D, Sugrue R J. Analysis of the interaction between respiratory syncytial virus and lipid-rafts in Hep2 cells during infection[J/OL]. Virology. 2004;327(2):175-185. DOI:10.1016/j.virol.2004.06.038.
[6] Veit M. Palmitoylation of virus proteins[J/OL]. Biol Cell, 2012, 104(9):493-515. DOI:10.1111/boc.201200006.
[7] Resh M D. Fatty acylation of proteins:new insights into membrane targeting of myristoylated and palmitoylated proteins[J/OL]. Biochim Biophys Acta. 1999;1451(1):1-16. DOI:10.1016/s0167-4889(99)00075-0.
[8] Yeo D S, Chan R, Brown G, Ying L, Sutejo R,Aitken J, Tan B H, Wenk M R, Sugrue R J. Evidence that selective changes in the lipid composition of raftmembranes occur during respiratory syncytial virus infection[J/OL]. Virology, 2009, 386(1):168-182.DOI:10.1016/j.virol.2008.12.017.
[9] Numata M, Kandasamy P, Nagashima Y, Fickes R,Murphy R C, Voelker D R. Phosphatidylinositol inhibits respiratory syncytial virus infection[J/OL]. J Lipid Res,2015, 56(3):578-587. DOI:10.1194/jlr.M055723.
[10]Toker A, Cantley L C. Signalling through the lipid products of phosphoinositide-3-OH kinase[J/OL].Nature. 1997;387(6634):673-676. DOI:10.1038/42648.
[11]Chen L F, Xu W B, Li Y Y, Chen N H, Luo D, Song Q Y, Tang W, Huang Z G, Li Y L, Liu Z, Li M M.Inhibitory Effect of PIK-24 on Respiratory Syncytial Virus Entry by Blocking Phosphatidylinositol-3 Kinase Signaling[J/OL]. Antimicrob Agents Chemother,2020, 64(10). DOI:10.1128/AAC.00608-20.
[12]Ludwig A, Nguyen T H, Leong D, Ravi L I, Tan B H, Sandin S, Sugrue R J. Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly[J/OL]. J Cell Sci. 2017;130(6):1037-1050. DOI:10.1242/jcs.198853.
[13]Ravi L I, Tan T J, Tan B H, Sugrue R J. Virusinduced activation of the rac1 protein at the site of respiratory syncytial virus assembly is a requirement for virus particle assembly on infected cells[J/OL].Virology, 2021, 557:86-99. DOI:10.1016/j.virol.2021.02.008.
[14]Bajimaya S, Frankl T, Hayashi T, Takimoto T.Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses[J/OL].Virology, 2017, 510:234-241. DOI:10.1016/j.virol.2017.07.024.
[15]Chang T H, Segovia J, Sabbah A, Mgbemena V, Bose S. Cholesterol-rich lipid rafts are required for release of infectious human respiratory syncytial virus particles[J/OL]. Virology, 2012, 422(2):205-213. DOI:10.1016/j.virol.2011.10.029.
[16]Kleinehr J, Wilden J J, Boergeling Y, Ludwig S,Hrincius E R. Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets[J/OL]. Viruses, 2021, 13(10).DOI:10.3390/v13102068.
[17]Martin-Vicente M, Gonzalez-Riano C, Barbas C,Jimenez-Sousa M A, Brochado-Kith O, Resino S,Martinez I. Metabolic changes during respiratory syncytial virus infection of epithelial cells[J/OL].PLoSOne, 2020, 15(3):e0230844. DOI:10.1371/journal.pone.0230844.
[18]Morris D R, Qu Y, Agrawal A, Garofalo R P, Casola A. HIF-1alpha Modulates Core Metabolism and Virus Replication in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus[J/OL]. Viruses,2020, 12(10). DOI:10.3390/v12101088.
[19]Ohol Y M, Wang Z, Kemble G, Duke G. Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses[J/OL]. PLoS One, 2015, 10(12):e0144648. DOI:10.1371/journal.pone.0144648.
[20]Hosakote Y M, Komaravelli N, Mautemps N, Liu T,Garofalo R P, Casola A. Antioxidant mimetics modulate oxidative stress and cellular signaling in airway epithelial cells infected with respiratory syncytial virus[J/OL].Am J Physiol Lung Cell Mol Physiol, 2012, 303(11):L991-1000. DOI:10.1152/ajplung.00192.2012.
[21]Walsh P, Behrens N, Carvallo Chaigneau F R,McEligot H, Agrawal K, Newman J W, Anderson M,Gershwin L J. A Randomized Placebo Controlled Trial of Ibuprofen for Respiratory Syncytial Virus Infection in a Bovine Model[J/OL]. PLoS One, 2016, 11(4):e0152913. DOI:10.1371/journal.pone.0152913.
[22]Liu T, Zaman W, Kaphalia B S, Ansari G A, Garofalo R P, Casola A. RSV-induced prostaglandin E2production occurs via cPLA2 activation:role in viral replication[J/OL]. Virology, 2005, 343(1):12-24.DOI:10.1016/j.virol.2005.08.012.
[23]Snider A J, Orr Gandy K A, Obeid L M. Sphingosine kinase:Role in regulation of bioactive sphingolipid mediators in inflammation[J/OL]. Biochimie, 2010, 92(6):707-715. DOI:10.1016/j.biochi.2010.02.008.
[24]Gonzalez-Garcia L D, Martinez-Castillo M, VargasPavia T A, Ulloa-Aguilar J M, Arevalo-Romero H,Leon-Reyes G, Helguera-Repetto A C, Garcia-Cordero J, Leon-Juarez M. Inhibition of AMP-activated protein kinase in respiratory syncytial virus infection activates lipid metabolism[J/OL]. Arch Virol, 2021, 166(4):1177-1182. DOI:10.1007/s00705-021-04974-7.
[25]Lin L, An L, Chen H, Feng L, Lu M, Liu Y, Chu C,Shan J, Xie T, Wang X, Wang S. Integrated Network Pharmacology and Lipidomics to Reveal the Inhibitory Effect of Qingfei Oral Liquid on Excessive Autophagy in RSV-Induced Lung Inflammation[J/OL]. Front Pharmacol, 2021, 12:777689. DOI:10.3389/fphar.2021.777689.
[26]Dai P, Tang Z, Qi M, Liu D, Bajinka O, Tan Y.Dispersion and utilization of lipid droplets mediates respiratory syncytial virus-induced airway hyperresponsiveness[J/OL]. Pediatr Allergy Immunol,2022, 33(1):e13651. DOI:10.1111/pai.13651.
[27]Numata M, Nagashima Y, Moore M L, Berry K Z,Chan M, Kandasamy P, Peebles R S, Jr., Murphy R C, Voelker D R. Phosphatidylglycerol provides shortterm prophylaxis against respiratory syncytial virus infection[J/OL]. J Lipid Res, 2013, 54(8):2133-2143. DOI:10.1194/jlr.M037077.
[28]Tibboel J, Reiss I, de Jongste J C, Post M.Sphingolipids in lung growth and repair[J/OL]. Chest,2014, 145(1):120-128. DOI:10.1378/chest.13-0967.
[29]Worgall T S, Veerappan A, Sung B, Kim B I, Weiner E, Bholah R, Silver R B, Jiang X C, Worgall S.Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity[J/OL]. Sci Transl Med,2013, 5(186):186ra167. DOI:10.1126/scitranslmed.3005765.
[30]Barreira E R, Precioso A R, Bousso A. Pulmonary surfactant in respiratory syncytial virus bronchiolitis:the role in pathogenesis and clinical implications[J/OL].Pediatr Pulmonol, 2011, 46(5):415-420. DOI:10.1002/ppul.21395.
[31]Churiso G, Husen G, Bulbula D, Abebe L. Immunity Cell Responses to RSV and the Role of Antiviral Inhibitors:A Systematic Review[J/OL]. Infect Drug Resist, 2022, 15:7413-7430. DOI:10.2147/IDR.S387479.
[32]Zhu L, Zhao Q, Yang T, Ding W, Zhao Y. Cellular metabolism and macrophage functional polarization[J/OL]. Int Rev Immunol, 2015, 34(1):82-100. DOI:10.3109/08830185.2014.969421.
[33]Odegaard J I, Chawla A. Alternative macrophage activation and metabolism[J/OL]. Annu Rev Pathol,2011, 6:275-297. DOI:10.1146/annurev-pathol-011110-130138.
[34]Triggiani M, Oriente A, de Crescenzo G, Rossi G,Marone G. Biochemical functions of a pool of arachidonic acid associated with triglycerides in human inflammatory cells[J/OL]. Int Arch Allergy Immunol.1995;107(1-3):261-263. DOI:10.1159/000236997.
[35]Chouinard F, Turcotte C, Guan X, Larose M C,Poirier S, Bouchard L, Provost V, Flamand L,Grandvaux N, Flamand N. 2-Arachidonoyl-glyceroland arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV[J/OL]. J Leukoc Biol, 2013, 93(2):267-276. DOI:10.1189/jlb.0412200.
[36]Ji J J, Sun Q M, Nie D Y, Wang Q, Zhang H, Qin F F, Wang Q S, Lu S F, Pang G M, Lu Z G. Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis[J/OL]. Acta Pharmacol Sin, 2021, 42(10):1630-1641. DOI:10.1038/s41401-020-00573-5.
[37]Antunes K H, Fachi J L, de Paula R, da Silva E F,Pral L P, Dos Santos A A, Dias G B M, Vargas J E,Puga R, Mayer F Q, Maito F, Zarate-Blades C R,Ajami N J, Sant'Ana M R, Candreva T, Rodrigues H G, Schmiele M, Silva Clerici M T P, Proenca-Modena J L, Vieira A T, Mackay C R, Mansur D, Caballero M T, Marzec J, Li J, Wang X, Bell D, Polack F P,Kleeberger S R, Stein R T, Vinolo M A R, de Souza A P D. Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response[J/OL]. Nat Commun, 2019,10(1):3273. DOI:10.1038/s41467-019-11152-6.
[38]Park J W, Kim H Y, Kim M G, Jeong S, Yun C H,Han S H. Short-chain Fatty Acids Inhibit Staphylococcal Lipoprotein-induced Nitric Oxide Production in Murine Macrophages[J/OL]. Immune Netw, 2019, 19(2):e9.DOI:10.4110/in.2019.19.e9.
[39]Antunes K H, Stein R T, Franceschina C, da Silva E F, de Freitas D N, Silveira J, Mocellin M, Leitao L,Fachi J L, Pral L P, Gonzalez A, Oliveira S, Duarte L, Cassao G, Goncalves J I B, Reis T M, Abbadi B L,Dornelles M, Sperotto N D M, Rigo M, Rodrigues H,Jones M, Epifanio M, Guima S, Setubal J C, Jorge T R, Mansur D S, Mayer F Q, Varela A P M, Bizarro C V, Machado P, Basso L A, Polack F P, Custovic A,Vinolo M A R, de Souza A P D. Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis[J/OL]. EBioMedicine, 2022, 77:103891.DOI:10.1016/j.ebiom.2022.103891.
[40]Ling Z, Tran K C, Teng M N. Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I[J/OL]. J Virol, 2009, 83(8):3734-3742.DOI:10.1128/JVI.02434-08.
[41]Du L N, Xie T, Xu J Y, Kang A, Di L Q, Shan J J,Wang S C. A metabolomics approach to studying the effects of Jinxin oral liquid on RSV-infected mice using UPLC/LTQ-Orbitrap mass spectrometry[J/OL]. J Ethnopharmacol, 2015, 174:25-36. DOI:10.1016/j.jep.2015.07.040.
[42]An L, Lu M, Xu W, Chen H, Feng L, Xie T, Shan J,Wang S, Lin L. Qingfei oral liquid alleviates RSVinduced lung inflammation by promoting fatty-aciddependent M1/M2 macrophage polarization via the Akt signaling pathway[J/OL]. J Ethnopharmacol, 2022,298:115637. DOI:10.1016/j.jep.2022.115637.
[43]Teoh S T, Leimanis-Laurens M L, Comstock S S,Winters J W, Vandenbosch N L, Prokop J W,Bachmann A S, Lunt S Y, Rajasekaran S. Combined plasma and urinary metabolomics uncover metabolic perturbations associated with severe respiratory syncytial viral infection and future development of asthma in infant patients[J/OL]. Metabolites, 2022, 12(2). DOI:10.3390/metabo12020178.
[44]Schoggins J W, Randall G. Lipids in innate antiviral defense[J/OL]. Cell Host Microbe, 2013, 14(4):379-385. DOI:10.1016/j.chom.2013.09.010.
[45]Gorabi A M, Kiaie N, Bianconi V, Jamialahmadi T,Al-Rasadi K, Johnston T P, Pirro M, Sahebkar A.Antiviral effects of statins[J/OL]. Prog Lipid Res,2020, 79:101054. DOI:10.1016/j.plipres.2020.101054.
[46]Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J,Wilschut J, de Haan A. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice[J/OL]. PLoS One, 2012, 7(5):e36812. DOI:10.1371/journal.pone.0036812.
[47]Park S, Lee Y, Kwon Y M, Lee Y T, Kim K H, Ko E J, Jung J H, Song M, Graham B, Prausnitz M R,Kang S M. Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge[J/OL]. PLoS One, 2018, 13(10):e0205071. DOI:10.1371/journal.pone.0205071.
[48]Gabor K A, Fessler M B. Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense[J/OL]. Curr Mol Pharmacol. 2017;10(1):27-45. DOI:10.2174/1874467209666160112123603.
[49]Fessler M B. Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism[J/OL].Curr Allergy Asthma Rep, 2015, 15(8):48. DOI:10.1007/s11882-015-0548-7.
[50]Fessler M B, Summer R S. Surfactant Lipids at the Host–Environment Interface. SensorsMetabolic,Suppressors, and Effectors of Inflammatory Lung Disease[J/OL]. American Journal of Respiratory Cell and Molecular Biology, 2016, 54(5):624-635. DOI:10.1165/rcmb.2016-0011PS.
[51]Fessler M B. A New Frontier in Immunometabolism.Cholesterol in Lung Health and Disease[J/OL]. Ann Am Thorac Soc, 2017, 14(Supplement_5):S399-S405. DOI:10.1513/AnnalsATS.201702-136AW.
基本信息:
DOI:10.13242/j.cnki.bingduxuebao.004384
中图分类号:R56
引用信息:
[1]赵天伦,秦露,刘亚丽等.呼吸道合胞病毒感染与脂质代谢相关性研究进展[J].病毒学报,2023,39(06):1713-1719.DOI:10.13242/j.cnki.bingduxuebao.004384.
基金信息:
国家新药创制专项(项目号:2017ZX09301058),题目:中药活性成分菊苣酸气雾剂的开发及其关键技术研究; 山东省自然科学基金项目(项目号:ZR2021QH111),题目:抗RSV活性成分菊苣酸的中药资源开发研究; 全国名老中医药专家传承工作室建设项目,国中医药人教函(2022)75号