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2020, 02, v.36 314-321
人乳头瘤病毒治疗性疫苗的研究进展
基金项目(Foundation): 国家自然科学基金联合基金项目重点支持项目(项目号:U1705283),题目:基于结构的人乳头瘤病毒型别交叉疫苗的分子设计和免疫机制研究~~
邮箱(Email):
DOI: 10.13242/j.cnki.bingduxuebao.003648
摘要:

人乳头瘤病毒(Human papillomavirus,HPV)感染是宫颈癌的主要致病因素,多年来人们努力通过研发HPV疫苗来控制HPV相关疾病。虽然预防性HPV疫苗的接种代表了重大的公共卫生突破,但它仅能预防HPV部分型别的感染,并不具有治疗效果,无法防止预先存在的HPV感染进展为恶性肿瘤。而以致癌蛋白E6、E7等为靶点,诱导特异性细胞毒性T细胞的HPV治疗性疫苗可以减轻甚至消除HPV相关高度病变和癌症,因此其研究具有重要意义。本文旨在阐述近年来HPV治疗性疫苗的研究进展,并为以后的治疗性疫苗研究提供指导。

Abstract:

Human papillomavirus(HPV)infection is the major cause of cervical cancer. Although application of HPV prophylactic vaccines represents a major breakthrough in public health,the vaccination only prevents some HPV types and confers no therapeutic effect. Certain data showed that HPV therapeutic vaccine candidates can induce specific cytotoxic T cells and subsequently reduce or even eliminate HPV-related lesions and cancers by using oncogenic proteins E6/E7 as targets. The vaccine research shows promising and is of great significance.This review aims to describe the research progress on HPV therapeutic vaccine in recent years and provide insight for future research on HPV therapeutic vaccines.

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基本信息:

DOI:10.13242/j.cnki.bingduxuebao.003648

中图分类号:R392

引用信息:

[1]黄诗雯,宋硕,王致萍,等.人乳头瘤病毒治疗性疫苗的研究进展[J].病毒学报,2020,36(02):314-321.DOI:10.13242/j.cnki.bingduxuebao.003648.

基金信息:

国家自然科学基金联合基金项目重点支持项目(项目号:U1705283),题目:基于结构的人乳头瘤病毒型别交叉疫苗的分子设计和免疫机制研究~~

投稿时间:

2019-09-17

投稿日期(年):

2019

终审时间:

2020-03-24

终审日期(年):

2020

审稿周期(年):

1

发布时间:

2020-02-13

出版时间:

2020-02-13

网络发布时间:

2020-02-13

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