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欧亚类禽猪流感病毒被认为是引起下次流感大流行可能性最大的动物流感病毒之一。1979年,第一次在猪群中分离到欧亚类禽猪流感病毒,该病毒随后在欧洲流行。欧亚类禽猪流感病毒从2005年起在我国猪群中广泛存在,偶尔可突破种属屏障感染人;在江苏、河北和湖南等地区已出现人感染欧亚类禽猪流感病毒,由此对公共卫生和生猪养殖业均有一定的威胁和影响。本文综述了欧亚类禽猪流感病毒的流行情况、病原学特征及其相关致病分子机制研究进展,旨在为欧亚类禽猪流感病毒的风险评估提供科学依据。
Abstract：Eurasian avian-like swine influenza viruses are considered to be the most likely candidates to cause the next influenza pandemic. They were recognized first in 1979 and became widespread in Europe. Since 2005,they have infected pigs in China,breaking through the species barrier occasionally to infect humans and,thus,posing a threat to public-health and the pig-breeding industry. To provide a scientific basis for risk assessment,we reviewed the prevalence,etiological characteristics and related pathogenic mechanism of Eurasian avian-like swine influenza viruses.
[1] Brown I H. The epidemiology and evolution of influenza viruses in pigs[J]. Vet Microbiol,2000,74:29-46.
[2] Vincent A,Awada L,Brown I,Chen H,Claes F,Dauphin G,Donis R,Culhane M,Hamilton K,Lewis N,Mumford E,Nguyen T,Parchariyanon S,Pasick J,Pavade G,Pereda A,Peiris M,Saito T,Swenson S,Van Reeth K,Webby R,Wong F,Ciacci-Zanella J.Review of influenza A virus in swine worldwide:a call for increased surveillance and research[J]. Zoonoses Public Hlth,2014,61(1):4-17.
[3] Pensaert M,Ottis K,Vandeputte J,Kaplan M M,Bachmann P A. Evidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for man[J]. B World Health Organ,1981,59(1):75-78.
[4] Jong J C D,Paccaud M F,Ronde-Verloop F M D,Huffels N H,Verwei C,Weijers T F,Bangma P J,Kregten E V,Kerckhaert J A M,Wicki F. Isolation of swine-like influenza A(H1N1)viruses from man in Switzerland and The Netherlands[J]. Annales de l'Institut Pasteur,1988,139(4):429-437.
[5] Vijaykrishna D,Smith G J D,Pybus O G,Zhu H,Bhatt S,Poon L L M,Riley S,Bahl J,Ma S K,Cheung C L,Perera R A P M,Chen H,Shortridge K F,Webby R J,Webster R G,Guan Y,Peiris J S M.Long-term evolution and transmission dynamics of swine influenza A virus[J]. Nature,2011,473(7348):519-522.
[6] Yang H,Qiao C,Tang X,Chen Y,Xin X,Chen H.Human infection from avian-like influenza A(H1N1)viruses in pigs,China[J]. Emerg Infect Dis,2012,18(7):1144-1146.
[7] Ottis K,Bachmann P A. Occurrence of Hsw1N1subtype influenza A viruses in wild ducks in Europe[J].Arch Virol,1980,63(3-4):185-190.
[8] Scholtissek C,Bürger H,Bachmann P A,Hannoun C.Genetic relatedness of hemagglutinins of the H1 subtype of influenza a viruses isolated from swine and birds[J].Virology,1983,129(2):521-523.
[9] Schultz U, Fitch W M, Ludwig S, Mandler J,Scholtissek C. Evolution of pig influenza viruses[J].Virology,1991,183(1):61-73.
[10]Ludwig S,Stitz L,Planz O,Van H,Fitch W M,Scholtissek C. European swine virus as a possible source for the next influenza pandemic?[J]. Virology,1995,212(2):555.
[11]Campitelli L,Donatelli I,Foni E,Castrucci M R,Fabiani C, Kawaoka Y, Krauss S, Webster R G.Continued evolution of H1N1 and H3N2 influenza viruses in pigs in Italy[J]. Virology,1997,232(2):310-318.
[12]Watson S J,Langat P,Reid S M,Lam T T,Cotten M,Kelly M,Van Reeth K,Qiu Y,Simon G,Bonin E, Foni E, Chiapponi C, Larsen L, Hjulsager C,Markowska-Daniel I, Urbaniak K, Durrwald R,Schlegel M, Huovilainen A, Davidson I, Dan A,Loeffen W,Edwards S,Bublot M,Vila T,Maldonado J,Valls L,Consortium E,Brown I H,Pybus O G,Kellam P. Molecular epidemiology and evolution of influenza viruses circulating within european swine between 2009 and 2013[J]. J Virol,2015,89(19):9920-9931.
[13]Nelson M I,Viboud C,Vincent A L,Culhane M R,Detmer S E,Wentworth D E,Rambaut A,Suchard M A, Holmes E C, Lemey P. Global migration of influenza A viruses in swine[J]. Nat Commun,2015,6:6696.
[14]Zhu W F,Yang S,Guo Y J,Yang L,Bai T,Yu Z J,Li X D,Li M,Guo J F,Wang D Y,Gao R B,Dong L B,Zou S M,Li Z,Wang M,Shu Y L. Imported pigs may have introduced the first classical swine influenza viruses into Mainland China[J]. Infect Genet Evol,2013,17:142-146.
[15]Guan Y,Shortridge K F,Krauss S,Li P H,Kawaoka Y,Webster R G. Emergence of avian H1N1 influenza viruses in pigs in China[J]. J Virol,1996,70(11):8041-8046.
[16]Smith G J D,Bahl J,Vijaykrishna D,Zhang J,Poon L L M,Chen H,Webster R G,Peiris J S M,Guan Y.Dating the emergence of pandemic influenza viruses[J].Proc Natl Acad Sci USA,2009,106(28):11709-11712.
[17]Liu J H,Bi Y H,Qin K,Fu G H,Yang J,Peng J S,Ma G P,Liu Q F,Pu J,Tian F L. Emergence of european avian influenza virus-like h1n1 swine influenza a viruses in China[J]. J Clin Microbiol,2009,47(8):2643-2646.
[18]Zhu H C,Zhou B P,Fan X H,Lam T T Y,Wang J,Chen A,Chen X C,Chen H L,Webster R G,Webby R, Peiris J S M, Smith D K, Guan Y. Novel reassortment of eurasian avian-like and pandemic/2009influenza viruses in swine:infectious potential for humans[J]. J Virol,2011,85(20):10432-10439.
[19]Liang H Y,Lam T T,Fan X H,Chen X C,Zeng Y,Zhou J,Duan L,Tse M,Chan C H,Li L F,Leung T Y,Yip C H,Cheung C L,Zhou B P,Smith D K,Poon L L,Peiris M,Guan Y,Zhu H C. Expansion of genotypic diversity and establishment of 2009 H1N1pandemic-origin internal genes in pigs in China[J]. J Virol,2014,88(18):10864-10874.
[20]Sun Y F,Wang X H,Li X L,Zhang L,Li H H,Lu C,Yang C L,Feng J,Han W,Ren W K,Tian X X,Tong G Z,Wen F,Li Z J,Gong X Q,Liu X M,Ruan B Y,Yan M H,Yu H. Novel triple-reassortant H1N1swine influenza viruses in pigs in Tianjin, Northern China[J]. Vet Microbiol,2016,183:85-91.
[21]Yang H L,Chen Y,Qiao C L,He X J,Zhou H,Sun Y,Yin H,Meng S S,Liu L P,Zhang Q Y,Kong H H,Gu C Y,Li C J,Bu Z G,Kawaoka Y,Chen H L.Prevalence,genetics,and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses[J].Proc Natl Acad Sci USA,2016,113:392-397.
[22]He P,Wang G J,Mo Y N,Yu Q X,Xiao X,Yang W J,Zhao W F,Guo X,Chen Q,He J Q,Liang M L,Zhu J,Ding Y B,Wei Z Z,Ouyang K,Liu F,Jian H,Huang W J,Garcia-Sastre A,Chen Y. Novel triplereassortant influenza viruses in pigs,Guangxi,China[J]. Emerg Microbes Infect,2018,7(1):85.
[23]Chen Y,Zhang J,Qiao C,Yang H,Zhang Y,Xin X,Chen H. Co-circulation of pandemic 2009 H1N1,classical swine H1N1 and avian-like swine H1N1influenza viruses in pigs in China[J]. Infect Genet Evol,2013,13:331-338.
[24]Chuvakova Z K,Rovnova Z I,Isaeva E I,Kim E V,Ignat'eva T V. 3 cases of isolating the influenza A virus with human hemagglutinin Hsw1 in 1983 in Alma-Ata[J]. Vopr virol,1985,30(5):530-6.
[25]Myers K P,Olsen C W,Setterquist S F,Capuano A W,Donham K J,Thacker E L,Merchant J A,Gray G C. Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?[J]. Clin Infect Dis,2006,42(1):14-20.
[26]Reeth K V,Nicoll A. A human case of swine influenza virus infection in Europe--implications for human health and research[J]. Euro surveillance,2009,14(7):19124.
[27]Gregory V, Bennett M, Thomas Y, Kaiser L,Wunderli W,Matter H,Hay A,Lin Y P. Human infection by a swine influenza A(H1N1)virus in Switzerland[J]. Arch Virol,2003,148(4):793-802.
[28]Adiego S B, Omenaca T M, Martinez C S, Rodrigo V P, Sanchez V P, Casas I, Pozo F, Perez B P.Human case of swine influenza A(H1N1),Aragon,Spain,November 2008[J]. Euro surveillance,2009,14(7):19120.
[29]Qi X,Cui L B,Jiao Y J,Pan Y N,Li X H,Zu R Q,Huo X,Wu B,Tang F Y,Song Y C,Zhou M H,Wang H,Cardona C J,Xing Z. Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011[J]. Arch Virol,2012,158(1):39-53.
[30]Baugh V, Figueroa J, Bosanquet J, Kemsley P,Addiman S,Turbitt D. Ongoing measles outbreak in orthodox jewish community,London,UK[J]. Emerg Infect Dis,2013,19(10):1707-1709.
[31]Zhu W F,Zhang H,Xiang X Y,Zhong L L,Yang L,Guo J F,Xie Y R,Li F C,Deng Z H,Feng H,Huang Y W,Hu S X,Xu X,Zou X H,Li X D,Bai T,Chen Y K,Li Z,Li J H,Shu Y L. Reassortant eurasian avianlike influenza a(h1n1)virus from a severely ill child,Hunan Province,China,2015[J]. Emerg Infect Dis,2016,22(11):1930-1936.
[32]Pulit-Penaloza J A,Belser J A,Tumpey T M,Maines T R. Mammalian pathogenicity and transmissibility of a reassortant Eurasian avian-like A(H1N1v)influenza virus associated with human infection in China(2015)[J]. Virology,2019,537:31-35.
[33]Xie J F,Zhang Y H,Zhao L,Xiu W Q,Chen H B,Lin Q,Weng Y W,Zheng K C. Emergence of eurasian avian-like swine influenza a(h1n1)virus from an adult case in Fujian Province,China[J]. Virol Sin,2018,33(3):282-286.
[34]Tumpey T M,Maines T R,VanHoeven N,Glaser L,Solórzano A, Pappas C, Hoeven N, Glaser L,Solórzano A,Pappas C,Cox N J,Swayne D E,Palese P,Katz J M,García-Sastre A. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission[J]. Science,2007,315(5812):655-659.
[35]Wang Z,Yang H L,Chen Y,Tao S Y,Liu L L,Kong H H,Ma S J,Meng F,Suzuki Y,Qiao C L,Chen H L. A single-amino-acid substitution at position225 in hemagglutinin alters the transmissibility of eurasian avian-like h1n1 swine influenza virus in guinea pigs[J/OL]. J Virol,2017,91(21):e00800-17.
[36]Te Velthuis A J, Fodor E. Influenza virus RNA polymerase:insights into the mechanisms of viral RNA synthesis[J]. Nat Rev Microbiol,2016,14(8):479-493.
[37]Resa-Infante P,Jorba N,Coloma R,Ortin J. The influenza virus RNA synthesis machine:advances in its structure and function[J]. Rna Biology,2011,8(2):207-215.
[38]Engelhardt O G,Matt S,Ervin F. Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II[J]. J Virol,2005,79(9):5812-5818.
[39]Gülsah G,Astrid H,Hans-Dieter K. Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus[J/OL].PLoS Pathog,2008,4(2):e11.
[40]Gabriel G,Wolff T,Palese P. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host[J]. Proc Natl Acad Sci USA,2005,102(51):18590-18595.
[41]Liu S L,Zhu W F,Feng Z M,Gao R B,Guo J F,Li X Y,Liu J,Wang D Y,Shu Y L. Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses[J]. Emerg Microbes Infect,2018,7(1):75.
[42]Cai M K,Zhong R T,Qin C X,Yu Z Q,Wen X Y,Xian J S,Chen Y J,Cai Y,Yi H Y,Gong L,Zhang G H. The R251K substitution in viral protein pb2 increases viral replication and pathogenicity of eurasian avian-like h1n1 swine influenza viruses[J]. Viruses,2020,12,52.
[43]Zhu W F,Feng Z M,Chen Y K,Yang Lei,Liu J,Li X Y,Liu S L,Zhou L J,Wei H J,Gao R B,Wang D Y,Shu Y L. Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice[J]. Emerg Microbes Infect,2019,8(1):989-999.
[44]Rossman J S,Lamb R A. Influenza virus assembly and budding[J]. Virology,2011,411(2):229-236.
[45]Nayak D P,Balogun R A,Yamada H,Zhou Z H,Barman S. Influenza virus morphogenesis and budding[J]. Virus Res,2009,143(2):147-161.
[46]Hay A J,Wolstenholme A J,Skehel J J,Smith M H.The molecular basis of the specific anti-influenza action of amantadine[J]. Embo Journal,1985,4(11):3021-3024.
[47]Torremorell M,Allerson M,Corzo C,Diaz A,Gramer M. Transmission of influenza A virus in pigs[J].Transbound Emerg Dis,2012,59 Suppl 1:68-84.
[48]Bialas K M, Desmet E A, Takimoto T. Specific residues in the 2009 H1N1 swine-origin influenza matrix protein influence virion morphology and efficiency of viral spread in vitro[J/OL]. PLoS One,2012,7(11):e50595.
[49]Campbell P J,Kyriakis C S,Marshall N,Suppiah S,Seladi-Schulman J,Danzy S,Lowen A C,Steel J.Residue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmission[J]. J Virol,2014,88(13):7569-7577.
[50]Scholtissek C,Bürger H,Kistner O,Shortridge K F.The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses[J]. Virology,1985,147(2):287-294.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004082
中图分类号:S852.65
引用信息:
[1]冯兆民,朱闻斐,舒跃龙.欧亚类禽猪流感病毒病原学研究进展[J].病毒学报,2022,38(01):205-211.DOI:10.13242/j.cnki.bingduxuebao.004082.
基金信息:
国家自然科学基金（项目号：81971941），题目：乙型流感病毒致病分子机制研究;国家自然科学基金（项目号：81961128002），题目：基于生态大数据的中国禽流感病毒进化多样性和传播动力学预测预警研究;国家自然科学基金（项目号：31761133003），题目：流感病毒流行病学和致病机制; National Natural Science Foundation of China(No. 81971941);title:Research on pathogenesis of the influenza B virus;The present work was supported by National Natural Science Foundation of China(No. 81961128002);title:Research on the evolutionary diversity and transmission dynamics of avian influenza virus in China based on ecological big data;National Natural Science Foundation of China (No.31761133003);title:Influenza virus epidemiology and pathogenesis
2020-01-08
2020
2021-12-14
2021
2020-02-01
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2021-12-16
2021-12-16
2021-12-16