2024 06 v.40 1221-1229
猴痘Ⅰ型毒株疫情流行新态势及其公共卫生风险应对策略与建议
基金项目(Foundation):
国家动物疫情监测与防治专项（项目号：125161031）,题目：牛结节性皮肤病疫情监测与防治;
国家自然基金面上项目（项目号：32473069）,题目：我国LSDV疫苗样重组流行毒株及其再重组与生物学特性研究~~
邮箱(Email):
guohuicheng@caas.cn;zhi-zhongj@163.com;
DOI:
10.13242/j.cnki.bingduxuebao.004593
中文作者单位:
中国农业科学院兰州兽医研究所动物疫病防控全国重点实验室;甘肃省病原生物学基础学科研究中心;农业农村部兽医公共卫生重点实验室;
摘要(Abstract):
猴痘（Monkeypox,Mpox）是由猴痘病毒（Mpox virus,MPXV）感染引起的一种以发热、皮疹和淋巴结肿大为特征的病毒性人兽共患病，现被WHO第二次认定为构成“全球关注的突发公共卫生事件”。2022-Mpox疫情主要由MPXV进化支Ⅱ毒株B1谱系，通过男-男性行为接触方式主要在欧美等地区的人际间流行，但已于2023年5月解除了危机状态。然而，由MPXV进化支Ⅰb毒株谱系自2023年9月前后在刚果民主共和国等非洲地区多个国家大规模暴发流行，并在非洲地区之外的瑞典、泰国等国家首次发现相应的输入病例。由于MPXV进化支Ⅰ型毒株毒力比Ⅱ型更强，致死率更高，传播方式更多，人们担心该疫情可跨国、跨洲际传播，可对全球造成巨大危害和威胁。本文重点通过猴痘Ⅰ型毒株疫情在刚果民主共和国的暴发流行态势、临床特征以及流行毒株遗传演化适应人际间传播关键点的介绍，以期为我国新一波猴痘防控和公共卫生风险提出预警和应对依据。
关键词(KeyWords):
猴痘;猴痘病毒进化支Ⅰ型毒株;流行特征;公共卫生风险;防控策略
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参考文献
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[17]Rao AK, Schrodt CA, Minhaj FS, et al. Interim clinical treatment considerations for severe manifestations of Mpox—United States, February 2023[J]. MMWR Morb Mortal Wkly Rep, 2023, 72(9):232-243. DOI:10. 15585/mmwr. mm7209a4.
[18]McQuiston JH, Luce R, Kazadi DM, et al. U. S.preparedness and response to increasing Clade I Mpox cases in the Democratic Republic of the Congo—United States, 2024[J]. MMWR Morb Mortal Wkly Rep,2024, 73(19):435-440. DOI:10. 15585/mmwr.mm7319a3.
[19]Kibungu EM, Vakaniaki EH, Kinganda-Lusamaki E, et al. Clade I–associated Mpox cases associated with sexual contact, the Democratic Republic of the Congo[J]. Emerg Infect Dis, 2024, 30(1):172-176. DOI:10. 3201/eid3001. 231164.
[20]Schwartz DA. High rates of miscarriage and stillbirth among pregnant women with Clade I Mpox(monkeypox)are confirmed during 2023–2024 DR Congo outbreak in South Kivu Province[J]. Viruses,2024, 16(7):1123. DOI:10. 3390/v16071123.
[21]WHO. WHO Disease outbreak news November 2023[EB/OL].(2023-11-06)[2024-08-27]. https：//www.who.int/emergencies/disease-outbreak-news/item/2023-DON493.
[22]Kibungu EM, Vakaniaki EH, Kinganda-Lusamaki E, et al. Clade I-associated Mpox cases associated with sexual contact, the Democratic Republic of the Congo[J].Emerg Infect Dis, 2024, 30(1):172-176. DOI:10. 3201/eid3001. 231164.
[23]Katoto PD, Muttamba W, Bahizire E, et al. Shifting transmission patterns of human Mpox in South Kivu,DR Congo[J]. Lancet InfectDis, 2024, 24(6):e354-e355. DOI:10. 1016/s1473-3099(24)00287-1.
[24]Masirika LM, Nieuwenhuijse DF, Ndishimye P, et al.Mapping the distribution and describing the first cases from an ongoing outbreak of a new strain of Mpox in South Kivu, eastern Democratic Republic of Congo between September 2023 to April 2024[EB/OL].medRxiv, 24307057. https：//doi. org/10. 1101/2024. 05. 10. 24307057.
[25]Masirika LM, Udahemuka JC, Ndishimye P, et al.Epidemiology, clinical characteristics, and transmission patterns of a novel Mpox(Monkeypox)outbreak in eastern Democratic Republic of the Congo(DRC):an observational, cross-sectional cohort study[EB/OL].medRxiv, 24303395. https：//doi. org/10. 1101/2024. 03. 05. 24303395.
[26]Okwor T, Mbala PK, Evans DH, etal. A contemporary review of Clade-specific virological differences in monkeypox viruses[J]. Clin Microbiol Infect, 2023, 29(12):1502-1507. DOI:10. 1016/j.cmi. 2023. 07. 011.
[27]Ogoina D, Damon I, Nakoune E. Clinical review of human Mpox[J]. Clin Microbiol Infect, 2023, 29(12):1493-1501. DOI:10. 1016/j. cmi. 2023. 09. 004.
[28]Agarwal P, Shukla N, Bhatia A, et al. Comparative genome analysis reveals driving forces behind Monkeypox virus evolution and sheds light on the role of ATC trinucleotide motif[J]. Virus Evol, 2024, 10(1):veae043. DOI:10. 1093/ve/veae043.
[29]Suspène R, Raymond KA, Boutin L, et al.APOBEC3F is a mutational driver of the human monkeypox virus identified in the 2022 outbreak[J]. J Infect Dis, 2023, 228(10):1421-1429. DOI:10. 1093/infdis/jiad165
[30]Ulaeto D, Agafonov A, Burchfield J, et al. New nomenclature for Mpox(monkeypox)and monkeypox virus clades[J]. Lancet Infect Dis, 2023, 23(3):273-275. DOI:10. 1016/s1473-3099(23)00055-5.
[31]McCollum AM, Nakazawa Y, Ndongala GM, et al.Human monkeypox in the Kivus, a conflict region of the Democratic Republic of the Congo[J]. Am J Trop Med Hyg, 2015, 93(4):718-721. DOI:10. 4269/ajtmh. 15-0095.
[32]Sam-Agudu NA, Martyn-Dickens C, Ewa AU. A global update of Mpox(monkeypox)in children[J].Curr Opin Pediatr, 2023, 35(2):193-200. DOI:10. 1097/mop. 0000000000001232.
[2] Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human monkeypox-a potential threat?A systematic review[J]. PLoS Negl Trop Dis, 2022,16(2):e0010141. DOI:10. 1371/journal.pntd. 0010141.
[3] CDC. 2022-2023 Mpox Outbreak Global Map[EB/OL].(2024-08-06)[2024-08-27]. https：//www. cdc.gov/poxvirus/Mpox/response/2022/world-map. html.
[4] Cevik M, Tomori O, Mbala P, et al. The 2023-2024multi-source Mpox outbreaks of clade I MPXV in subSaharan Africa:alarm bell for Africa and the world[J].IJIDReg, 2024, 12:100397. DOI:10. 1016/j.ijregi. 2024. 100397.
[5] Whitehouse ER, Bonwitt J, Hughes CM, et al. Clinical and epidemiological findings from enhanced monkeypox surveillance in Tshuapa Province, Democratic Republic of the Congo during 2011–2015[J]. J Infect Dis,2021, 223(11):1870-1878. DOI:10. 1093/infdis/jiab133.
[6] Charniga K, McCollum AM, Hughes CM, et al.Updating reproduction number estimates for Mpox in the Democratic Republic of Congo using surveillance data[J]. Am J Trop Med Hyg, 2024, 110(3):561-568.DOI:10. 4269/ajtmh. 23-0215.
[7] Vakaniaki EH, Kacita C, Kinganda-Lusamaki E, et al.Sustained human outbreak of a new MPXV Clade I lineage in eastern Democratic Republic of the Congo[J].Nat Med, 2024. DOI:10. 1038/s41591-024-03130-3.
[8] Masirika LM, Udahemuka JC, Schuele L, et al.Ongoing Mpox outbreak in Kamituga, South Kivu province, associated with monkeypox virus of a novel Clade I sub-lineage, Democratic Republic of the Congo,2024[J]. EuroSurveillance,2024, 29(11):2400106.DOI:10. 2807/1560-7917. es. 2024. 29. 11. 2400106.
[9] Masirika LM, Kumar A, Dutt M, et al. Complete genome sequencing, annotation, and mutational profiling of the novel Clade I human Mpox virus,kamituga strain[J]. J Infect Dev Ctries, 2024, 18(4):600-608. DOI:10. 3855/jidc. 20136.
[10]徐锐.非洲疾控中心宣布猴痘疫情为公共卫生紧急事件[N/OL].中国科学报，2024-8-15
[11]WHO. WHO Director-General declares Mpox outbreak a public health emergency of international concern[EB/OL].(2024-08-14)[2024-08-20]. https：//www. who.int/news/item/14-08-2024-who-director-generaldeclares-Mpox-outbreak-a-public-health-emergency-ofinternational-concern.
[12]Van Dijck C, Hoff NA, Mbala-Kingebeni P, et al.Emergence of Mpox in the post-smallpox era—a narrative review on Mpox epidemiology[J]. Clin Microbiol Infect, 2023, 29(12):1487-1492. DOI:10. 1016/j. cmi. 2023. 08. 008.
[13]Ogoina D, Izibewule JH, Ogunleye A, et al. The 2017human monkeypox outbreak in Nigeria—report of outbreak experience and response in the Niger Delta University teaching hospital, bayelsa state, Nigeria[J/OL]. PLoS One, 2019, 14(4):e0214229. DOI:10. 1371/journal. pone. 0214229.
[14]WHO. 2022–24 Mpox(monkeypox)outbreak:global trends[EB/OL].(2024-08-12)[2024-08-27]. https：//worldhealthorg. shinyapps. io/mpx_global//#2_Global_situation_update.
[15]Isidro J, Borges V, Pinto M, et al. Phylogenomic characterization and signs of microevolution in the 2022multi-country outbreak of monkeypox virus[J]. Nat Med, 2022, 28:1569-1572. DOI:10. 1038/s41591-022-01907-y.
[16]O’Tooleá，Neher RA, Ndodo N, et al. APOBEC3deaminase editing in Mpox virus as evidence for sustained human transmission since at least 2016[J].Science, 2023, 382(6670):595-600. DOI:10. 1126/science. adg8116.
[17]Rao AK, Schrodt CA, Minhaj FS, et al. Interim clinical treatment considerations for severe manifestations of Mpox—United States, February 2023[J]. MMWR Morb Mortal Wkly Rep, 2023, 72(9):232-243. DOI:10. 15585/mmwr. mm7209a4.
[18]McQuiston JH, Luce R, Kazadi DM, et al. U. S.preparedness and response to increasing Clade I Mpox cases in the Democratic Republic of the Congo—United States, 2024[J]. MMWR Morb Mortal Wkly Rep,2024, 73(19):435-440. DOI:10. 15585/mmwr.mm7319a3.
[19]Kibungu EM, Vakaniaki EH, Kinganda-Lusamaki E, et al. Clade I–associated Mpox cases associated with sexual contact, the Democratic Republic of the Congo[J]. Emerg Infect Dis, 2024, 30(1):172-176. DOI:10. 3201/eid3001. 231164.
[20]Schwartz DA. High rates of miscarriage and stillbirth among pregnant women with Clade I Mpox(monkeypox)are confirmed during 2023–2024 DR Congo outbreak in South Kivu Province[J]. Viruses,2024, 16(7):1123. DOI:10. 3390/v16071123.
[21]WHO. WHO Disease outbreak news November 2023[EB/OL].(2023-11-06)[2024-08-27]. https：//www.who.int/emergencies/disease-outbreak-news/item/2023-DON493.
[22]Kibungu EM, Vakaniaki EH, Kinganda-Lusamaki E, et al. Clade I-associated Mpox cases associated with sexual contact, the Democratic Republic of the Congo[J].Emerg Infect Dis, 2024, 30(1):172-176. DOI:10. 3201/eid3001. 231164.
[23]Katoto PD, Muttamba W, Bahizire E, et al. Shifting transmission patterns of human Mpox in South Kivu,DR Congo[J]. Lancet InfectDis, 2024, 24(6):e354-e355. DOI:10. 1016/s1473-3099(24)00287-1.
[24]Masirika LM, Nieuwenhuijse DF, Ndishimye P, et al.Mapping the distribution and describing the first cases from an ongoing outbreak of a new strain of Mpox in South Kivu, eastern Democratic Republic of Congo between September 2023 to April 2024[EB/OL].medRxiv, 24307057. https：//doi. org/10. 1101/2024. 05. 10. 24307057.
[25]Masirika LM, Udahemuka JC, Ndishimye P, et al.Epidemiology, clinical characteristics, and transmission patterns of a novel Mpox(Monkeypox)outbreak in eastern Democratic Republic of the Congo(DRC):an observational, cross-sectional cohort study[EB/OL].medRxiv, 24303395. https：//doi. org/10. 1101/2024. 03. 05. 24303395.
[26]Okwor T, Mbala PK, Evans DH, etal. A contemporary review of Clade-specific virological differences in monkeypox viruses[J]. Clin Microbiol Infect, 2023, 29(12):1502-1507. DOI:10. 1016/j.cmi. 2023. 07. 011.
[27]Ogoina D, Damon I, Nakoune E. Clinical review of human Mpox[J]. Clin Microbiol Infect, 2023, 29(12):1493-1501. DOI:10. 1016/j. cmi. 2023. 09. 004.
[28]Agarwal P, Shukla N, Bhatia A, et al. Comparative genome analysis reveals driving forces behind Monkeypox virus evolution and sheds light on the role of ATC trinucleotide motif[J]. Virus Evol, 2024, 10(1):veae043. DOI:10. 1093/ve/veae043.
[29]Suspène R, Raymond KA, Boutin L, et al.APOBEC3F is a mutational driver of the human monkeypox virus identified in the 2022 outbreak[J]. J Infect Dis, 2023, 228(10):1421-1429. DOI:10. 1093/infdis/jiad165
[30]Ulaeto D, Agafonov A, Burchfield J, et al. New nomenclature for Mpox(monkeypox)and monkeypox virus clades[J]. Lancet Infect Dis, 2023, 23(3):273-275. DOI:10. 1016/s1473-3099(23)00055-5.
[31]McCollum AM, Nakazawa Y, Ndongala GM, et al.Human monkeypox in the Kivus, a conflict region of the Democratic Republic of the Congo[J]. Am J Trop Med Hyg, 2015, 93(4):718-721. DOI:10. 4269/ajtmh. 15-0095.
[32]Sam-Agudu NA, Martyn-Dickens C, Ewa AU. A global update of Mpox(monkeypox)in children[J].Curr Opin Pediatr, 2023, 35(2):193-200. DOI:10. 1097/mop. 0000000000001232.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004593
中图分类号:R511;R181.8
引用信息:
[1]景伟,何小兵,房永祥等.猴痘Ⅰ型毒株疫情流行新态势及其公共卫生风险应对策略与建议[J].病毒学报,2024,40(06):1221-1229.DOI:10.13242/j.cnki.bingduxuebao.004593.
基金信息:
国家动物疫情监测与防治专项（项目号：125161031）,题目：牛结节性皮肤病疫情监测与防治; 国家自然基金面上项目（项目号：32473069）,题目：我国LSDV疫苗样重组流行毒株及其再重组与生物学特性研究~~
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