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2025 02 v.41 279-290
慢性乙型肝炎功能性治愈生物标志物的过去、现状与未来
基金项目(Foundation): 国家自然科学基金青年科学基金项目(项目号:3240080489),题目:HBsAg特异性BCR在慢乙肝功能性治愈中的图谱特征与预测价值; 广东省重点领域研发计划(项目号:2022B1111020002),题目:华南地区主要流行人类病毒模式小鼠资源库的建立及评估应用; 广东省区域联合基金-青年基金项目(项目号:2022A1515110483),题目:干扰素a调控肝脏M1型巨噬细胞极化清除HBsAg机制研究; 广州市重点研发计划(项目号:202206080001),题目:靶向宿主免疫和病毒cccDNA的慢性乙肝治愈的新机制新靶点新策略临床转化研究; 广州市科技计划(市院联合项目)(项目号:202201020374),题目:广州市传染病动物模型重点实验室; 广州市校(院)企联合资助专题(项目号:2023A03J0786),题目:HLA-I类HBV特异性CTL表位在慢乙肝抗病毒过程中的变化~~
邮箱(Email): xiruo0833@sina.com;gz8h_lifeng@126.com;
DOI: 10.13242/j.cnki.bingduxuebao.250006
中文作者单位:

广州医科大学附属市八医院传染病研究所;广州医科大学附属市八医院肝病中心;上海市公共卫生临床中心基础研究部;

摘要(Abstract):

我国乙肝病毒携带者人数约7500万,乙肝病毒感染是引起终末期肝病的主要原因,是我国卫生健康方面主要负担之一。实现慢乙肝功能性治愈可有效避免相关肝病发生,延长患者的生存期,目前已成为乙肝领域研究热点。相当比例慢乙肝优势人群经干扰素治疗后可实现安全停药,然而,停药判断缺少简便、可靠、易操作的生物标志物。随着乙肝新药或新药联合治疗方案不断出现,越来越多患者有望实现功能性治愈,迫切需要解决慢乙肝功能性治愈的可靠生物标志物的问题。本文综述了基于乙型肝炎病毒本身的病毒学标志物(如乙肝两对半、HBV DNA/RNA、HBcrAg、HBV cccDNA),以及宿主相关免疫学生物标志物(如乙肝病毒特异性抗体、免疫细胞等)的发展历程与各评价指标的特色,并针对目前存在的问题,提出我们的观点与展望。

关键词(KeyWords): 慢性乙型肝炎;乙型肝炎病毒;功能性治愈;病毒学标志物;免疫学标志物
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基本信息:

DOI:10.13242/j.cnki.bingduxuebao.250006

中图分类号:R512.62

引用信息:

[1]朱丽芬,周佩,蔡海奕等.慢性乙型肝炎功能性治愈生物标志物的过去、现状与未来[J].病毒学报,2025,41(02):279-290.DOI:10.13242/j.cnki.bingduxuebao.250006.

基金信息:

国家自然科学基金青年科学基金项目(项目号:3240080489),题目:HBsAg特异性BCR在慢乙肝功能性治愈中的图谱特征与预测价值; 广东省重点领域研发计划(项目号:2022B1111020002),题目:华南地区主要流行人类病毒模式小鼠资源库的建立及评估应用; 广东省区域联合基金-青年基金项目(项目号:2022A1515110483),题目:干扰素a调控肝脏M1型巨噬细胞极化清除HBsAg机制研究; 广州市重点研发计划(项目号:202206080001),题目:靶向宿主免疫和病毒cccDNA的慢性乙肝治愈的新机制新靶点新策略临床转化研究; 广州市科技计划(市院联合项目)(项目号:202201020374),题目:广州市传染病动物模型重点实验室; 广州市校(院)企联合资助专题(项目号:2023A03J0786),题目:HLA-I类HBV特异性CTL表位在慢乙肝抗病毒过程中的变化~~

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