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乙脑病毒为黄病毒科病毒，通过蚊虫叮咬而感染人畜动物，引起巨大公共卫生负担。我国自20世纪40年代即分离到乙脑病毒，此后在病毒分离、传播媒介、疫苗研发等方面开展大量研究，取得极大进展。本文在回顾我国乙脑病毒研究历史和研究现状基础上提出我国乙脑病毒研究存在的问题以及今后的研究内容等，以推动我国乙脑病毒研究进一步发展。
Abstract：Japanese encephalitis virus(JEV) is a virus belonging to the family Flaviviridae, which infects human and animals through mosquito bites, causing a huge public health burden. JEVs has been isolated in China since the 1940s. Since then, a large number of studies have been carried out in virus isolation, transmission vector, JE vaccine, and some of the research results are in the international leading level. Based on the review of the history and present of JEV research in China, this paper puts forward the shortage of research and the future on JEV research in China, so as to promote the development of JEV research in China.
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#：黄祯祥教授1934年毕业于北京协和医学院，留校任内科住院医师。1941年至1943年在美国哥伦比亚大学医学院内科任讲师，从事病毒学研究工作。1943年从美国回国担任重庆的中央卫生实验院实验医理组主任，抗日战争胜利后随该单位迁到南京政府中央卫生署工作。1947年8月任中央卫生实验院北平分院院长。北平解放后，黄教授继续在北平分院工作。北平分院于1956年与其他单位合并成立中国医学科学院，黄祯祥教授任病毒学系主任。1964年，在病毒系基础上成立中国医学科学院病毒学研究所，该研究所于2002年更名为中国疾病预防控制中心病毒病预防控制所。黄教授于1939年报道北京发生的乙脑流行（Huang,et al; Chinese Medical Journal;58:427-439;1940），详细记录了1939 年北京协和医院收治16例急性脑炎患者的流行病学特征，这是我国首次报道乙脑在人群中的流行。
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004530
中图分类号:R373
引用信息:
[1]梁国栋.中国大陆乙脑病原学研究的历史与现状[J].病毒学报,2024,40(04):671-678.DOI:10.13242/j.cnki.bingduxuebao.004530.
基金信息:
国家重点研发计划资助（项目号：2022YFC2305304）,题目：急性自然疫源性传染病病原体基因组和关键甄别位点参比数据库的建立; 国家自然科学基金重大项目（项目号：81290342）,题目：蚊虫携带人类病原体的发现与分离鉴定,分布特点,遗传进化规律及其与人类病毒的关系~~