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液-液相分离（Liquid-liquid phase separation,LLPS）是真核细胞中无膜细胞器形成的基础，这一过程促进了生物组分与化学反应在时间与空间上的精细分隔，是真核细胞生物学的一项核心特征。这些由LLPS驱动的无膜细胞器，在调控基因表达、应对环境压力、修复染色质损伤以及介导免疫反应等生物学途径中扮演着不可或缺的角色。值得注意的是，LLPS相关蛋白的功能异常与病毒感染之间存在深刻的联系，多种病毒复制的不同环节均有相分离结构的参与，且宿主在应激状态下会形成相分离结构抵抗病毒感染。本文从LLPS参与病毒感染的机制及宿主基于LLPS衍生的抗病毒策略两方面阐述相分离在病毒感染中的调控作用，深入了解相分离在病毒感染过程中发挥的作用。
Abstract：Liquid-liquid phase separation(LLPS) constitutes the basis of the formation of membraneless organelles in eukaryotic cells, facilitating the spatial and temporal segregation of biological components and chemical reactions This process is a core feature of eukaryotic cell biology. LLPS-driven membraneless organelles play indispensable roles in key biological pathways, such as the regulation of gene expression, the response to environmental stress, chromatin damage repair, and the mediation of immune responses. Notably, a profound connection exists between the dysfunction of LLPS-related proteins and viral infections. Phaseseparating structures are involved in various stages of viral replication, and host cells can form LLPS-driven granule structures to combat virus infection. This review discusses the mechanism by which LLPS participates in viral infections and the host's antiviral strategies derived from LLPS, providing a comprehensive understanding of the role LLPS plays in viral infections.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.240245
中图分类号:R511
引用信息:
[1]刘雅琪,刘茜,岑山.液-液相分离在病毒感染中的研究进展[J].病毒学报,2025,41(02):608-617.DOI:10.13242/j.cnki.bingduxuebao.240245.
基金信息:
中国医学科学院医学与健康科技创新工程（项目号：2021-I2M-1-038）,题目：应对新发突发传染病应急防控生物安全保障关键技术研究; 国家自然科学基金项目（项目号：32400139）,题目：MOV10非经典途径募集DCP2介导LINE-1 RNA脱帽机制的研究~~
2024-10-14
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2025-02-11
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2025-01-03
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2025-02-11
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