| 151 | 0 | 193 |
| 下载次数 | 被引频次 | 阅读次数 |
分析人间传染的高致病性病毒感染的动物模型应用情况，探讨人间传染的高致病性病毒在建立感染性动物模型中遇到的问题，为传染病防控科研和临床研究中动物模型选择和使用提供参考和依据。通过检索中国知网、万方数据库及PubMed数据库中人间传染的高致病性病毒感染动物模型的文献，对人间传染的高致病性病毒常用的感染性动物模型进行分析探讨。危害程度为第一类的高致病性病毒中，使用小鼠、猴及豚鼠为感染性动物模型的分别占95.83%、79.17%及62.50%；危害程度为第二类的高致病性病毒中，使用小鼠、猴及兔为感染性动物模型的分别占91.17%、55.88%及24.32%。使用实验小鼠作为感染性动物模型中，BALB/c小鼠和C57BL/6小鼠的比例分别占17.33%和13.33%。基因修饰小鼠归于其他小鼠类型，在其他类型占68.83%。使用实验猴作为感染性动物模型中，恒河猴和食蟹猴比例分别占37.18%和26.92%。相同科属的病毒使用的动物模型大致相同；其中还有16种高致病性病毒未检索到感染性动物模型的相关文章，包括类天花病毒、希普尔病毒、萨比亚病毒等。目前人间传染的高致病性病毒感染性动物模型使用最多的是小鼠，其次是猴；在使用的感染性小鼠动物模型中，BALB/c小鼠和C57BL/6小鼠的使用较多，基因修饰小鼠也被广泛使用；在使用的感染性猴动物模型中，食蟹猴及恒河猴使用最为广泛。对未检索到感染性动物模型的16种病毒，如类天花病毒、希普尔病毒、戈尔迪病毒等应提高关注，需探索建立以上病毒感染性动物模型的方法，为传染病的防控提前做好技术储备。
Abstract：This study analyzed the application of animal models for highly pathogenic human infectious viruses and discussed the challenges encountered in establishing infectious animal models. The paper aims to provide references for the use of animal models in infectious disease prevention and clinical research. The paper analyzed the published infectious animal models used in highly pathogenic human viruses through databases in CNKI, Wanfang, and PubMed. Among the infectious animal models used for the first-class highly pathogenic viruses published in the databases, the rate of use of mice, monkeys and guinea pigs was 95.83%, 79.17% and 62.50%, respectively. For the infectious animal models used in the second class of highly pathogenic viruses, the rate was 91.17% in mice, 55.88% in monkeys and 24.32% in rabbits. BALB/c and C57BL/6 mice accounted for 17.33% and 13.33% respectively when analyzing studies using infectious mouse models.Genetically modified mice accounted for 68.83% under other mouse types. In the analysis of studies using infectious monkey models, rhesus and cynomolgus monkeys accounted for 37.18% and 26.92%. Viruses within the same genus or family tended to use similar infectious animal models. In addition, we did not find relevant studies in infectious animal models for 16 highly pathogenic viruses, including Alastrim, Hepel and Sabia viruses. In conclusion, mice are the most commonly used infectious animal model in highly pathogenic human infectious viruses, followed by monkeys. Among the infectious mouse models published in the papers, the BALB/c and C57BL/6 strains are widely used, with genetically modified mice also playing an important role.Among the monkey models, the rhesus and cynomolgus monkeys are the most frequently used. More attention should be paid to the 16 viruses lacking established infectious animal models, such as Alastrim virus, Hypr virus, and Gordil viruses. Methods for establishing animal models for these viruses need to be explored in advance to prepare for effective infectious disease prevention and control.
[1]高晨，宋芹芹，宋娟，等.《人间传染的病原微生物目录》中病毒部分的解读[J].中华实验和临床病毒学杂志，2023, 37(6):578-582. DOI:10. 3760/cma. j.cn112866-20231009-00041.
[2] Clay Bavinger J, Shantha JG, Yeh S. Ebola, COVID-19, and emerging infectious disease:lessons learned and future preparedness[J]. Curr Opin Ophthalmol, 2020,31(5):416-422.DOI:10. 1097/ICU. 0000000000000683.
[3]贾帅楠，李劲涛，赵丽娇，等.环境致癌物与病毒协同致癌作用的研究进展[J].病毒学报，2018, 34(4):601-609.DOI:10. 13242/j.cnki.bingduxuebao. 003381.
[4] Brockhurst JK, Villano JS. The role of animal research in pandemic responses[J]. Comp Med, 2021, 71(5):359-368. DOI:10. 30802/AALAS-CM-21-000062.
[5] Gallardo-Romero NF, Hutson CL, Carroll D, et al.Use of live Variola virus to determine whether CAST/EiJ mice are a suitable surrogate animal model for human smallpox[J]. Virus Res, 2020, 275:197772. DOI:10. 1016/j. virusres. 2019. 197772.
[6] Moss B, Smith GL. Research with Variola virus after smallpox eradication:Development of a mouse model for Variola virus infection[J]. PLoS Pathog, 2021, 17(9):e1009911. DOI:10. 1371/journal. ppat. 1009911.
[7]汪洁英，宁博，曹莹，等.猴痘的研究进展及防控对策[J].中国人兽共患病学报，2023, 39(7):631-638.DOI:10. 3969/j. issn. 1002-2694. 2023. 00. 061.
[8] Wei ZK, Zhao YC, Wang ZD, et al. Animal models of mpox virus infection and disease[J]. Infect Med(Beijing), 2023, 2(3):153-166. DOI:10. 1016/j.imj. 2023. 05. 004.
[9] Middleton D. Hendra virus[J]. Vet Clin North Am Equine Pract, 2014, 30(3):579-589. DOI:10. 1016/j.cveq. 2014. 08. 004.
[10]de Wit E, Munster VJ. Animal models of disease shed light on Nipah virus pathogenesis and transmission[J]. J Pathol, 2015, 235(2):196-205. DOI:10. 1002/path. 4444.
[11]Wahlberg P, Saikku P, Brummer-Korvenkontio M.Tick-borne viral encephalitis in Finland. The clinical features of Kumlinge disease during 1959-1987[J]. J Intern Med, 1989, 225(3):173-177. DOI:10. 1111/j. 1365-2796. 1989. tb00059. x.
[12]Shah SZ, Jabbar B, Ahmed N, et al. Epidemiology,pathogenesis, and control of a tick-borne diseasekyasanur forest disease:current status and future directions[J]. Front Cell Infect Microbiol, 2018, 8:149. DOI:10. 3389/fcimb. 2018. 00149.
[13]Sheahan BJ, Moore M, Atkins GJ. The pathogenicity of louping ill virus for mice and lambs[J]. J Comp Pathol, 2002, 126(2-3):137-146. DOI:10. 1053/jcpa. 2001. 0533.
[14]Holbrook MR, Aronson JF, Campbell GA, et al. An animal model for the tickborne flavivirus—Omsk hemorrhagic fever virus[J]. J Infect Dis, 2005, 191(1):100-108. DOI:10. 1086/426397.
[15]Blaney JE, Speicher J, Hanson CT, et al. Evaluation of St. Louis encephalitis virus/dengue virus type 4antigenic chimeric viruses in mice and Rhesus monkeys[J]. Vaccine, 2008, 26(33):4150-4159. DOI:10. 1016/j. vaccine. 2008. 05. 075.
[16]Marques RE, Del Sarto JL, Rocha RPF, et al.Development of a model of Saint Louis encephalitis infection and disease in mice[J]. J Neuroinflammation,2017, 14(1):61. DOI:10. 1186/s12974-017-0837-2.
[17]Velay A, Paz M, Cesbron M, et al. Tick-borne encephalitis virus:molecular determinants of neuropathogenesis of an emerging pathogen[J]. Crit Rev Microbiol, 2019, 45(4):472-493. DOI:10. 1080/1040841X. 2019. 1629872.
[18]Julander JG. Animal models of yellow fever and their application in clinical research[J]. Curr Opin Virol,2016, 18:64-69.DOI:10. 1016/j.coviro. 2016. 03. 010.
[19]Gargili A, Thangamani S, Bente D. Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus[J].Front Cell Infect Microbiol, 2013, 3:39. DOI:10. 3389/fcimb. 2013. 00039.
[20]Hawman DW, Feldmann H. Crimean-Congo haemorrhagic fever virus[J]. Nat Rev Microbiol, 2023,21(7):463-477. DOI:10. 1038/s41579-023-00871-9.
[21]Weigler BJ. Biology of B virus in macaque and human hosts:a review[J]. Clin Infect Dis, 1992, 14(2):555-567. DOI:10. 1093/clinids/14. 2. 555.
[22]Phelps AL, O’Brien LM, Eastaugh LS, et al. Aerosol infection of Balb/c mice with eastern equine encephalitis virus; susceptibility and lethality[J]. Virol J, 2019, 16(1):2. DOI:10. 1186/s12985-018-1103-7.
[23]Taylor K, Kolokoltsova O, Ronca SE, et al. Live,attenuated venezuelan equine encephalitis virus vaccine(TC83)causes persistent brain infection in mice with non-functional αβ T-cells[J]. Front Microbiol, 2017,8:81. DOI:10. 3389/fmicb. 2017. 00081.
[24]Steele KE, Twenhafel NA. REVIEW PAPER:pathology of animal models of alphavirus encephalitis[J]. Vet Pathol, 2010, 47(5):790-805. DOI:10. 1177/0300985810372508.
[25]Grant A, Seregin A, Huang C, et al. Junín virus pathogenesis and virus replication[J]. Viruses, 2012, 4(10):2317-2339. DOI:10. 3390/v4102317.
[26]Kolokoltsova OA, Yun NE, Poussard AL, et al. Mice lacking alpha/beta and gamma interferon receptors are susceptible to Junin virus infection[J]. J Virol, 2010, 84(24):13063-13067. DOI:10. 1128/JVI. 01389-10.
[27]Sattler RA, Paessler S, Ly H, et al. Animal models of lassa fever[J]. Pathogens, 2020, 9(3):E197. DOI:10. 3390/pathogens9030197.
[28]Radoshitzky SR, Kuhn JH, de Kok-Mercado F, et al.Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses[J]. Expert Opin Drug Discov, 2012, 7(7):613-632. DOI:10. 1517/17460441. 2012. 687719.
[29]Günther S, Hoofd G, Charrel R, et al. Mopeia virusrelated arenavirus in natal multimammate mice,Morogoro, Tanzania[J]. Emerg Infect Dis, 2009, 15(12):2008-2012. DOI:10. 3201/eid1512. 090864.
[30]Carballal G, Calello MA, Laguens RP, et al. Tacaribe virus:a new alternative for Argentine hemorrhagic fever vaccine[J]. J Med Virol, 1987, 23(3):257-263. DOI:10. 1002/jmv. 1890230308.
[31]Furuyama W, Marzi A. Ebola virus:pathogenesis and countermeasure development[J]. Annu Rev Virol,2019, 6(1):435-458. DOI:10. 1146/annurev-virology-092818-015708.
[32]Shifflett K, Marzi A. Marburg virus pathogenesisdifferences and similarities in humans and animal models[J]. Virol J, 2019, 16(1):165. DOI:10. 1186/s12985-019-1272-z.
[33]Kenyon RH, Rippy MK, McKee KT, et al. Infection of Macaca radiata with viruses of the tick-borne encephalitis group[J]. Microb Pathog, 1992, 13(5):399-409. DOI:10. 1016/0882-4010(92)90083-z.
[34]林新武，黄素兰，张述铿.鄂木斯克出血热[J].口岸卫生控制，2008, 13(5):46-48. DOI:10. 3969/j.issn. 1008-5777. 2008. 05. 016.
[35]Terrell TG, Stookey JL, Eddy GA, et al. Pathology of Bolivian hemorrhagic fever in the Rhesus monkey[J].Am J Pathol, 1973, 73(2):477-494.
[36]Lange JV, Mitchell SW, McCormick JB, et al. Kinetic study of platelets and fibrinogen in Lassa virus-infected monkeys and early pathologic events in Mopeia virusinfected monkeys[J]. Am J Trop Med Hyg, 1985, 34(5):999-1007. DOI:10. 4269/ajtmh. 1985. 34. 999.
[37]Roy CJ, Reed DS, Wilhelmsen CL, et al. Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs[J]. Virol J, 2009, 6:170. DOI:10. 1186/1743-422X-6-170.
[38]Pushko P, Bray M, Ludwig GV, et al. Recombinant RNA replicons derived from attenuated Venezuelan equine encephalitis virus protect guinea pigs and mice from Ebola hemorrhagic fever virus[J]. Vaccine, 2000,19(1):142-153. DOI:10. 1016/s0264-410x(00)00113-4.
[39]Hall WC, Geisbert TW, Huggins JW, et al.Experimental infection of guinea pigs with Venezuelan hemorrhagic fever virus(Guanarito):a model of human disease[J]. Am J Trop Med Hyg, 1996, 55(1):81-88. DOI:10. 4269/ajtmh. 1996. 55. 81.
[40]Webb PA, Justines G, Johnson KM. Infection of wild and laboratory animals with Machupo and Latino viruses[J]. Bull World Health Organ, 1975, 52(4-6):493-499.
[41]Kim EH, Park SJ. Emerging tick-borne Dabie bandavirus:virology, epidemiology, and prevention[J]. Microorganisms, 2023, 11(9):2309. DOI:10. 3390/microorganisms11092309.
[42]Brault AC, Savage HM, Duggal NK, et al. Heartland virus epidemiology, vector association, and disease potential[J]. Viruses, 2018, 10(9):498. DOI:10. 3390/v10090498.
[43]Bosco-Lauth AM, Calvert AE, Jeffrey Root J, et al.Vertebrate host susceptibility to heartland virus[J].Emerg Infect Dis, 2016, 22(12):2070-2077. DOI:10. 3201/eid2212. 160472.
[44]Matsuno K, Orba Y, Maede-White K, et al. Animal models of emerging tick-borne phleboviruses:determining target cells in a lethal model of SFTSV infection[J]. Front Microbiol, 2017, 8:104. DOI:10. 3389/fmicb. 2017. 00104.
[45]Westover JB, Rigas JD, Van Wettere AJ, et al.Heartland virus infection in hamsters deficient in type I interferon signaling:Protracted disease course ameliorated by favipiravir[J]. Virology, 2017, 511:175-183. DOI:10. 1016/j. virol. 2017. 08. 004.
[46]Godsey MS, Savage HM, Burkhalter KL, et al.Transmission of heartland virus(Bunyaviridae:Phlebovirus)By Experimentally Infected Amblyomma americanum(Acari:Ixodidae)[J]. J Med Entomol,2016, 53(5):1226-1233. DOI:10. 1093/jme/tjw080.
[47]Clarke LL, Ruder MG, Mead D, et al. Experimental infection of white-tailed Deer(Odocoileus virginanus)with heartland virus[J]. Am J Trop Med Hyg, 2018, 98(4):1194-1196. DOI:10. 4269/ajtmh. 17-0963.
[48]Ross TM, Bhardwaj N, Bissel SJ, et al. Animal models of Rift Valley fever virus infection[J]. Virus Res, 2012, 163(2):417-423. DOI:10. 1016/j.virusres. 2011. 10. 023.
[49]Heydarabadi FH, Abdoli A, Gharibzadeh S, et al. Role of autophagy in nerve cell apoptosis in mice infected with street rabies virus[J]. Arch Virol, 2020, 165(12):2857-2867. DOI:10. 1007/s00705-020-04815-z.
[50]van Doremalen N, Munster VJ. Animal models of Middle East respiratory syndrome coronavirus infection[J]. Antiviral Res, 2015, 122:28-38. DOI:10. 1016/j. antiviral. 2015. 07. 005.
[51]Saravanan UB, Namachivayam M, Jeewon R, et al.Animal models for SARS-CoV-2 and SARS-CoV-1pathogenesis, transmission and therapeutic evaluation[J]. World J Virol, 2022, 11(1):40-56. DOI:10. 5501/wjv. v11. i1. 40.
[52]Fan C, Wu Y, Rui X, et al. Animal models for COVID-19:advances, gaps and perspectives[J].Signal Transduct Target Ther, 2022, 7(1):220. DOI:10. 1038/s41392-022-01087-8.
[53]Golden JW, Hammerbeck CD, Mucker EM, et al.Animal models for the study of rodent-borne hemorrhagic fever viruses:arenaviruses and hantaviruses[J]. Biomed Res Int, 2015, 2015:793257. DOI:10. 1155/2015/793257.
[54]Wei Z, Shimizu K, Sarii RS, et al. Pathological studies on hantaan virus-infected mice simulating severe hemorrhagic fever with renal syndrome[J]. Viruses,2022, 14(10):2247. DOI:10. 3390/v14102247.
[55]Frank JC, Song BH, Lee YM. Mice as an animal model for Japanese encephalitis virus research:mouse susceptibility, infection route, and viral pathogenesis[J]. Pathogens, 2023, 12(5):715. DOI:10. 3390/pathogens12050715.
[56]朱耐伟，谭雨豪，朱勇喆.乙型脑炎病毒感染动物模型的研究进展[J].热带医学杂志，2016, 16(11):1473-1475. DOI:10. 3969/j. issn. 1672-3619. 2016. 11. 036.
[57]de Wispelaere M, Frenkiel MP, Desprès P. A Japanese encephalitis virus genotype 5 molecular clone is highly neuropathogenic in a mouse model:impact of the structural protein region on virulence[J]. J Virol, 2015,89(11):5862-5875. DOI:10. 1128/JVI. 00358-15.
[58]Hayasaka D, Shirai K, Aoki K, et al. TNF-α acts as an immunoregulator in the mouse brain by reducing the incidence of severe disease following Japanese encephalitis virus infection[J]. PLoS One, 2013, 8(8):e71643. DOI:10. 1371/journal. pone. 0071643.
[59]Urosevic N, van Maanen M, Mansfield JP, et al.Molecular characterization of virus-specific RNA produced in the brains of flavivirus-susceptible andresistant mice after challenge with Murray Valley encephalitis virus[J]. J Gen Virol, 1997, 78(Pt 1):23-29. DOI:10. 1099/0022-1317-78-1-23.
[60]Kiyotake M, Takashima I, Hashimoto N.Pathogenicity of Negishi virus in mice characterized by age of susceptibility, routes of inoculation and growth of the virus in tissues[J]. Jpn J Vet Res, 1983, 31(1):7-13.
[61]Mlera L, Meade-White K, Saturday G, et al. Modeling Powassan virus infection in Peromyscus leucopus, a natural host[J]. PLoS Negl Trop Dis, 2017, 11(1):e0005346. DOI:10. 1371/journal. pntd. 0005346.
[62]Saivish MV, Gomes da Costa V, de Lima Menezes G,et al. Rocio virus:an updated view on an elusive flavivirus[J]. Viruses, 2021, 13(11):2293. DOI:10. 3390/v13112293.
[63]Graham JB, Swarts JL, Lund JM. A mouse model of west Nile virus infection[J]. Curr Protoc Mouse Biol,2017, 7(4):221-235. DOI:10. 1002/cpmo. 33.
[64]Byas AD, Ebel GD. Comparative pathology of west Nile virus in humans and non-human animals[J].Pathogens, 2020, 9(1):48. DOI:10. 3390/pathogens9010048.
[65]Atkinson B, Marston DA, Ellis RJ, et al. Complete genomic sequence of issyk-kul virus[J]. Genome Announc, 2015, 3(4):e00662-15. DOI:10. 1128/genomeA. 00662-15.
[66]Sugimoto S, Suda Y, Nagata N, et al. Characterization of Keterah orthonairovirus and evaluation of therapeutic candidates against Keterah orthonairovirus infectious disease[J]. Ticks Tick Borne Dis, 2022, 13(1):101834. DOI:10. 1016/j. ttbdis. 2021. 101834.
[67]Maze EA, Chrun T, Booth G, et al. Generation and characterisation of monoclonal antibodies against Nairobi sheep disease virus nucleoprotein[J]. Viruses, 2023, 15(9):1876. DOI:10. 3390/v15091876.
[68]Moming A, Shen S, Fang Y, et al. Evidence of human exposure to tamdy virus, northwest China[J]. Emerg Infect Dis, 2021, 27(12):3166-3170. DOI:10. 3201/eid2712. 203532.
[69]Hatziioannou T, Evans DT. Animal models for HIV/AIDS research[J]. Nat Rev Microbiol, 2012, 10(12):852-867. DOI:10. 1038/nrmicro2911.
[70]Simard MC, Chrobak P, Kay DG, et al. Expression of Simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease[J].J Virol, 2002, 76(8):3981-3995. DOI:10. 1128/jvi. 76. 8. 3981-3995. 2002.
[71]Couderc T, Chrétien F, Schilte C, et al. A mouse model for chikungunya:young age and inefficient type-I interferon signaling are risk factors for severe disease[J]. PLoS Pathog, 2008, 4(2):e29. DOI:10. 1371/journal. ppat. 0040029.
[72]Henderson BE, Chappell WA, Johnston JG, et al.Experimental infection of horses with three strains of Venezuelan equine encephalomyelitis virus. I. Clinical and virological studies[J]. Am J Epidemiol, 1971, 93(3):194-205. DOI:10. 1093/oxfordjournals. aje.a121246.
[73]?ikutováS, Do?kal P, StrakováP, et al. First record of mosquito-borne kyzylagach virus in central Europe[J]. Viruses, 2020, 12(12):1445. DOI:10. 3390/v12121445.
[74]Coimbra TLM, Santos CLS, Suzuki A, et al. Mayaro virus:imported cases of human infection in S?o Paulo State, Brazil[J]. Rev Inst Med Trop Sao Paulo, 2007,49(4):221-224. DOI:10. 1590/s0036-46652007000400005.
[75]Rosa RB, de Castro EF, de Oliveira Santos D, et al.Mouse models of mayaro virus[J]. Viruses, 2023, 15(9):1803. DOI:10. 3390/v15091803.
[76]O’Brien LM, Goodchild SA, Phillpotts RJ, et al. A humanised murine monoclonal antibody protects mice from Venezuelan equine encephalitis virus, Everglades virus and Mucambo virus when administered up to 48 h after airborne challenge[J]. Virology, 2012, 426(2):100-105. DOI:10. 1016/j. virol. 2012. 01. 038.
[77]Moolla N, Viljoen N, Patharoo V, et al. Nearcomplete genome sequence of ndumu virus from Garissa, Kenya, 1997[J]. Microbiol Resour Announc,2021, 10(34):e0055121. DOI:10. 1128/MRA. 00551-21.
[78]von Herrath M, Whitton JL. Animal models using lymphocytic choriomeningitis virus[J]. Curr Protoc Immunol, 2001, Chapter 19:Unit19. 10. DOI:10. 1002/0471142735. im1910s36.
[79]Horie H, Koike S, Kurata T, et al. Transgenic mice carrying the human poliovirus receptor:new animal models for study of poliovirus neurovirulence[J]. J Virol, 1994, 68(2):681-688. DOI:10. 1128/JVI. 68. 2. 681-688. 1994.
[80]Thimme R, Frese M, Kochs G, et al. Mx1 but not MxA confers resistance against tick-borne Dhori virus in mice[J]. Virology, 1995, 211(1):296-301. DOI:10. 1006/viro. 1995. 1404.
[81]Gong W, Huang K, Zhang Y, et al. Transcriptome profiles of highly pathogenic pure avian H7N9 virusinfected lungs of BALB/c mice[J]. Front Vet Sci,2020, 7:603584. DOI:10. 3389/fvets. 2020. 603584.
[82]Lindsey HS, Calisher CH, Mathews JH. Serum dilution neutralization test for California group virus identification and serology[J]. J Clin Microbiol, 1976, 4(6):503-510. DOI:10. 1128/jcm. 4. 6. 503-510. 1976.
[83]Olson LC, Sithisarn P, Djinawi NK. Role of macrophages in Wesselsbron and Germiston virus infections of mice[J]. J Infect Dis, 1975, 131(2):119-128. DOI:10. 1093/infdis/131. 2. 119.
[84]Travassos da Rosa JF, de Souza WM, Pinheiro FP, et al. Oropouche virus:clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus[J].Am J Trop Med Hyg, 2017, 96(5):1019-1030. DOI:10. 4269/ajtmh. 16-0672.
[85]Groen J, Gerding M, Koeman JP, et al. A macaque model for hantavirus infection[J]. J Infect Dis, 1995,172(1):38-44. DOI:10. 1093/infdis/172. 1. 38.
[86]Hooper JW, Custer DM, Thompson E, et al. DNA vaccination with the Hantaan virus M gene protects Hamsters against three of four HFRS hantaviruses and elicits a high-titer neutralizing antibody response in Rhesus monkeys[J]. J Virol, 2001, 75(18):8469-8477. DOI:10. 1128/jvi. 75. 18. 8469-8477. 2001.
[87]Perley CC, Brocato RL, Kwilas SA, et al. Three asymptomatic animal infection models of hemorrhagic fever with renal syndrome caused by hantaviruses[J].PLoS One, 2019, 14(5):e0216700. DOI:10. 1371/journal. pone. 0216700.
[88]Myint KSA, Kipar A, Jarman RG, et al.Neuropathogenesis of Japanese encephalitis in a primate model[J]. PLoS Negl Trop Dis, 2014, 8(8):e2980.DOI:10. 1371/journal. pntd. 0002980.
[89]Ebel GD. Update on Powassan virus:emergence of a North American tick-borne flavivirus[J]. Annu Rev Entomol, 2010, 55:95-110. DOI:10. 1146/annurevento-112408-085446.
[90]Saxena V, Bolling BG, Wang T. West Nile virus[J].Clin Lab Med, 2017, 37(2):243-252. DOI:10. 1016/j. cll. 2017. 01. 001.
[91]Teleshova N, Derby N, Martinelli E, et al. Simian immunodeficiency virus interactions with macaque dendritic cells[J]. Adv Exp Med Biol, 2013, 762:155-181. DOI:10. 1007/978-1-4614-4433-6_6.
[92]Labadie K, Larcher T, Joubert C, et al. Chikungunya disease in nonhuman Primates involves long-term viral persistence in macrophages[J]. J Clin Invest, 2010, 120(3):894-906. DOI:10. 1172/JCI40104.
[93]Burkett-Cadena ND, Fish D, Weaver S, et al.Everglades virus:an underrecognized disease-causing subtype of Venezuelan equine encephalitis virus endemic to Florida, USA[J]. J Med Entomol, 2023, 60(6):1149-1164. DOI:10. 1093/jme/tjad070.
[94]Weber WC, Labriola CS, Kreklywich CN, et al.Mayaro virus pathogenesis and immunity in Rhesus macaques[J]. PLoS Negl Trop Dis, 2023, 17(11):e0011742. DOI:10. 1371/journal. pntd. 0011742.
[95]Zapata JC, David Pauza C, Djavani MM, et al.Lymphocytic choriomeningitis virus(LCMV)infection of macaques:a model for Lassa fever[J]. Antiviral Res, 2011, 92(2):125-138. DOI:10. 1016/j.antiviral. 2011. 07. 015.
[96]Crotty S, Lohman BL, LüFX, et al. Mucosal immunization of Cynomolgus macaques with two serotypes of live poliovirus vectors expressing Simian immunodeficiency virus antigens:stimulation of humoral, mucosal, and cellular immunity[J]. J Virol,1999, 73(11):9485-9495. DOI:10. 1128/JVI. 73. 11. 9485-9495. 1999.
[97]Suguitan AL, Matsuoka Y, Lau YF, et al. The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004(H5N1)avian influenza virus acts as a virulence factor in a host-specific manner in mammals[J]. J Virol, 2012, 86(5):2706-2714. DOI:10. 1128/JVI. 05546-11.
[98]de Wit E, Rasmussen AL, Feldmann F, et al.Influenza virus A/Anhui/1/2013(H7N9)replicates efficiently in the upper and lower respiratory tracts of Cynomolgus macaques[J]. mBio, 2014, 5(4):e01331-14. DOI:10. 1128/mBio. 01331-14.
[99]Schwartz A, Allen WP. Experimental infection of monkeys with bunyamwera and Germiston viruses[J].Infect Immun, 1970, 2(6):762-766. DOI:10. 1128/iai. 2. 6. 762-766. 1970.
[100]Kane Y, Wong G, Gao GF. Animal models, zoonotic reservoirs, and cross-species transmission of emerging human-infecting coronaviruses[J]. Annu Rev Anim Biosci, 2023, 11:1-31. DOI:10. 1146/annurev-animal-020420-025011.
[101]解燕香，杭长寿.汉坦病毒与自然宿主动物共进化及实验动物模型的研究进展[J].中华实验和临床病毒学杂志，2000, 14(2):199. DOI:10. 3760/cma. j.issn. 1003-9279. 2000. 02. 044.
[102]Suen WW, Uddin MJ, Wang W, et al. Experimental west Nile virus infection in rabbits:an alternative model for studying induction of disease and virus control[J].Pathogens, 2015, 4(3):529-558. DOI:10. 3390/pathogens4030529.
[103]王芊芊，刘冲，傅军，等.基因修饰小鼠实验室生物安全管理体系建设[J].实验室研究与探索，2023, 42(6):144-149. DOI:10. 19927/j. cnki.syyt. 2023. 06. 029.
[104]Liu G, Lin Q, Jin S, et al. The CRISPR-Cas toolbox and gene editing technologies[J]. Mol Cell, 2022, 82(2):333-347. DOI:10. 1016/j. molcel. 2021. 12. 002.
[105]Mallah SI, Ghorab OK, Al-Salmi S, et al. COVID-19:breaking down a global health crisis[J]. Ann Clin Microbiol Antimicrob, 2021, 20(1):35. DOI:10. 1186/s12941-021-00438-7.
[106]Friedman H, Ator N, Haigwood N, et al. The critical role of nonhuman Primates in medical research[J].Pathog Immun, 2017, 2(3):352-365. DOI:10. 20411/pai. v2i3. 186.
[107]周小青，唐成程，邹庆剑. SARS-CoV-2易感实验动物研究进展[J].中国比较医学杂志，2021, 31(2):128-134.DOI:10. 3969/j.issn.1671-7856. 2021. 02. 020.
[108]《实验动物与比较医学》编辑委员会，张俊彦.动物实验与比较医学研究论文出版规范清单（2024年版）[J].实验动物与比较医学，2024, 44(5):577-582. DOI:10. 12300/j. issn. 1674-5817. 2024. 149
[109]梁冰岩，李倩倩，刘晓娟，等.发热伴血小板减少综合征布尼亚病毒疫苗的研究进展[J].病毒学报，2024,40(06):1462-1475. DOI:10. 13242/j. cnki.bingduxuebao. 004599.
[110]de Vries RBM, Buma P, Leenaars M, et al. Reducing the number of laboratory animals used in tissue engineering research by restricting the variety of animal models. Articular cartilage tissue engineering as a case study[J]. Tissue Eng Part B Rev, 2012, 18(6):427-435. DOI:10. 1089/ten. TEB. 2012. 0059.
[111] McCarthy KR, Rennick LJ, Nambulli S, et al.Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape[J]. Science, 2021,371(6534):1139-1142. DOI:10. 1126/science.abf6950.
[112]陆皖行，卢凯迪，苟洪伟，等.中国人类病毒传染病的研究进展及可视化分析[J].病毒学报，2021, 37(4):941-949.DOI:10. 13242/j.cnki.bingduxuebao. 003942.
[113]Qi F, Qin C. Characteristics of animal models for COVID-19[J]. Animal Model Exp Med, 2022, 5(5):401-409. DOI:10. 1002/ame2. 12278.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.240275
中图分类号:R373.1
引用信息:
[1]卢子薇,陈晚月,徐雪芳,等.人间传染的高致病性病毒感染动物模型在传染病防控中的应用研究探讨[J].病毒学报,2025,41(02):488-499.DOI:10.13242/j.cnki.bingduxuebao.240275.
基金信息:
国家重点研发计划项目：（项目号：2022YFC2304301）,题目：呼吸道疾病吸入和透皮剂型疫苗的研发及安全性和有效性评价;国家重点研发计划项目（项目号：2024YFF0728803）,题目：实验动物生物安全风险评估与控制关键技术研究~~
2024-11-18
2024
2025-01-02
2025-04-03
2025
1
2025-03-06
2025-03-06
2025-03-06