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2013年春季,我国首次出现人感染H7N9亚型禽流感疫情,随后H7N9禽流感病毒相继引发了五波流行,在病人中导致较多的重症感染,死亡率接近40%,成为近来的关注热点之一。本文对H7N9亚型禽流感病毒感染的T细胞免疫特征进行了系统综述,尤其是对H7N9禽流感患者在感染急性期及康复后的T细胞免疫特征、健康人群对H7N9的预存T细胞免疫、以及H7N9禽流感病毒与季节性流感病毒的交叉T细胞免疫特点等方面相关研究进展进行了总结。为了解禽流感病毒的T细胞免疫特征和研发新型流感疫苗提供科学参考。
Abstract：In the spring of 2013,the first human infection with avian influenza A(H7N9)virus occurred in China's mainland.H7N9 subsequently caused five epidemic waves subsequently and led thousands of infections.Most of the infections developed severe clinical symptoms and the mortality rate was close to 40%.Now,H7N9 has become a major public health concern.This manuscript systematically reviews the characteristics of H7N9-specific T-cell immunity,especially the T-cell immune characteristics of H7N9 infections in the acute phase and post-infection,the pre-existing T-cell immunity,and the cross-reactivities of T-cell immunity against H7N9 and seasonal influenza viruses.This review may provide a scientific basis for understanding T-cell immune characteristics of avian influenza virus and for vaccine development for newly emerging influenza viruses.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.003472
中图分类号:R392
引用信息:
[1]赵敏,舒刘梅,高福,等.H7N9亚型禽流感病毒的T细胞免疫研究[J].病毒学报,2018,34(06):911-919.DOI:10.13242/j.cnki.bingduxuebao.003472.
基金信息:
国家自然科学基金优秀青年科学基金项目(项目号:81822040),题目:病毒感染的特异T细胞免疫;国家自然科学基金面上项目(项目号:81373141),题目:不同HLA超级型人群对流感病毒的交叉CD8+T细胞反应及机制研究~~
2018-11-13
2018
2020-03-25
2020
2
2018-11-26
2018-11-26
2018-11-26