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鸭坦布苏病毒病是一种由鸭坦布苏病毒（Duck tembusu virus, DTMUV）引起雏鸭出现神经症状、种鸭生产性能降低、蛋鸭产蛋性能大幅下降的传染性疾病。DTMUV编码3种结构蛋白（C, E, prM），其中E蛋白作为DTMUV重要的免疫原性蛋白，其各结构域的氨基酸位点突变可对病毒粒子的致病性产生不同影响。本文总结了目前关于DTMUV E蛋白的研究进展，包括结构特点和关键毒力位点分析、其在病毒入侵细胞过程的功能与诱导细胞凋亡等的最新研究、以及蛋白抗原表位的最新发现。为进一步探究DTMUV E蛋白的致病机理奠定理论基础。
Abstract：Duck Tembusu disease is a viral infection in ducks caused by the Duck Tembusu virus(DTMUV).This highly contagious pathogen induces various clinical symptoms in ducks, including neurological signs in young ducklings and significant decline in egg production in both egg-laying and breeder ducks. The E protein, a crucial component of DTMUV, plays a pivotal role in triggering immune responses of the host, by activating both the innate and adaptive immune systems. This paper aims to provide a comprehensive overview of the advancements and challenges associated with the E protein of DTMUV, encompassing a thorough analysis of its structural components, particularly the three-domain configuration.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004431
中图分类号:S858.32
引用信息:
[1]陆泳锟,魏无缺,刘梦凡,等.鸭坦布苏病毒E蛋白结构与功能的研究进展[J].病毒学报,2023,39(06):1794-1803.DOI:10.13242/j.cnki.bingduxuebao.004431.
基金信息:
广东省普通高校科研项目（项目号：2020ZDZX1004）,题目：广东省重要新发水禽疫病防控共性关键技术集成与应用研究; 广东省乡村振兴战略专项,题目：广东省水禽产业技术体系创新团队~~
2023-06-03
2023
2023-08-03
2023-12-28
2023
1
2023-11-23
2023-11-23
2023-11-23