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单纯疱疹病毒(Herpes simplex virus,HSV)包括1型和2型,属于人类疱疹病毒家族的α亚族,也是人类感染最常见的病原体之一,感染可导致多种疱疹性疾病,包括疱疹性眼炎及可引起失明的疱疹性角膜炎。HSV的致病机制与病毒和宿主天然免疫系统的相互作用密切相关,涉及到病毒逃逸干扰素反应,核转录因子κB(Nuclear factorκB,NF-κB)信号通路以及病毒与免疫细胞相互作用等多个环节。本文就近年来单纯疱疹病毒与天然免疫系统的相互作用的研究进展进行综述。
Abstract：Herpes simplex virus(HSV)type 1 and type 2 are α-herpesviruses of the Herpesviridae family,representing one of the most frequently encountered infections in humans. Its infection can cause a variety of herpetic diseases,including herpetic ophthalmia and herpetic keratitis. Pathogenesis of HSV is closely related to a panel of host innate immune responses,such as escape of interferon response,suppression of nuclear factor κB(NF-κB)signaling pathway,and interactions between virus and innate immune cells. This review focuses on the research progress on interactions between HSV and host innate immunity.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.003623
中图分类号:R373
引用信息:
[1]牟唐维,李琦涵.单纯疱疹病毒与天然免疫系统的相互作用的研究进展[J].病毒学报,2020,36(01):124-129.DOI:10.13242/j.cnki.bingduxuebao.003623.
基金信息:
国家自然科学基金面上项目(项目号：31670173)，题目：基于衣被蛋白UL7突变体分析的HSV1染色质化基因组DNA重聚/解构过程与转录调控的机理研究; 中国医学科学院医学与健康科技创新工程项目(项目号：2016-12M-1-019)，题目：创新型疫苗研究~~
2019-03-06
2019
2019-03-19
2020-01-31
2020
1
2019-12-20
2019-12-20
2019-12-20