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传染性法氏囊病病毒(Infectious bursal disease virus,IBDV)是双股双节段RNA病毒科的主要代表,其主要侵害鸡的中枢免疫器官法氏囊,引起的传染性法氏囊病(Infectious bursal disease,IBD)是危害养禽业健康发展的重要免疫抑制病。IBDV反向遗传技术诞生的近20年来,病毒拯救技术不断完善,病毒基因功能研究更为深入,而且基于此的新型疫苗的研究也有较大进展。本实验室在该领域也做了比较系统和深入的工作。本综述对IBDV致病机制和防控研究具有重要启示意义。
Abstract：Infectious bursal disease virus(IBDV)is an important member of the Birnaviridae family.IBDV mainly targets the bursa of Fabricius,the central immune organ of chicken,resulting in chicken infectious bursal disease(IBD).IBD represents one of the great challenges for ongoing development of the poultry industry.Reverse genetics for IBDV emerged over twenty years ago.Since then,the technologies behind virus rescue have continually improved leading to a deep understanding of IBDV gene function and tailored vaccine development.Our lab has also been instrumental in the field of IBDV research.Here we review studies on the pathogenic mechanism and the effective prevention and control of IBD.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.002704
中图分类号:S852.65
引用信息:
[1]祁小乐,王永强,高立,等.传染性法氏囊病病毒反向遗传技术发展及其应用[J].病毒学报,2015,31(03):326-331.DOI:10.13242/j.cnki.bingduxuebao.002704.
基金信息:
国家自然科学基金(31430087,30901083); 国家973项目(2005CB523202); 国家现代农业产业技术体系建设专项基金(nycytx-42-G3-01)资助
2015-05-29
2015-05-29
2015-05-29