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本研究利用国家疾病监测信息管理系统，对2023年福建省急性出血性结膜炎（Acute hemorrhagic conjunctivitis,AHC）的暴发进行了描述性流行病学分析，并采集40份AHC患者眼结膜拭子进行病原学鉴定和基因进化分析。结果显示，福建省2023年AHC报告病例数6024例，发病率14.38/10万。5-14岁的发病儿童占发病总数的59.8%，学生、农民和幼托儿童为主要发病人群占比84.7%。40份拭子分离到26株柯萨奇病毒A组24型变异株（Coxsackievirus A24 variant,CVA24v）。基于3C和VP1区域的基因进化树表明福建26株CVA24v属于GⅣ基因型。3株福建CVA24v的全基因组序列结果显示其在5’UTR区和3C区与EV-C96存在重组。
Abstract：This study employed descriptive epidemiological analysis of acute hemorrhagic conjunctivitis(AHC) outbreaks in Fujian province, China in 2023 utilizing data from the National Disease Surveillance Information Management System(NDSIMS). Forty conjunctival swab samples from AHC patients were collected for pathogen identification and phylogenetic analysis. A total of 6,024 AHC cases were reported in Fujian province, China in 2023, yielding an incidence rate of 14.38/100,000. Children aged 5-14 accounted for 59.8% of the cases, with students, farmers, and children in early childhood care forming the primary affected groups, accounting for 84.7%. From the 40 swab samples, 26 strains of Coxsackievirus A group 24 variant(CVA24v) were isolated. Phylogenetic analysis based on the 3C and VP1 regions revealed that the 26 Fujian CVA24v strains belonged to the genotype G Ⅳ. Whole-genome sequences of three Fujian CVA24v strains indicated recombination with EV-C96 in the 5' untranslated region(UTR) and 3C region.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.240312
中图分类号:R777.31
引用信息:
[1]周蕾,朱颖,冀天娇等.2023年福建省急性出血性结膜炎病原体鉴定及基因进化分析[J].病毒学报,2025,41(02):301-309.DOI:10.13242/j.cnki.bingduxuebao.240312.
基金信息:
国家重点研发计划（项目号：2021YFF0703801）,题目：微生物科学数据整合标准及共享服务平台建设~~