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绵羊肺腺瘤病毒（Jaagsiekte sheep retrovirus,JSRV）是绵羊肺腺瘤（Ovine pulmonary adenomatosis,OPA）的病原，属于反转录病毒科，正反转录病毒亚科，β反转录病毒属，作为致癌性反转录病毒可引起绵羊发生不可逆的慢性传染性肺肿瘤疾病。JSRV的癌基因env所编码的囊膜蛋白（Envelope,Env）诱导多种类型的细胞发生恶性转化及体内肿瘤生成。OPA常被视为人鳞屑样生长型肺腺癌（Lepidic predominant adenocarcinoma,LPA）研究的理想模型。本文针对JSRV相关致病机制的最新热点研究展开综述。
Abstract：Jaagsiekte sheep retrovirus(JSRV) is the pathogen of ovine pulmonary adenocarcinoma(OPA). It belongs to the family retroviridae, subfamily orthoretroviridae and genus β-retrovirus. As an oncogenic retrovirus, it can cause irreversible chronic infectious lung tumor disease in sheep. The envelope protein(Env) encoded by the oncogene env of JSRV induces malignant transformation of various cell types and tumorigenesis in vivo. OPA is regarded as an ideal model for the study of human lepidic predominant adenocarcinoma(LPA).This article reviews the latest research focus on the pathogenic mechanism of JSRV.
[1] York DF, Querat G. A history of ovine pulmonary adenocarcinoma(jaagsiekte)and experiments leading to the deduction of the JSRV nucleotide sequence[J]. Curr Top Microbiol Immunol, 2003, 275:1-23. DOI:10. 1007/978-3-642-55638-8_1.
[2]段续接，杜晓悦，张培，等.内蒙古包头市1例绵羊肺腺瘤病的诊断与病毒env基因分析[J].内蒙古农业大学学报（自然科学版），2022, 43(5):16-22. DOI:10. 16853/j. cnki. 1009-3575. 2022. 05. 002.
[3] Zhang L, Yang H, Duan X, et al. Modulation of autophagy affected tumorigenesis induced by the envelope glycoprotein of JSRV[J]. Virology, 2024,594:110059. DOI:10. 1016/j. virol. 2024. 110059.
[4] Ortega J, Corpa JM, Castillo D, et al. Pathological spectrum of ovine pulmonary adenocarcinoma in small ruminants:a focus on the mixed form[J]. Animals(Basel), 2023, 13(18):2828. DOI:10. 3390/ani13182828.
[5]梁浚哲，段续接，杜晓悦，等.自然感染绵羊肺腺瘤病毒羊肺组织线粒体自噬分子表达分析[J].中国农业大学学报，2024, 29(8):147-156. DOI:10. 11841/j.issn. 1007-4333. 2024. 08. 12.
[6]杨惠，刘淑英.利用JSRV构建啮齿动物LPA模型研究进展[J].中国农业大学学报，2019, 24(11):98-105. DOI:10. 11841/j. issn. 1007-4333. 2019. 11. 11.
[7] Palmarini M, Hallwirth C, York D, et al. Molecular cloning and functional analysis of three type D endogenous retroviruses of sheep reveal a different cell tropism from that of the highly related exogenous jaagsiekte sheep retrovirus[J]. J Virol, 2000, 74(17):8065-8076. DOI:10. 1128/jvi. 74. 17. 8065-8076. 2000.
[8] DeMartini JC, Bishop JV, Allen TE, et al. Jaagsiekte sheep retrovirus proviral clone JSRV(JS7), derived from the JS7 lung tumor cell line, induces ovine pulmonary carcinoma and is integrated into the surfactant protein A gene[J]. J Virol, 2001, 75(9):4239-4246.DOI:10. 1128/jvi. 75. 9. 4239-4246. 2001.
[9] Griffiths DJ, Martineau HM, Cousens C. Pathology and pathogenesis of ovine pulmonary adenocarcinoma[J]. J Comp Pathol, 2010, 142(4):260-283. DOI:10. 1016/j. jcpa. 2009. 12. 013.
[10]Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al.Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus[J]. Proc Natl Acad Sci USA, 2003, 100(8):4580-4585. DOI:10. 1073/pnas. 0837136100.
[11]Leroux C, Girard N, Cottin V, et al. Jaagsiekte Sheep Retrovirus(JSRV):from virus to lung cancer in sheep[J]. Vet Res, 2007, 38(2):211-228. DOI:10. 1051/vetres:2006060.
[12]Herring AJ, Sharp JM, Scott FMM, et al. Further evidence for a retrovirus as the aetiological agent of sheep pulmonary adenomatosis(jaagsiekte)[J]. Vet Microbiol, 1983, 8(3):237-249. DOI:10. 1016/0378-1135(83)90076-7.
[13]Martin WB, Scott FM, Sharp JM, et al. Experimental production of sheep pulmonary adenomatosis(Jaagsiekte)[J]. Nature, 1976, 264(5582):183-185.DOI:10. 1038/264183a0.
[14]York DF, Vigne R, Verwoerd DW, et al. Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats[J]. J Virol, 1992, 66(8):4930-4939. DOI:10. 1128/jvi. 66. 8. 4930-4939. 1992.
[15]Palmarini M, Sharp JM, Lee C, et al. In vitro infection of ovine cell lines by Jaagsiekte sheep retrovirus[J]. J Virol, 1999, 73(12):10070-10078. DOI:10. 1128/jvi. 73. 12. 10070-10078. 1999.
[16]Palmarini M, Sharp JM, de las Heras M, et al.Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer in sheep[J]. J Virol,1999, 73(8):6964-6972. DOI:10. 1128/jvi. 73. 8. 6964-6972. 1999.
[17]Karagianni AE, Vasoya D, Finlayson J, et al.Transcriptional response of ovine lung to infection with jaagsiekte sheep retrovirus[J]. J Virol, 2019, 93(21):e00876-e00819. DOI:10. 1128/jvi. 00876-19.
[18]Miller AD, De las Heras M, Yu J, et al. Evidence against a role for jaagsiekte sheep retrovirus in human lung cancer[J]. Retrovirology, 2017, 14(1):3. DOI:10. 1186/s12977-017-0329-6.
[19]Palmarini M, Murgia C, Fan H. Spliced and prematurely polyadenylated jaagsiekte sheep retrovirusspecific RNAs from infected or transfected cells[J].Virology, 2002, 294(1):180-188. DOI:10. 1006/viro. 2001. 1323.
[20]Maeda N, Palmarini M, Murgia C, et al. Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA[J]. Proc Natl Acad Sci USA, 2001, 98(8):4449-4454. DOI:10. 1073/pnas. 071547598.
[21]Maeda N, Fu W, Ortin A, et al. Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines[J]. J Virol,2005, 79(7):4440-4450. DOI:10. 1128/jvi. 79. 7. 4440-4450. 2005.
[22]Zavala G, Pretto C, Chow YH, et al. Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus[J]. Virology, 2003, 312(1):95-105. DOI:10. 1016/s0042-6822(03)00205-8.
[23]Allen TE, Sherrill KJ, Crispell SM, et al. The jaagsiekte sheep retrovirus envelope gene induces transformation of the avian fibroblast cell line DF-1 but does not require a conserved SH2 binding domain[J]. J Gen Virol, 2002, 83(pt 11):2733-2742. DOI:10. 1099/0022-1317-83-11-2733.
[24]Wootton SK, Metzger MJ, Hudkins KL, et al. Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus(JSRV)closely resembles lung cancer in sheep infected with JSRV[J].Retrovirology, 2006, 3:94. DOI:10. 1186/1742-4690-3-94.
[25]张宇飞，刘月，王专家，等.绵羊肺腺瘤病毒pEGFPC1/exJSRV-env构建及引起NIH3T3细胞恶性转化的研究[J].病毒学报，2014, 30(3):268-277. DOI:10. 13242/j. cnki. bingduxuebao. 002471.
[26]石晶，张宇飞，刘淑英.绵羊肺腺瘤病毒真核表达质粒pcDNA3. 1（+）/exJSRV-env引起体内和体外细胞发生的转化[J].中国兽医学报，2017, 37(5):787-793,798. DOI:10. 16303/j. cnki. 1005-4545. 2017. 05. 04.
[27]杨小林，杜晓悦，段续接，等. JSRV-env慢病毒过表达载体的构建及BEAS-2B细胞稳转株的建立[J].中国兽医学报，2023, 43(11):2228-2236. DOI:10. 16303/j. cnki. 1005-4545. 2023. 11. 05.
[28]杨惠，刘淑英. JSRV-env慢病毒过表达载体构建及其对NIH3T3细胞增殖的影响[J].中国农业大学学报，2020, 25(7):120-127.
[29]Caporale M, Cousens C, Centorame P, et al.Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep[J]. J Virol, 2006, 80(16):8030-8037. DOI:10. 1128/jvi. 00474-06.
[30]段续接，杨惠，孙志伟，等.基于转录组学分析自然感染绵羊肺腺瘤病毒患羊肺肿瘤组织中转录差异基因及病毒致瘤机制的研究[J].中国预防兽医学报，2024,46(2):185-194.
[31]段续接，刘淑英. Hippo信号通路生物学作用研究进展[J].生命科学，2023, 35(10):1249-1258. DOI:10. 13376/j. cbls/2023137.
[32]Liu SL, Duh FM, Lerman MI, et al. Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins[J]. J Virol, 2003, 77(5):2850-2858. DOI:10. 1128/jvi. 77. 5. 2850-2858. 2003.
[33]Liu SL, Miller AD. Oncogenic transformation by the jaagsiekte sheep retrovirus envelope protein[J].Oncogene, 2007, 26(6):789-801. DOI:10. 1038/sj.onc. 1209850.
[34]么宏强，孙丽红，骆爽，等. JSRV-Env诱导转染TC-1、TC-1-Hyal2细胞后对AKT和ERK表达的影响[J].病毒学报，2016, 32(3):283-291. DOI:10. 13242/j.cnki. bingduxuebao. 002941.
[35]Hull S, Fan H. Mutational analysis of the cytoplasmic tail of jaagsiekte sheep retrovirus envelope protein[J]. J Virol, 2006, 80(16):8069-8080. DOI:10. 1128/jvi. 00013-06.
[36]Liu SL, Miller AD. Transformation of madin-darby canine kidney epithelial cells by sheep retrovirus envelope proteins[J]. J Virol, 2005, 79(2):927-933.DOI:10. 1128/jvi. 79. 2. 927-933. 2005.
[37]Liu SL, Lerman MI, Miller AD. Putative phosphatidylinositol 3-kinase(PI3K)binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activation[J]. J Virol, 2003, 77(14):7924-7935. DOI:10. 1128/jvi. 77. 14. 7924-7935. 2003.
[38]张良，黄家荣，孙志伟，等.自然感染绵羊肺腺瘤病毒病肺组织中凋亡相关因子的表达分析[J].中国兽医学报，2023, 43(6):1263-1269, 1296. DOI:10. 16303/j.cnki. 1005-4545. 2023. 06. 22.
[39]段续接，杨惠，刘淑英. JSRV Env通过Akt/mTOR信号通路调控绵羊绒毛膜滋养层细胞增殖[J].动物医学进展，2021, 42(9):47-52. DOI:10. 16437/j.cnki. 1007-5038.
[40]Sun X, Du F, Liu S. Modulation of autophagy in exJSRV-env-transfected cells through the Akt/mTOR and MAPK signaling pathway[J]. Biochem Biophys Res Commun, 2017, 485(3):672-678. DOI:10. 1016/j. bbrc. 2017. 02. 099.
[41]黄家荣，杨惠，孙志伟，等.自然感染OPA的羔羊肺组织中自噬相关因子的表达分析[J].中国兽医学报，2020, 40(5):916-923, 932. DOI:10. 16303/j.cnki. 1005-4545. 2020. 05. 08.
[42]Wang X, Liu S. Endogenous Jaagsiekte sheep retrovirus envelope protein promotes sheep trophoblast cell fusion by activating PKA/MEK/ERK1/2 signaling[J]. Theriogenology, 2022, 193:58-67. DOI:10. 1016/j. theriogenology. 2022. 09. 003.
[43]杨惠，刘淑英. exJSRV和enJSRV致瘤机制的研究进展[J].中国兽医科学，2018, 48(4):500-505. DOI:10. 16656/j. issn. 1673-4696. 2018. 0077.
[44]张月梅，赵世华，么宏强，等.绵羊肺腺瘤病毒SU蛋白与Hyal-2蛋白的结合域研究[J].动物医学进展，2016, 37(4):49-53. DOI:10. 3969/j. issn. 1007-5038. 2016. 04. 010.
[45]Spencer TE, Mura M, Gray CA, et al. Receptor usage and fetal expression of ovine endogenous betaretroviruses:implications for coevolution of endogenous and exogenous retroviruses[J]. J Virol,2003, 77(1):749-753. DOI:10. 1128/jvi. 77. 1. 749-753. 2003.
[46]Murcia PR, Arnaud F, Palmarini M. The transdominant endogenous retrovirus enJS56A1associates with and blocks intracellular trafficking of Jaagsiekte sheep retrovirus Gag[J]. J Virol, 2007, 81(4):1762-1772. DOI:10. 1128/jvi. 01859-06.
[47]Armezzani A, Arnaud F, Caporale M, et al. The signal peptide of a recently integrated endogenous sheep betaretrovirus envelope plays a major role in eluding gagmediated late restriction[J]. J Virol, 2011, 85(14):7118-7128. DOI:10. 1128/jvi. 00407-11.
[48]Gray ME, Meehan J, Sullivan P, et al. Ovine pulmonary adenocarcinoma:a unique model to improve lung cancer research[J]. Front Oncol, 2019, 9:335.DOI:10. 3389/fonc. 2019. 00335.
[49]Yu DL, Chow N, Wootton SK. JSRV intragenic enhancer element increases expression from a heterologous promoter and promotes high level AAVmediated transgene expression in the lung and liver of mice[J]. Viruses, 2020, 12(11):E1266. DOI:10. 3390/v12111266.
[50]Rosales Gerpe MC, van Lieshout LP, Domm JM, et al. The U3 and env proteins of jaagsiekte sheep retrovirus and enzootic nasal tumor virus both contribute to tissue tropism[J]. Viruses, 2019, 11(11):E1061.DOI:10. 3390/v11111061.
[51]罗军荣. JSRV检测及JSRV转录起始调节基因LTR致瘤机制相关性研究[D].呼和浩特：内蒙古农业大学，2009.
[52]Sonawane GG, Tripathi BN, Kumar R, et al.Diagnosis and prevalence of ovine pulmonary adenocarcinoma in lung tissues of naturally infected farm sheep[J]. Vet World, 2016, 9(4):365-370. DOI:10. 14202/vetworld. 2016. 365-370.
[53]刘淑英.绵羊肺腺瘤病毒NM株基因组全序列的研究[D].呼和浩特：内蒙古农业大学，2004.
[54]刘然，张琳，刘淑英.外源性绵羊肺腺瘤病毒实时荧光RPA检测方法的建立[J].中国兽医学报，2023, 43(2):278-284. DOI:10. 16303/j. cnki. 1005-4545. 2023. 02. 09.
[55]陈思旭，王多智，徐先达，等.绵羊肺腺瘤病毒完整囊膜蛋白的多克隆抗体制备与特异性检测[J].中国兽医科学，2021, 51(12):1548-1553. DOI:10. 16656/j.issn. 1673-4696. 2021. 0193.
[56]Mahmoud NA, Elshafei AM, Almofti YA. A novel strategy for developing vaccine candidate against Jaagsiekte sheep retrovirus from the envelope and gag proteins:an in-silico approach[J]. BMC Vet Res,2022, 18(1):343. DOI:10. 1186/s12917-022-03431-0.
[57]Rosato G, Abril C, Hilbe M, et al. A combined approach for detection of ovine small ruminant retrovirus co-infections[J]. Viruses, 2023, 15(2):376. DOI:10. 3390/v15020376.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004581
中图分类号:S852.65
引用信息:
[1]段续接,张培,刘淑英.绵羊肺腺瘤病毒致病机制研究进展[J].病毒学报,2024,40(06):1476-1485.DOI:10.13242/j.cnki.bingduxuebao.004581.
基金信息:
国家自然科学基金项目（项目号：32072819、32360863）,题目：绵羊肺腺瘤病毒LTR调控病毒转录与核膜蛋白SUN2互作机制的研究、JSRV-NM囊膜蛋白诱导线粒体自噬的作用机制及代谢组学研究; 内蒙古科技重大专项计划资助项目（项目号：2021ZD0010）,题目：牛羊支原体肺炎和病毒性呼吸道疾病的防控技术研发与示范; 内蒙古自治区教育厅高校创新团队建设项目（项目号：BR22-13-08）,题目：牛羊疫病防控与发育工程创新团队;内蒙古自治区教育厅创新团队项目（项目号：NMGIRT2412）,题目：兽医基础与牛羊疫病防控技术研发创新团队; 研究生科研创新资助项目（项目号：B20231072Z、B20210174Z）,题目：绵羊肺腺瘤病毒囊膜蛋白诱导线粒体自噬的作用机制及代谢组学研究、JSRV的“体外拯救”及其诱导绵羊抗病毒免疫应答机制初探~~
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