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口蹄疫病毒（Foot-and-mouth disease virus, FMDV）是一种严重危害偶蹄动物的急性烈性传染病病原体，具有致死率高与传播力强的显著特征，可突破地理阻隔持续传播，对畜牧业健康发展及相关畜产品国际贸易造成严重影响。这种典型的致病特性与其独特的基因组结构密切相关，尤其是5'端非翻译区（5'untranslated region, 5'UTR）这一关键区域，其长度与功能复杂性均居小核糖核酸病毒科之首。FMDV的5'UTR在病毒生命周期中发挥多重调控功能，包括启动蛋白质翻译、激活病毒核酸复制、调节细胞免疫信号、参与基因组RNA包装与维持病毒粒子稳定性等，是FMDV产生感染性病毒颗粒的关键结构元件。本文以病毒复制周期为主线，系统综述FMDV 5'UTR调控病毒增殖的作用机制，旨在为病毒生物学特性探究以及新型靶向抗病毒药物的研发提供理论参考。
Abstract：Foot-and-mouth disease virus(FMDV) is a highly contagious and acute infectious pathogen that seriously endangers the cloven-hoofed animals. With high mortality and robust transmissibility, the virus could traverses the geographic barriers to perpetuate its spread, rendering serious influence on healthy development of the livestock industry and international trade in animal-derived products. This typical pathogenic characteristic is closely associated with its unique genomic architecture, particularly the 5' untranslated region(5' UTR), a critical domain that ranks first among the family Picornaviridae in both length and functional complexity. The FMDV 5' UTR fulfils multiple regulatory functions throughout the viral life cycle, encompassing protein translation initiation, viral nucleic acid replication activation, immune signaling modulation, genomic RNA packaging and virion stabilisation, thereby serving as a critical structural element for the production of infectious viral particles in FMDV. Based on the viral replication cycle, this review summarizes the mechanisms of the FMDV 5' UTR in regulating viral proliferation, aiming to provide a theoretical reference for exploring viral biological characteristics and developing novel targeted antiviral therapeutics.
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HOU Zhengyang, GUO Huichen, WU Jinen. Research Progress on the Molecular Mechanism of 5'UTR Regulating Viral Proliferation
in FMDV[J]. Chin J Virol, XXXX, XX(XX):1-11.
基本信息:
中图分类号:S852.65
引用信息:
[1]侯正阳,郭慧琛,吴金恩.口蹄疫病毒5'UTR调控病毒增殖的分子机制研究进展[J].病毒学报().
基金信息:
国家自然科学基金项目（项目号：32473012）,题目：壳聚糖/TLR7激动剂双效水凝胶缓释矿化口蹄疫病毒样颗粒的免疫机制研究;国家自然科学基金项目（项目号：32503057）,题目：Th1/Tfh细胞调控口蹄疫病毒诱导长效免疫的机制研究
2026-09-22
2026-09-22
2026-09-22