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流感病毒引发的急性呼吸道传染病可以在全球引发流行，严重危害公共卫生安全。固有免疫作为抵抗流感病毒的第一道防线，在识别与清除流感病毒方面起着不可忽视的作用。本文介绍了固有免疫细胞识别流感病毒的机制，重点论述了固有淋巴样细胞、单核-巨噬细胞、中性粒细胞以及树突状细胞对流感病毒产生的免疫应答，并介绍了单细胞测序技术在固有免疫应答中的应用，以期为流感病毒的研究和治疗提供思路。
Abstract：Acute respiratory infectious diseases caused by influenza viruses can cause serious harm to public-health security and global epidemics. As the first line of defense against influenza viruses, innate immunity plays an important part in identifying and eliminating influenza viruses. Herein, we introduce the mechanism of recognition by innate immune cells of influenza viruses. We focus on the immune response of innate lymphoid cells, mononuclear macrophages, neutrophils, and dendritic cells to influenza viruses. We discuss application of single-cell sequencing in the innate immune response to provide ideas for the research and treatment of influenza viruses.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.004511
中图分类号:R392
引用信息:
[1]邵成龙,张少言,吴显伟,等.单细胞测序技术在流感病毒诱导的固有免疫应答中的应用[J].病毒学报,2024,40(03):598-608.DOI:10.13242/j.cnki.bingduxuebao.004511.
基金信息:
国家自然科学基金面上项目（项目号：82174286）,题目：基于H1N1感染气道上皮协同固有免疫活化研究中药羌竹清感方肺损伤保护的效应机制;国家自然科学基金青年科学基金项目（项目号：82205005）,题目：羌竹清感方及拆方对病毒性肺炎上皮/内皮损伤与MΦ介导免疫活化放大互作关键环节的效应机制研究; 上海市2021年度“科技创新行动计划”（项目号：21Y21920400）,题目：以流感为模式病种研究中医药辨治突发急性呼吸道传染病关键证候方案的循证评价研究;上海市2021年度“科技创新行动计划”（项目号：21S21900200）,题目：羌竹清感颗粒治疗流行感冒的临床前研究; 上海市加强公共卫生体系建设三年行动计划（2023-2025年）（项目号：GWVI-11.1-08）,题目：重大传染病中医药防治~~
2024-02-05
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2024-03-04
2024-05-14
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