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人腺病毒（Human adenovirus, HAdV）是一种引发多种人类疾病的病原体，因其高传染性、在高度密闭、拥挤的环境中容易导致暴发流行，对人类健康构成严重威胁。HAdV的入侵依赖于宿主细胞表面的特定受体，这些受体在病毒附着和入侵过程中扮演关键角色。此外，宿主细胞内的多种因子在病毒复制周期的不同阶段发挥重要功能，包括病毒基因组转录、翻译、复制，以及子代病毒的组装。这些宿主因子涉及细胞分化、信号传导、免疫调控等多个细胞生命过程。本文综述了HAdV入侵所依赖的宿主受体及病毒复制相关的关键宿主因子的最新研究进展，以期加深对HAdV致病机制的理解，并为新型抗病毒药物的开发提供参考。
Abstract：Human adenovirus(HAdV) is a pathogen responsible for a wide range of human diseases and poses a significant threat to public health due to its high transmissibility, particularly in enclosed and densely populated environments where outbreaks can readily occur. The entry of HAdV into host cells depends on specific cell surface receptors that play critical roles in viral attachment and internalization. Moreover, a variety of host cellular factors are involved at different stages of the viral replication cycle, including transcription, translation, genome replication, and the assembly of progeny virions. These host factors participate in essential cellular processes such as differentiation, signal transduction, and immune regulation. This review summarizes recent advances in the identification and characterization of cellular receptors required for HAdV entry, as well as key host factors involved in its replication. The aim is to deepen our understanding of HAdV pathogenesis and provide a foundation for the development of novel antiviral strategies.
[1]Radke JR, Cook JL. Human adenovirus infections:update and consideration of mechanisms of viral persistence[J]. Curr Opin Infect Dis, 2018, 31(3):251-256. DOI:10. 1097/QCO. 0000000000000451.
[2]Zhu Y, Xu B, Li C, et al. A multicenter study of viral aetiology of community-acquired pneumonia in hospitalized children in Chinese mainland[J]. Virol Sin,2021, 36(6):1543-1553. DOI:10. 1007/s12250-021-00437-0.
[3]Feng Q, Wang J, Wang X, et al. Clinical epidemiological characteristics of hospitalized pediatric viral community-acquired pneumonia in China[J]. J Infect, 2025, 90(3):106450. DOI:10. 1016/j.jinf. 2025. 106450.
[4]杨传宇，赵林清.人腺病毒流行病学研究进展[J].病毒学报，2021,37(03):732-739. DOI:10. 13242/j. cnki.bingduxuebao. 003974.
[5]颜可昕，王佳楠，杨乐涵，等.人腺病毒中和抗体研究进展[J].病毒学报，2025,41(05):1581-1593. DOI:10. 13242/j. cnki. bingduxuebao. 004639.
[6]Howley P M, Knipe D M. Fields virology[M].Seventh edition. Philadelphia:Wolters Kluwer, 2021.
[7]Akello JO, Kamgang R, Barbani MT, et al. Genomic analyses of human adenoviruses unravel novel recombinant genotypes associated with severe infections in pediatric patients[J]. Sci Rep, 2021, 11(1):24038.DOI:10. 1038/s41598-021-03445-y.
[8]Ghebremedhin B. Human adenovirus:Viral pathogen with increasing importance[J]. Eur J Microbiol Immunol(Bp), 2014, 4(1):26-33. DOI:10. 1556/EuJMI. 4. 2014. 1. 2.
[9]Lion T. Adenovirus infections in immunocompetent and immunocompromised patients[J]. Clin Microbiol Rev,2014, 27(3):441-462. DOI:10. 1128/CMR. 00116-13.
[10]Liu MC, Xu Q, Li TT, et al. Prevalence of human infection with respiratory adenovirus in China:a systematic review and meta-analysis[J]. PLoS Negl Trop Dis, 2023, 17(2):e0011151. DOI:10. 1371/journal. pntd. 0011151.
[11]Gallardo J, Pérez-Illana M, Martín-González N, et al.Adenovirus structure:what is new?[J]. Int J Mol Sci,2021, 22(10):5240. DOI:10. 3390/ijms22105240.
[12]Nemerow GR, Pache L, Reddy V, et al. Insights into adenovirus host cell interactions from structural studies[J]. Virology, 2009, 384(2):380-388. DOI:10. 1016/j. virol. 2008. 10. 016.
[13]Coyne CB, Bergelson JM. CAR:a virus receptor within the tight junction[J]. Adv Drug Deliv Rev,2005, 57(6):869-882. DOI:10. 1016/j.addr. 2005. 01. 007.
[14]Stasiak AC, Stehle T. Human adenovirus binding to host cell receptors:a structural view[J]. Med Microbiol Immunol, 2020, 209(3):325-333. DOI:10. 1007/s00430-019-00645-2.
[15]Tsoukas RL, Volkwein W, Gao J, et al. A human in vitro model to study adenoviral receptors and virus cell interactions[J]. Cells, 2022, 11(5):841. DOI:10. 3390/cells11050841.
[16]Cardone J, Le Friec G, Kemper C. CD46 in innate and adaptive immunity:an update[J]. Clin Exp Immunol,2011, 164(3):301-311. DOI:10. 1111/j. 1365-2249. 2011. 04400. x.
[17]Zhu W, Zhou Y, Guo L, et al. Biological function of sialic acid and sialylation in human health and disease[J]. Cell Death Discov, 2024, 10(1):415. DOI:10. 1038/s41420-024-02180-3.
[18]Varki A. Sialic acids in human health and disease[J].Trends Mol Med, 2008, 14(8):351-360. DOI:10. 1016/j. molmed. 2008. 06. 002.
[19]Arnberg N. Adenovirus receptors:implications for tropism, treatment and targeting[J]. Rev Med Virol,2009, 19(3):165-178. DOI:10. 1002/rmv. 612.
[20]Chandra N, Fr?ngsmyr L, Imhof S, et al. Sialic acidcontaining glycans as cellular receptors for ocular human adenoviruses:implications for tropism and treatment[J]. Viruses, 2019, 11(5):395. DOI:10. 3390/v11050395.
[21]Lenman A, Manuel Liaci A, Liu Y, et al. Human adenovirus 52 uses sialic acid-containing glycoproteins and the Coxsackie and adenovirus receptor for binding to target cells[J]. PLoS Pathog, 2015, 11(2):e1004657. DOI:10. 1371/journal. ppat. 1004657.
[22]Myo Min KK, Ffrench CB, McClure BJ, et al.Desmoglein-2 as a cancer modulator:friend or foe?[J].Front Oncol, 2023, 13:1327478. DOI:10. 3389/fonc. 2023. 1327478.
[23]Zhang J, Ma K, Wang X, et al. Desmoglein 2(DSG2)is A receptor of human adenovirus type 55 causing adult severe community-acquired pneumonia[J]. Virol Sin,2021, 36(6):1400-1410. DOI:10. 1007/s12250-021-00414-7.
[24]Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology[J].Nature, 2007, 446(7139):1030-1037. DOI:10. 1038/nature05817.
[25]Dechecchi MC, Melotti P, Bonizzato A, et al. Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5[J]. J Virol, 2001, 75(18):8772-8780. DOI:10. 1128/jvi. 75. 18. 8772-8780. 2001.
[26]Smith TAG, Idamakanti N, Rollence ML, et al.Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice[J]. Hum Gene Ther, 2003, 14(8):777-787. DOI:10. 1089/104303403765255165.
[27]Rajan A, Palm E, Trulsson F, et al. Heparan sulfate is a cellular receptor for enteric human adenoviruses[J].Viruses, 2021, 13(2):298. DOI:10. 3390/v13020298.
[28]Pang X, He X, Qiu Z, et al. Targeting integrin pathways:mechanisms and advances in therapy[J].Signal Transduct Target Ther, 2023, 8(1):1. DOI:10. 1038/s41392-022-01259-6.
[29]Hussein HAM, Walker LR, Abdel-Raouf UM, et al.Beyond RGD:virus interactions with integrins[J]. Arch Virol, 2015, 160(11):2669-2681. DOI:10. 1007/s00705-015-2579-8.
[30]Rajan A, David Persson B, Fr?ngsmyr L, et al. Enteric species F human adenoviruses use laminin-binding integrins as co-receptors for infection of ht-29 cells[J].Sci Rep, 2018, 8(1):10019. DOI:10. 1038/s41598-018-28255-7.
[31]Short JJ, Vasu C, Holterman MJ, et al. Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors[J]. Virus Res, 2006, 122(1-2):144-153. DOI:10. 1016/j. virusres. 2006. 07. 009.
[32]Liu S, Wei S, Sun Y, et al. Molecular characteristics,functional definitions, and regulatory mechanisms for cross-presentation mediated by the major histocompatibility complex:a comprehensive review[J]. Int J Mol Sci, 2023, 25(1):196. DOI:10. 3390/ijms25010196.
[33]Castro R, Adair JH, Mastro AM, et al. VCAM-1-targeted nanoparticles to diagnose, monitor and treat atherosclerosis[J]. Nanomedicine(Lond), 2024, 19(8):723-735. DOI:10. 2217/nnm-2023-0282.
[34]Chu Y, Heistad D, Cybulsky MI, et al. Vascular cell adhesion molecule-1 augments adenovirus-mediated gene transfer[J]. Arterioscler Thromb Vasc Biol,2001, 21(2):238-242. DOI:10. 1161/01.atv. 21. 2. 238.
[35]Zani IA, Stephen SL, Mughal NA, et al. Scavenger receptor structure and function in health and disease[J].Cells, 2015, 4(2):178-201. DOI:10. 3390/cells4020178.
[36]Stichling N, Suomalainen M, Flatt JW, et al. Lung macrophage scavenger receptor SR-A6(MARCO)is an adenovirus type-specific virus entry receptor[J]. PLoS Pathog, 2018, 14(3):e1006914. DOI:10. 1371/journal. ppat. 1006914.
[37]Camire RM. Blood coagulation factor X:molecular biology, inherited disease, and engineered therapeutics[J]. J Thromb Thrombolysis, 2021, 52(2):383-390.DOI:10. 1007/s11239-021-02456-w.
[38]Kalyuzhniy O, Di Paolo NC, Silvestry M, et al.Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo[J]. Proc Natl Acad Sci USA,2008, 105(14):5483-5488. DOI:10. 1073/pnas. 0711757105.
[39]David Persson B, Lenman A, Fr?ngsmyr L, et al.Lactoferrin-hexon interactions mediate CARindependent adenovirus infection of human respiratory cells[J]. J Virol, 2020, 94(14):e00542-20. DOI:10. 1128/JVI. 00542-20.
[40]孙西魁，刘兴龙，冯立强.人腺病毒感染动物模型的研究进展[J].病毒学报，2016, 32(6):810-816. DOI:10. 13242/j. cnki. bingduxuebao. 003081.
[41]Wang H, Beyer I, Persson J, et al. A new human DSG2-transgenic mouse model for studying the tropism and pathology of human adenoviruses[J]. J Virol,2012, 86(11):6286-6302. DOI:10. 1128/JVI. 00205-12.
[42]Tallone T, Malin S, Samuelsson A, et al. A mouse model for adenovirus gene delivery[J]. Proc Natl Acad Sci USA, 2001, 98(14):7910-7915. DOI:10. 1073/pnas. 141223398.
[43]Hensen LCM, Hoeben RC, Bots STF. Adenovirus receptor expression in cancer and its multifaceted role in oncolytic adenovirus therapy[J]. Int J Mol Sci, 2020,21(18):6828. DOI:10. 3390/ijms21186828.
[44]Guo B, McMillan BJ, Blacklow SC. Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction[J]. Curr Opin Struct Biol,2016, 41:38-45. DOI:10. 1016/j. sbi. 2016. 05. 012.
[45]Bauer M, Flatt JW, Seiler D, et al. The E3 ubiquitin ligase mind bomb 1 controls adenovirus genome release at the nuclear pore complex[J]. Cell Rep, 2019, 29(12):3785-3795. e8. DOI:10. 1016/j.celrep. 2019. 11. 064.
[46]Kotha PLN, Sharma P, Kolawole AO, et al.Adenovirus entry from the apical surface of polarized epithelia is facilitated by the host innate immune response[J]. PLoS Pathog, 2015, 11(3):e1004696. DOI:10. 1371/journal. ppat. 1004696.
[47]Xie Y, Mei H, Wang W, et al. ALCAM is an entry factor for severe community acquired Pneumoniaassociated Human adenovirus species B[J]. Nat Commun, 2024, 15(1):10889. DOI:10. 1038/s41467-024-55261-3.
[48]Hauler F, Mallery DL, McEwan WA, et al. AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization[J]. Proc Natl Acad Sci USA,2012, 109(48):19733-19738. DOI:10. 1073/pnas. 1210659109.
[49]McEwan WA, Tam JCH, Watkinson RE, et al.Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21[J]. Nat Immunol, 2013, 14(4):327-336. DOI:10. 1038/ni. 2548.
[50]Xu D, Lu W. Defensins:a double-edged sword in host immunity[J]. Front Immunol, 2020, 11:764. DOI:10. 3389/fimmu. 2020. 00764.
[51]Flatt JW, Kim R, Smith JG, et al. An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5[J]. PLoS One, 2013, 8(4):e61571. DOI:10. 1371/journal.pone. 0061571.
[52]Herhaus L. TBK1(TANK-binding kinase 1)-mediated regulation of autophagy in health and disease[J]. Matrix Biol, 2021, 100-101:84-98. DOI:10. 1016/j.matbio. 2021. 01. 004.
[53]Pied N, Daussy CF, Denis Z, et al. TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape[J]. PLoS Pathog, 2022, 18(7):e1010736. DOI:10. 1371/journal. ppat. 1010736.
[54]Tang D, Kang R, Zeh HJ, et al. The multifunctional protein HMGB1:50 years of discovery[J]. Nat Rev Immunol, 2023, 23(12):824-841. DOI:10. 1038/s41577-023-00894-6.
[55]Watt F, Molloy PL. High mobility group proteins 1 and2 stimulate binding of a specific transcription factor to the adenovirus major late promoter[J]. Nucleic Acids Res,1988, 16(4):1471-1486. DOI:10. 1093/nar/16. 4. 1471.
[56]Tang Z, Zang N, Fu Y, et al. HMGB1 mediates HAdV-7 infection-induced pulmonary inflammation in mice[J]. Biochem Biophys Res Commun, 2018, 501(1):1-8. DOI:10. 1016/j. bbrc. 2018. 03. 145.
[57]Tao Y, Zhong C, Zhu J, et al. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2[J]. Nucleic Acids Res, 2017, 45(10):5707-5719. DOI:10. 1093/nar/gkx142.
[58]Kamel H, Shete V, Gadamsetty S, et al. HBO1/KAT7/MYST2 HAT complex regulates human adenovirus replicative cycle[J]. Heliyon, 2024, 10(7):e28827. DOI:10. 1016/j. heliyon. 2024. e28827.
[59]Nininahazwe L, Liu B, He C, et al. The emerging nature of ubiquitin-specific protease 7(USP7):a new target in cancer therapy[J]. Drug Discov Today, 2021,26(2):490-502. DOI:10. 1016/j. drudis. 2020. 10. 028.
[60]Meredith M, Orr A, Everett R. Herpes simplex virus type 1 immediate-early protein Vmw110 binds strongly and specifically to a 135-kDa cellular protein[J].Virology, 1994, 200(2):457-469. DOI:10. 1006/viro. 1994. 1209.
[61]Ching W, Koyuncu E, Singh S, et al. A ubiquitinspecific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation[J].PLoS Pathog, 2013, 9(3):e1003273. DOI:10. 1371/journal. ppat. 1003273.
[62]Fonseca GJ, Cohen MJ, Mymryk JS. Adenovirus E1A recruits the human Paf1 complex to enhance transcriptional elongation[J]. J Virol, 2014, 88(10):5630-5637. DOI:10. 1128/JVI. 03518-13.
[63]van Gent M, Sparrer KMJ, Gack MU. TRIM proteins and their roles in antiviral host defenses[J]. Annu Rev Virol, 2018, 5(1):385-405. DOI:10. 1146/annurevvirology-092917-043323.
[64]Sun N, Zhang J, Zhang C, et al. Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A[J]. J Virol, 2023, 97(8):e0070023. DOI:10. 1128/jvi. 00700-23.
[65]Zhang W, Li Y, Xin S, et al. The emerging roles of IFIT3 in antiviral innate immunity and cellular biology[J]. J Med Virol, 2023, 95(1):e28259. DOI:10. 1002/jmv. 28259.
[66]Chikhalya A, Dittmann M, Zheng Y, et al. Human IFIT3 protein induces interferon signaling and inhibits adenovirus immediate early gene expression[J]. mBio,2021, 12(6):e0282921. DOI:10. 1128/mBio. 02829-21.
[67]Sadeghpour S, Khodaee S, Rahnama M, et al. Human APOBEC3 variations and viral infection[J]. Viruses,2021, 13(7):1366. DOI:10. 3390/v13071366.
[68]Stavrou S, Ross S R. APOBEC3 proteins in viral immunitv[J]. J Immunol, 2015, 195(10):4565-4570.DOI:10. 4049/jimmunol. 1501504.
[69]Chen Y, Hu J, Cai X, et al. APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription[J]. Antiviral Res, 2018, 149:16-25.DOI:10. 1016/j. antiviral. 2017. 11. 006.
[70]Lejeune N, Mathieu S, Decloux A, et al. The APOBEC3B cytidine deaminase is an adenovirus restriction factor[J]. PLoS Pathog, 2023, 19(2):e1011156. DOI:10. 1371/journal. ppat. 1011156.
[71]Lejeune N, Poulain F, Willemart K, et al. Infection of bronchial epithelial cells by the human adenoviruses A12, B3, and C2 differently regulates the innate antiviral effector APOBEC3B[J]. J Virol, 2021, 95(13):e0241320. DOI:10. 1128/JVI. 02413-20.
[72]G?ttig L, Wei?C, Stubbe M, et al. Apobec3A deamination functions are involved in antagonizing efficient human adenovirus replication and gene expression[J]. mBio, 2023, 14(3):e0347822. DOI:10. 1128/mbio. 03478-22.
[73]Naicker D, Rhoda C, Sunda F, et al. Unravelling the intricate roles of FAM111A and FAM111B:from protease-mediated cellular processes to disease implications[J]. Int J Mol Sci, 2024, 25(5):2845.DOI:10. 3390/ijms25052845.
[74]Fine DA, Rozenblatt-Rosen O, Padi M, et al.Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor[J]. PLoS Pathog, 2012, 8(10):e1002949. DOI:10. 1371/journal. ppat. 1002949.
[75]Ip WH, Wilkens B, Solomatina A, et al. Differential regulation of cellular FAM111B by human adenovirus C type 5 E1 oncogenes[J]. Viruses, 2021, 13(6):1015.DOI:10. 3390/v13061015.
[76]G?ttig L, Jummer S, Staehler L, et al. The human adenovirus PI3K-Akt activator E4orf1 is targeted by the tumor suppressor p53[J]. J Virol, 2024, 98(4):e0170123. DOI:10. 1128/jvi. 01701-23.
[77]Guo H, Shen S, Li Y, et al. Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5E3 ligase for p53 degradation[J]. Biochem Biophys Res Commun, 2019, 516(4):1242-1247. DOI:10. 1016/j.bbrc. 2019. 07. 028.
[78]Schreiner S, Wimmer P, Sirma H, et al. Proteasomedependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells[J]. J Virol,2010, 84(14):7029-7038. DOI:10. 1128/JVI. 00074-10.
[79]Bürck C, Mund A, Berscheminski J, et al. KAP1 is a host restriction factor that promotes human adenovirus E1B-55K SUMO modification[J]. J Virol, 2015, 90(2):930-946. DOI:10. 1128/JVI. 01836-15.
[80]Schreiner S, Kinkley S, Bürck C, et al. SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection[J]. PLoS Pathog,2013, 9(11):e1003775. DOI:10. 1371/journal.ppat. 1003775.
[81]Reichel A, Stilp AC, Scherer M, et al. Chromatinremodeling factor SPOC1 acts as a cellular restriction factor against human cytomegalovirus by repressing the major immediate early promoter[J]. J Virol, 2018, 92(14):e00342-18. DOI:10. 1128/JVI. 00342-18.
[82]Zhang L, Duan Y, Wang W, et al. Autophagy induced by human adenovirus B7 structural protein VI inhibits viral replication[J]. Virol Sin, 2023, 38(5):709-722.DOI:10. 1016/j. virs. 2023. 08. 002.
[83]Snaider S, Zheng Y, Hearing P. Rb-E2F-HDAC repressor complexes control interferon-induced repression of adenovirus to promote persistent infection[J]. J Virol, 2022, 96(11):e0044222. DOI:10. 1128/jvi. 00442-22.
[84]Wang X, Zhang Q, Zhou Z, et al. Retinoic acid receptor β, a potential therapeutic target in the inhibition of adenovirus replication[J]. Antiviral Res, 2018, 152:84-93. DOI:10. 1016/j. antiviral. 2018. 01. 014.
[85]Deryckere F, Ebenau-Jehle C, Wold WS, et al. Tumor necrosis factor alpha increases expression of adenovirus E3 proteins[J]. Immunobiology, 1995, 193(2-4):186-192. DOI:10. 1016/s0171-2985(11)80542-5.
[86]Subramanian T, Zhao LJ, Chinnadurai G. Interaction of CtBP with adenovirus E1A suppresses immortalization of primary epithelial cells and enhances virus replication during productive infection[J].Virology, 2013, 443(2):313-320. DOI:10. 1016/j.virol. 2013. 05. 018.
[87]Mai J, Stubbe M, Hofmann S, et al. PML alternative splice products differentially regulate HAdV productive infection[J]. Microbiol Spectr, 2022, 10(4):e0078522. DOI:10. 1128/spectrum. 00785-22.
[88]Stubbe M, Mai J, Paulus C, et al. Viral DNA binding protein SUMOylation promotes PML nuclear body localization next to viral replication centers[J]. mBio,2020, 11(2):e00049-20. DOI:10. 1128/mBio. 00049-20.
[89]Berscheminski J, Wimmer P, Brun J, et al. Sp100isoform-specific regulation of human adenovirus 5 gene expression[J]. J Virol, 2014, 88(11):6076-6092.DOI:10. 1128/JVI. 00469-14.
[90]Berscheminski J, Brun J, Speiseder T, et al. Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation[J]. Oncogene, 2016, 35(24):3178-3189. DOI:10. 1038/onc. 2015. 378.
[91]Radko S, Koleva M, James KMD, et al. Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth[J]. J Virol, 2014, 88(22):13469-13481. DOI:10. 1128/JVI. 02538-14.
[92]Ismail AM, Saha A, Lee JS, et al. RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa[J]. PLoS Pathog, 2022, 18(6):e1010588. DOI:10. 1371/journal. ppat. 1010588.
[93]Luan J, Zhou Y, Wang X, et al. Single-cell RNA sequencing analysis of liver reveals the enhanced entry and release abilities of human adenovirus F41, partially explaining acute hepatitis in children[J]. J Infect, 2022,85(3):334-363. DOI:10. 1016/j. jinf. 2022. 06. 007.
[94]Mese K, Bunz O, Schellhorn S, et al. Identification of novel human adenovirus candidates using the coxsackievirus and adenovirus receptor for cell entry[J].Virol J, 2020, 17(1):52. DOI:10. 1186/s12985-020-01318-w.
[95]Mundy RM, Baker AT, Bates EA, et al. Broad sialic acid usage amongst species D human adenovirus[J].NPJ Viruses, 2023, 1(1):1. DOI:10. 1038/s44298-023-00001-5.
[96]Feng Y, Yi C, Liu X, et al. Human desmoglein-2 and human CD46 mediate human adenovirus type 55infection, but human desmoglein-2 plays the major roles[J]. J Virol, 2020, 94(17):e00747-20. DOI:10. 1128/JVI. 00747-20.
[97]David Persson B, John L, Rafie K, et al. Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46[J]. Proc Natl Acad Sci USA, 2021, 118(3):e2020732118.DOI:10. 1073/pnas. 2020732118.
[98]Bates EA, Counsell JR, Alizert S, et al. In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications[J]. Viruses, 2021, 13(8):1483. DOI:10. 3390/v13081483.
[99]Zhang Q, Zhou Z, Fan Y, et al. Higher affinities of fibers with cell receptors increase the infection capacity and virulence of human adenovirus type 7 and type 55compared to type 3[J]. Microbiol Spectr, 2024, 12(1):e0109023. DOI:10. 1128/spectrum. 01090-23.
基本信息:
DOI：10.13242/j.cnki.bingduxuebao.250012
中图分类号:R373
引用信息:
[1]经玲,林颖,朱云,等.人腺病毒受体及复制相关宿主因子研究进展[J].病毒学报,2026,42(01):281-298.DOI:10.13242/j.cnki.bingduxuebao.250012.
基金信息:
国家自然科学基金（项目号：32470141）,题目：人腺病毒7型感染中的线粒体自噬反应及其作用机制研究; 北京市属医院科研培育项目（项目号：PX2024043）,题目：糖原合成酶激酶3A促进人腺病毒7型复制的分子机制及其作为潜在抗病毒治疗靶点研究; 国家自然科学基金（项目号：82072266）,题目：人腺病毒7型感染激活炎症小体的机制研究; 中国医学科学院医学与健康科技创新工程（项目号：2019-I2M-5-026）,题目：儿童危重感染诊断关键技术和免疫机制研究; 北京重大呼吸道传染病研究中心项目（项目号：BJRID2025-008）,题目：儿童危重症呼吸道感染病原谱系特征和基因遗传变异研究; 北京市卫生健康委员会改革与发展项目~~
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