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非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)感染引起的一种急性、出血性猪传染病,给疫情发生国家(地区)的养猪业造成重大经济损失。ASFV为双股DNA病毒,基因组含有150～167个开放阅读框(ORFs),可编码150～200种蛋白质,其中非结构蛋白有100余种。ASFV编码的酶、转录因子、调节宿主细胞功能蛋白和病毒免疫逃逸相关蛋白等作为重要的非结构蛋白,在病毒核苷酸代谢、DNA复制、修复、转录、蛋白修饰以及病毒与宿主细胞相互作用等过程中发挥重要作用,但仍有许多非结构蛋白的功能尚不明晰。因此,本文综述了ASFV非结构蛋白在病毒感染中的作用,以期为ASFV非结构蛋白的进一步研究提供参考。
Abstract：African swine fever(ASF)is an acute,lethal,and hemorrhagic porcine infectious disease caused by African swine fever virus(ASFV),and has significant economic and social consequences for the swine industry. ASFV is a double-stranded DNA virus. The viral genome contains between 150 and 167 open reading frames(ORFs),and encodes 150 to 200 proteins,around 100 of which are nonstructural proteins. ASFV-encoded enzymes,transcription factors,regulatory host cell function proteins and viral immune evasion proteins were regarded as the main nonstructural proteins. These proteins play important roles in nucleotide metabolism,DNA replication,repair,transcription,protein modification,and the interaction of ASFV with the host cell.Therefore,this paper reviews the roles of some ASFV nonstructural proteins in viral infection,further understands the pathogenesis of ASFV,and provides guidelines for further studies in the nonstructural protein of ASFV.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.003986
中图分类号:S852.65
引用信息:
[1]欧云文,刘俐君,贾宁,等.非结构蛋白在非洲猪瘟病毒感染中作用[J].病毒学报,2021,37(04):910-921.DOI:10.13242/j.cnki.bingduxuebao.003986.
基金信息:
国家重点研发计划项目（项目号：2017YFD0501800），题目：边境地区家养动物外来动物疫病监测溯源技术研究; 四川省科技计划资助（项目号：2019JDRC0110），题目：猪繁殖与呼吸综合征抗体检测试剂盒的研发与应用;四川省科技计划资助（项目号：2020JDRC0146），题目：猪细小病毒一步法快速显色环介导等温扩增（LAMP）试剂盒的研发~~
2018-12-11
2018
2021-03-23
2021-05-31
2021
3
2021-06-01
2021-06-01
2021-06-01