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宫颈癌与人乳头瘤病毒（Human papilloma virus,HPV）联系紧密，持续感染高危HPV是宫颈癌的主要诱因。表观遗传的重要修饰方式DNA甲基化在基因转录中发挥关键作用，基因甲基化水平异常与细胞癌变联系紧密。甲基化可表现在宿主细胞基因中，亦可表现在HPV病毒基因中，两者相互影响，在癌变进程中起着关键作用。本文总结了HPV基因甲基化改变，综述了宿主基因甲基化及与HPV基因甲基化关联，有助于进一步探讨宫颈癌的治疗新思路。
Abstract：Cervical cancer is strongly associated with human papillomavirus(HPV), and persistent infectionwith high-risk HPV types is recognized as the primary etiological factor. DNA methylation, a key epigeneticmodification, plays a pivotal role in the regulation of gene transcription, and aberrant methylation patterns areclosely linked to malignant transformation. Methylation changes occur not only in host cellular genes but also inviral genes of HPV, and the interplay between the two is critically involved in cervical carcinogenesis. Thisreview summarizes current findings on HPV genome methylation alterations and discusses host genemethylation and its correlation with HPV methylation, providing new insights for the development of potentialtherapeutic strategies for cervical cancer.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.250055
中图分类号:R737.33
引用信息:
[1]王伟,程书书,朱婷婷.人乳头瘤病毒相关宫颈癌中DNA甲基化的研究现状[J].病毒学报,2025,41(03):936-941.DOI:10.13242/j.cnki.bingduxuebao.250055.
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