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2023, 05, v.39 1455-1462
Ⅲ型干扰素抗流感病毒作用的研究进展
基金项目(Foundation): 病原微生物生物安全国家重点实验室自主研究课题(项目号:SKLPBS2209),题目:流感病毒NS1蛋白108、189双突变调控IFN-λ机制研究~~
邮箱(Email): fengye621@126.com;
DOI: 10.13242/j.cnki.bingduxuebao.004383
发布时间: 2023-09-05
出版时间: 2023-09-05
网络发布时间: 2023-09-05
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摘要:

先天免疫应答是机体防御的第一道防线,激活炎症通路清除病毒。流感病毒感染可诱导Ⅲ型干扰素(Type Ⅲ interferons, IFNs),即IFN-λ1、λ2和IFN-λ3表达,是宿主抵抗流感病毒的关键细胞因子。流感病毒感染时,病原体相关分子模式的病毒成分被宿主病原体识别受体识别,激活多个先天免疫细胞信号级联通路,最终诱导产生Ⅲ型干扰素以及其他各种促炎细胞因子和趋化分子。Ⅲ型干扰素通过诱导干扰素刺激基因(Interferon-stimulated genes, ISGs)表达抗病毒因子抑制病毒复制以及调控T细胞免疫等机制,发挥抗流感病毒作用。本文综述了Ⅲ型干扰素及其在流感病毒先天免疫机制中的最新进展。

Abstract:

The innate immune system serves as the first line of defense, including activation of inflammatory pathways which facilitate viral clearance. In the event of influenza virus infection, expression of type Ⅲ interferons(IFN-λ1, IFN-λ2 and IFN-λ3) is induced. These key cytokines play crucial roles in mediating the antiviral response against influenza virus. The viral pathogen-associated molecular pattern is recognized by pattern recognition receptors, triggering a series of innate immune signaling cascades that result in the expression of type Ⅲ interferons and other pro-inflammatory cytokines and chemokines. Type Ⅲ interferons counteract the influenza virus by inducing the expression of interferon-stimulated genes(ISGs) that induces antiviral factors and support T-cell immunity. In this review, we describe the latest advances pertaining to type Ⅲ interferons and explicate their roles in the mechanisms of innate immunity against influenza virus.

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基本信息:

DOI:10.13242/j.cnki.bingduxuebao.004383

中图分类号:R978.7

引用信息:

[1]赵璐,姜涛,冯烨.Ⅲ型干扰素抗流感病毒作用的研究进展[J].病毒学报,2023,39(05):1455-1462.DOI:10.13242/j.cnki.bingduxuebao.004383.

基金信息:

病原微生物生物安全国家重点实验室自主研究课题(项目号:SKLPBS2209),题目:流感病毒NS1蛋白108、189双突变调控IFN-λ机制研究~~

发布时间:

2023-09-05

出版时间:

2023-09-05

网络发布时间:

2023-09-05

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