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登革病毒(Dengue virus,DENV)是一种严重威胁我国南方地区公众健康的虫媒病毒,无特异性的治疗方法和疫苗。单纯的登革病毒结构蛋白疫苗不能诱导针对四种血清型DENV的均衡、持久的保护性免疫,可能需要非结构蛋白成分。DENV非结构蛋白1(Non-structural 1protein,NS1)在登革病毒致病和保护性机制中具有重要的作用,该蛋白诱导的免疫可能在防治登革疾病中具有重要的作用。本文就DENV NS1结构及功能的研究进展作一综述。
Abstract:Dengue virus(DENV)is a re-emerging disease transmitted by the Aedes mosquitoes and has become a major public health problem in southern China.Currently,no antiviral drug or effective vaccine exist to control this disease.The chimeric DENV structural protein vaccine cannot elicit balanced levels of protective immunity to each of the four viral serotypes;therefore,non-structural protein components may be required to construct an effective DENV vaccine.The Dengue virus non-structural 1(DENV NS1)protein plays a critical role in viral pathogenesis and protective immunity.Therefore,immunity to Dengue 1-4NS1 subtypes may be crucial for the prevention of severe disease.This review attempts to provide an overview about the structure and function of DENV NS1.
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基本信息:
DOI:10.13242/j.cnki.bingduxuebao.002583
中图分类号:R373.33
引用信息:
[1]陈月,任瑞文,刘建伟.登革病毒非结构蛋白1结构及功能研究进展[J].病毒学报,2014,30(06):683-688.DOI:10.13242/j.cnki.bingduxuebao.002583.
2014-12-02
2014-12-02
2014-12-02