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寨卡病毒(Zika virus,ZIKV)作为一种新出现的蚊媒病原体,与成人格林-巴利综合征(Guillain–Barré syndrome,GBS)、新生儿小头畸形以及神经系统缺陷等疾病有关。2016年世界卫生组织将寨卡疫情列为国际关注的公共卫生突发事件,近年来关于ZIKV病原学、流行病学、感染与致病、抗病毒免疫应答、疫苗与药物的研究越来越多,为有效防控该病提供了理论依据和具体实践。本文就ZIKV蛋白组成及相应功能、感染周期、ZIKV受体及ZIKV-宿主相互作用等的最新研究进展进行综述,旨在正确认识和深入理解ZIKV致病与机体抗病相关机制,为设计有效的预防或治疗疫苗或药物提供参考资料。
Abstract：Zika virus(ZIKV)is an emerging mosquito-borne pathogen,which is associated with Guillain –Barré syndrome in adults and microcephaly and other neurological defects in newborns. The world health organization listed ZIKV infection to be a public health emergency of international concern in 2016. In recent years,increasing numbers of studies have been conducted on the etiology,epidemiology,infection pathways and pathogenesis of the ZIKV,as well as the antiviral immune response,vaccine development and potential drugs. Such studies have provided a theoretical basis and practice guidelines for the effective prevention and control of ZIKV infection. Here,we detail the latest research progress on the protein structure and function,infection cycle,receptors of the ZIKV as well as ZIKV-host interactions. In this way,we provide reference material for the design of efficacious vaccines or drugs.
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基本信息:
DOI：10.13242/j.cnki.bingduxuebao.003735
中图分类号:R373.3
引用信息:
[1]任琴,杜寿文,吕孔鹏,等.寨卡病毒及其与宿主蛋白相互作用研究进展[J].病毒学报,2020,36(06):1201-1207.DOI:10.13242/j.cnki.bingduxuebao.003735.
基金信息:
国家自然科学基金(项目号:31702210),题目:不同种属的宿主限制因子IFITM3抗流感病毒共有模式研究; 兽医生物技术国家重点实验室开放课题(项目号:SKLVBF201914),题目:甲型流感病毒HA蛋白与IFITM3间的相互作用机制~~
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